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Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer’s disease, Alzheimer’s disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis
Sandeep R. Pagali, Rakesh Kumar, Allison M. LeMahieu, Michael R. Basso, Bradley F. Boeve, Paul E. Croarkin, Jennifer R. Geske, Leslie C. Hassett, John Huston III, Simon Kung, Brian N. Lundstrom, Ronald C. Petersen, Erik K. St. Louis, Kirk M. Welker, Gregory A. Worrell, Alvaro Pascual-Leone, Maria I. Lapid
Journal:

International Psychogeriatrics , First View

Published online by Cambridge University Press:

08 February 2024, pp. 1-49
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Objective:
We aim to analyze the efficacy and safety of TMS on cognition in mild cognitive impairment (MCI), Alzheimer’s disease (AD), AD-related dementias, and nondementia conditions with comorbid cognitive impairment.
Design:
Systematic review, Meta-Analysis
Setting:
We searched MEDLINE, Embase, Cochrane database, APA PsycINFO, Web of Science, and Scopus from January 1, 2000, to February 9, 2023.
Participants and interventions:
RCTs, open-label, and case series studies reporting cognitive outcomes following TMS intervention were included.
Measurement:
Cognitive and safety outcomes were measured. Cochrane Risk of Bias for RCTs and MINORS (Methodological Index for Non-Randomized Studies) criteria were used to evaluate study quality. This study was registered with PROSPERO (CRD42022326423).
Results:
The systematic review included 143 studies (n = 5,800 participants) worldwide, encompassing 94 RCTs, 43 open-label prospective, 3 open-label retrospective, and 3 case series. The meta-analysis included 25 RCTs in MCI and AD. Collectively, these studies provide evidence of improved global and specific cognitive measures with TMS across diagnostic groups. Only 2 studies (among 143) reported 4 adverse events of seizures: 3 were deemed TMS unrelated and another resolved with coil repositioning. Meta-analysis showed large effect sizes on global cognition (Mini-Mental State Examination (SMD = 0.80 [0.26, 1.33], p = 0.003), Montreal Cognitive Assessment (SMD = 0.85 [0.26, 1.44], p = 0.005), Alzheimer’s Disease Assessment Scale–Cognitive Subscale (SMD = −0.96 [−1.32, −0.60], p < 0.001)) in MCI and AD, although with significant heterogeneity.
Conclusion:
The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.

Interconnectedness among frailty, sleep, and cognition: recent findings and clinical implications
Alexandra M. V. Wennberg, Erik K. St. Louis
Journal:

International Psychogeriatrics / Volume 31 / Issue 6 / June 2019

Published online by Cambridge University Press:

10 July 2019, pp. 763-766
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Preface
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

Print publication:

14 June 2018, pp vii-viii
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Phenytoin
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

Print publication:

14 June 2018, pp 225-237
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Lorazepam
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

Print publication:

14 June 2018, pp 155-165
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Clobazam
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

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01 June 2018

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14 June 2018, pp 41-50
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Lamotrigine
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

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01 June 2018

Print publication:

14 June 2018, pp 129-143
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Tiagabine
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

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01 June 2018

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14 June 2018, pp 292-300
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Eslicarbazepine Acetate
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

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14 June 2018, pp 71-80
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Felbamate
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

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01 June 2018

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14 June 2018, pp 90-98
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Levetiracetam
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

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01 June 2018

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14 June 2018, pp 144-154
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Gabapentin
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

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01 June 2018

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14 June 2018, pp 109-119
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Fosphenytoin
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

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14 June 2018, pp 99-108
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Carbamazepine
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

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14 June 2018, pp 28-40
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Acetazolamide
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

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14 June 2018, pp 1-10
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Zonisamide
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

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14 June 2018, pp 339-350
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Abbreviations
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

Print publication:

14 June 2018, pp 351-351
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Paraldehyde
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

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14 June 2018, pp 196-203
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Brivaracetam
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

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01 June 2018

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14 June 2018, pp 19-27
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Sulthiame
Philip N. Patsalos, Erik K. St Louis
Book:

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

Published online:

01 June 2018

Print publication:

14 June 2018, pp 282-291
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Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer’s disease, Alzheimer’s disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis

Interconnectedness among frailty, sleep, and cognition: recent findings and clinical implications

Preface

Phenytoin

Lorazepam

Clobazam

Lamotrigine

Tiagabine

Eslicarbazepine Acetate

Felbamate

Levetiracetam

Gabapentin

Fosphenytoin

Carbamazepine

Acetazolamide

Zonisamide

Abbreviations

Paraldehyde

Brivaracetam

Sulthiame

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45 results