Catecholaminergic polymorphic ventricular tachycardia is an ion channelopathy, caused by mutations in genes coding for calcium-handling proteins. It can coexist with left ventricular non-compaction. We aim to investigate the clinical and genetic characteristics of this co-phenotype.

Medical records of 24 patients diagnosed with catecholaminergic polymorphic ventricular tachycardia in two Chinese hospitals between September, 2005, and January, 2020, were retrospectively reviewed. We evaluated their clinical and genetic characteristics, including basic demographic data, electrocardiogram parameters, medications and survival during follow-up, and their gene mutations. We did structural analysis for a novel variant ryanodine receptor 2-E4005V.

The patients included 19 with catecholaminergic polymorphic ventricular tachycardia mono-phenotype and 5 catecholaminergic polymorphic ventricular tachycardia-left ventricular non-compaction overlap patients. The median age of onset symptoms was 9.0 (8.0,13.5) years. Most patients (91.7%) had cardiac symptoms, and 50% had a family history of syncope. Overlap patients had lower peak heart rate and threshold heart rate for ventricular tachycardia and ventricular premature beat during the exercise stress test (p < 0.05). Sudden cardiac death risk may be higher in overlap patients during follow-up. Gene sequencing revealed 1 novel ryanodine receptor 2 missense mutation E4005V and 1 mutation previously unreported in catecholaminergic polymorphic ventricular tachycardia, but no left ventricular non-compaction-causing mutations were observed. In-silico analysis showed the novel mutation E4005V broke down the interaction between two charged residues.

Catecholaminergic polymorphic ventricular tachycardia overlapping with left ventricular non-compaction may lead to ventricular premature beat/ventricular tachycardia during exercise stress test at lower threshold heart rate than catecholaminergic polymorphic ventricular tachycardia alone; it may also indicate a worse prognosis and requires strict follow-up. ryanodine receptor 2 mutations disrupted interactions between residues and may interfere the function of ryanodine receptor 2.

There is growing evidence that gray matter atrophy is constrained by normal brain network (or connectome) architecture in neuropsychiatric disorders. However, whether this finding holds true in individuals with depression remains unknown. In this study, we aimed to investigate the association between gray matter atrophy and normal connectome architecture at individual level in depression.

In this study, 297 patients with depression and 256 healthy controls (HCs) from two independent Chinese dataset were included: a discovery dataset (105 never-treated first-episode patients and matched 130 HCs) and a replication dataset (106 patients and matched 126 HCs). For each patient, individualized regional atrophy was assessed using normative model and brain regions whose structural connectome profiles in HCs most resembled the atrophy patterns were identified as putative epicenters using a backfoward stepwise regression analysis.

In general, the structural connectome architecture of the identified disease epicenters significantly explained 44% (±16%) variance of gray matter atrophy. While patients with depression demonstrated tremendous interindividual variations in the number and distribution of disease epicenters, several disease epicenters with higher participation coefficient than randomly selected regions, including the hippocampus, thalamus, and medial frontal gyrus were significantly shared by depression. Other brain regions with strong structural connections to the disease epicenters exhibited greater vulnerability. In addition, the association between connectome and gray matter atrophy uncovered two distinct subgroups with different ages of onset.

These results suggest that gray matter atrophy is constrained by structural brain connectome and elucidate the possible pathological progression in depression.

Autism patients often encounter challenges in social interaction and emotional expression. This research investigates the potential positive effects of utilizing a design psychology perspective in the creation of children’s products for individuals with autism.

A group of autistic patients were selected as the research subjects and divided into an experimental group and a control group. The experimental group used children’s products guided by design psychology theory for daily games and learning activities, to improve the communication and emotional expression abilities of patients with autism. The control group used traditional children’s products. The study collected autism scale scores and communication observation data as the main research indicators and used Epidata2.0 for data processing.

The autism scale scores of the experimental group of patients with autism significantly decreased. The experimental results showed that the autism scale score of the experimental group patients decreased from the initial 28.6 to 15.2, while the autism scale score of the control group patients decreased from the initial 29.1 to 24.7. The Epidata2.0 method was used to verify the statistically significant differences between the experimental group and the control group.

Designing children’s products through the lens of research and design psychology can yield positive outcomes for patients with autism. This approach contributes to the enhancement of their social communication and emotional expression capabilities, thereby fostering their overall development.

Any product design cannot do without color design, and color is also an important form of psychological treatment for anxiety disorders. This study is based on color, optimizing product design, intervening, and treating consumer anxiety disorders, and combining conventional medical methods to improve consumers’ sub-health status and generate positive social effects.

We performed a MEDLINE search focusing on the past 10 years. Keywords used were attachment, neurobiology, and psychotherapy. We included original studies and existing reviews looking at all types of formal psychotherapy used and focusing on human research. Exclusion criteria were non-psychotherapeutic interventions and attachment based on couples only.

The experimental results showed that the number of people who observed red light was greater than that of those who observed blue light, and the number of people who observed green and blue light was 21,25. The order of changing colors has little effect on the experimental results. The level of activity in brain regions varies with color, with darker red areas indicating more active brain activity, while darker blue areas indicating less active brain activity.

Red light makes the brain tense and excited, while blue light makes the brain calm and relaxed. Design products with colors, expressing emotions through color combinations on the screen. Faced with the psychological dilemma of anxiety, through the application of color in product design, color optimization is carried out to explore effective color application solutions that can be suitable for various psychological needs.

In the new era, college students are facing more and more job competition, leading to more and more college students suffering from generalized anxiety disorder. The reform of innovation and entrepreneurship training mode is regarded as a way that may help relieve the anxiety symptoms of college students because it can help their employment.

300 college students were randomly divided into an experimental group and a control group. The control group participated in the traditional entrepreneurship training course, and the experimental group participated in the innovative entrepreneurship training course. They received an 8-week training in innovation and entrepreneurship. This training included career planning guidance, entrepreneurial practice projects, and mental health guidance. The Generalized Anxiety Disorder 7 (GAD-7) was used to evaluate the status of students.

The results showed that the average score of the General anxiety symptom assessment scale of the experimental group decreased from 10.8 before the experiment to 6.2 after the training (P < 0.05). The average score of the control group decreased from 10.9 before the experiment to 9.8 after the training (P < 0.05). In the long-term follow-up, the anxiety symptoms of the experimental group remained at a low level, while the anxiety symptoms of the control group increased significantly.

It shows that the reform of innovation and entrepreneurship training mode has a positive effect on the improvement of generalized anxiety disorder of college students in the new era.

Social anxiety disorder (SAD) among adolescents is a significant mental health concern that can hinder their social and emotional development. This study explores the positive effects of a psychosocial therapy model based on the news media context for treating social anxiety disorder in adolescents.

A randomized controlled trial design was employed, involving 120 adolescents diagnosed with SAD. Participants were divided into two groups: the intervention group and the control group. The intervention group received the psychosocial therapy model based on the news media context, while the control group received standard treatment. The Stanford Acute Stress Response Questionnaire (SASRQ) and the 3-min Confusion Assessment Scale (3D-CAM) were utilized to assess anxiety levels and cognitive functioning, respectively. Data analysis was conducted using SPSS23.0 software.

The results indicated significant reductions in anxiety levels within the intervention group compared to the control group (P< 0.05). Furthermore, cognitive functioning, as assessed by the 3D-CAM, showed significant improvement in the intervention group (P< 0.05). Participants in the intervention group reported increased self-confidence, improved social skills, and decreased social anxiety symptoms.

The psychosocial therapy model based on the news media context demonstrated positive effects in the treatment of social anxiety disorder among adolescents. The findings suggest that incorporating news media scenarios into therapy can enhance the overall treatment outcomes, including anxiety reduction and cognitive improvement. This integrated approach has the potential to positively impact adolescents’ social functioning and emotional well-being. Further research is warranted to validate and expand upon these findings.

With the continuous development of globalization, the internationalization of tourism has become an important trend in today’s society. More and more people are choosing to travel abroad to experience the diversity of different countries and cultures. However, when most tourists travel, they will inevitably have anxiety due to a variety of factors such as worrying about the quality of the tour, whether the plane is delayed, whether the diet is customary, and so on.

This paper is to further understand and study the influence of cross-cultural tourism on tourists’ generalized anxiety disorder, and improve tourists’ travel experience and mental health. In this study, 50 tourists with generalized anxiety disorder were selected as experimental subjects. Among them, 25 tourists were in the experimental group who received cross-cultural tourism treatment, and 25 tourists were in the control group that received traditional psychological treatment. The treatment period was 3 months for both groups.

The results were measured using anxiety items from the Stanford Acute Stress Response Questionnaire (SASRQ). The higher the score, the more severe the anxiety. The experimental results showed that the anxiety symptoms of tourists in the experimental group were generally reduced, and their mental health was greatly improved, with a comprehensive evaluation score of 9 points, while some tourists in the control group had poor treatment effects, with a comprehensive score of 15 points.

Cross-cultural tourism in the context of internationalization has a positive therapeutic effect on tourists’ generalized anxiety disorder.

In the current mode of higher education, students’ attention in class is generally flawed, which seriously affects teaching order and efficiency, and brings many troubles to students’ learning and teachers’ teaching. The aim of this study is to optimize the impact of attention deficit on students’ development by combining a teaching model in universities based on cognitive psychology.

The study selected 2000 college students from three universities in a certain city as the experimental subjects. They were randomly divided into an experimental group and a control group based on the number of people. The experimental group adopted a teaching model combining cognitive psychology, while the control group adopted a traditional teaching model. The experimental duration was one semester. Conners Rating Scales was used to evaluate the attention deficit disorder of all students, and SPSS23.0 software was used to statistically analyze the results.

The research results indicate that the experimental group of students showed significant improvements in class attention, learning status, and satisfaction with efficient teaching, with a 25% increase in classroom learning efficiency.

The statistical research results indicate that the college teaching model combined with cognitive psychology has a significant effect on improving students’ attention deficit, providing new ideas for efficient classroom teaching models. It is recommended that universities strengthen the application of cognitive psychology in student teaching management.

Households in poverty often face psychological stress and anxiety disorders, which affect their poverty alleviation outcomes and quality of life. Emotion-Focused Therapy (EFT) is an effective psychological intervention that helps individuals regulate emotions and cope with stress. This study aims to investigate the impact of EFT on anxiety disorders and provide effective intervention methods and support.

100 impoverished households with anxiety disorders were selected as the experimental group for EFT and another 100 with the same situation as control group. The Beck Anxiety Inventory (BAI) was used to evaluate both groups, along with the application of EFT. Each treatment cycle consisted of 10 sessions, and three cycles constituted one treatment course. Depression scores were assessed for both groups at the end of each cycle until four treatment courses were completed.

After one treatment course, the average scores for the experimental and control groups were 52 and 53, respectively. After three treatment courses, the average scores were 43 and 52 for the experimental and control groups, respectively. After the intervention of EFT, the experimental group showed a significant reduction in anxiety levels, improved emotional regulation, and alleviation of psychological stress during the poverty alleviation process. There were no significant changes in anxiety levels for the control group.

EFT has a positive impact on anxiety disorders during the poverty alleviation process for rural households. These research findings provide a basis for effective intervention measures and support for rural households, enabling them to better cope with psychological distress and challenges during the poverty alleviation process.