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This study aimed to investigate general factors associated with prognosis regardless of the type of treatment received, for adults with depression in primary care.
We searched Medline, Embase, PsycINFO and Cochrane Central (inception to 12/01/2020) for RCTs that included the most commonly used comprehensive measure of depressive and anxiety disorder symptoms and diagnoses, in primary care depression RCTs (the Revised Clinical Interview Schedule: CIS-R). Two-stage random-effects meta-analyses were conducted.
Twelve (n = 6024) of thirteen eligible studies (n = 6175) provided individual patient data. There was a 31% (95%CI: 25 to 37) difference in depressive symptoms at 3–4 months per standard deviation increase in baseline depressive symptoms. Four additional factors: the duration of anxiety; duration of depression; comorbid panic disorder; and a history of antidepressant treatment were also independently associated with poorer prognosis. There was evidence that the difference in prognosis when these factors were combined could be of clinical importance. Adding these variables improved the amount of variance explained in 3–4 month depressive symptoms from 16% using depressive symptom severity alone to 27%. Risk of bias (assessed with QUIPS) was low in all studies and quality (assessed with GRADE) was high. Sensitivity analyses did not alter our conclusions.
When adults seek treatment for depression clinicians should routinely assess for the duration of anxiety, duration of depression, comorbid panic disorder, and a history of antidepressant treatment alongside depressive symptom severity. This could provide clinicians and patients with useful and desired information to elucidate prognosis and aid the clinical management of depression.
Structural models of psychopathology consistently identify internalizing (INT) and externalizing (EXT) specific factors as well as a superordinate factor that captures their shared variance, the p factor. Questions remain, however, about the meaning of these data-driven dimensions and the interpretability and distinguishability of the larger nomological networks in which they are embedded.
The sample consisted of 10 645 youth aged 9–10 years participating in the multisite Adolescent Brain and Cognitive Development (ABCD) Study. p, INT, and EXT were modeled using the parent-rated Child Behavior Checklist (CBCL). Patterns of associations were examined with variables drawn from diverse domains including demographics, psychopathology, temperament, family history of substance use and psychopathology, school and family environment, and cognitive ability, using instruments based on youth-, parent-, and teacher-report, and behavioral task performance.
p exhibited a broad pattern of statistically significant associations with risk variables across all domains assessed, including temperament, neurocognition, and social adversity. The specific factors exhibited more domain-specific patterns of associations, with INT exhibiting greater fear/distress and EXT exhibiting greater impulsivity.
In this largest study of hierarchical models of psychopathology to date, we found that p, INT, and EXT exhibit well-differentiated nomological networks that are interpretable in terms of neurocognition, impulsivity, fear/distress, and social adversity. These networks were, in contrast, obscured when relying on the a priori Internalizing and Externalizing dimensions of the CBCL scales. Our findings add to the evidence for the validity of p, INT, and EXT as theoretically and empirically meaningful broad psychopathology liabilities.
Large material accumulations from single events found in the archaeological record are frequently defined as evidence of ritual. They are interpreted as generalized deposit categories that imply rather than infer human motivations. While useful in the initial collection of data, these categories can, over time, become interpretations in and of themselves. The emic motivations behind the formation process of ‘ritual deposits’ ought to be considered using a relational ontology as an approach to understanding how past populations interacted with non-human actors, such as structures and natural features on the landscape. The present study evaluates the assembly and possible function of a dense deposit of artifacts recovered from a Classic period sweat bath at Xultun, Guatemala. Analyses of the various artifact types and human remains in the deposit in relation to what is known of the social history of the sweat bath itself illustrate ontological relationships among offered materials as well as between the offering and the personified place in which it was recovered. We observe that with a better understanding of place, it is possible to evaluate the ritual logic in Classic Maya material negotiations.
The ACA shifted U.S. health policy from centering on principles of actuarial fairness toward social solidarity. Yet four legal fixtures of the health care system have prevented the achievement of social solidarity: federalism, fiscal pluralism, privatization, and individualism. Future reforms must confront these fixtures to realize social solidarity in health care, American-style.
If federal health reforms continue to rely on employer-sponsored health care coverage, ERISA preemption reform should be part of the next steps. State-level reform has acquired greater urgency, while the justifications for preempting that source of reform has eroded. This article recommends a statutory waiver for ERISA preemption as a feasible way to adapt to these circumstances. It offers proposed statutory text for reformers inclined to pursue ERISA reform as health reform.
Disparities exist in the health, livelihood, and opportunities for the 46-60 million people living in America’s rural communities. Rural communities across the United States need a new energy and focus concentrated around health and health care that allows for the designing capturing, and spreading of existing and new innovations. This paper aims to provide a framework for policy solutions to build a healthier rural America describing both the current state of rural health policy and the policies and practices in states that could be used as a national model for positive change.
My thanks to Maria Doerfler for organizing a session at the January 2020 meeting of the American Society of Church History on my book The Fathers Refounded: Protestant Liberalism, Roman Catholic Modernism, and the Teaching of Ancient Christianity in Early Twentieth-Century America, to the editors of Church History for suggesting that the (revised) papers from the session could find a home in print, and, especially, to the panelists for their insightful comments.
Dissemination and implementation (D&I) science is dedicated to studying how to effectively translate and apply research in real-world contexts. There has been increasing interest in health equity within the D&I field to ensure the equitable implementation of evidence-based programs/practices across a range of diverse populations and settings. At the same time, health equity researchers recognize the potential of D&I science to promote the more widespread dissemination, implementation, and sustainment of evidence-based interventions to address health inequities. The National Center for Accelerating Clinical and Translational Science Clinical and Translational Science Award (CTSA) Program has been a champion for community engagement and translational scholarship in its mission to improve individual and population health. The overall CTSA infrastructure and resources within and among CTSA hubs are well-equipped to facilitate a health equity focus to D&I across the phases of translational research. This paper proposes a framework that demonstrates the interaction and opportunities between health equity and D&I science and highlights how CTSAs can support and facilitate wider efforts in translational research with a focus on equitable D&I.
Obesity is an excess of adipose tissue (AT) and is linked with increased inflammation that enhances risk of type-2 diabetes and cardiovascular disease. The BIOCLAIMS study assessed the effect of obesity on AT fatty acid composition and gene expression, and the responses of these to chronic omega-3 FA supplementation.
Materials and methods:
AT biopsies were collected pre- and post-12 week supplementation with 1.1 g EPA + 0.8 g DHA/day or corn oil. The composition of FA in the total lipid extract of AT from 37 normal-weight and 44 obese subjects was assessed by gas chromatography, whole AT transcriptome from 10 normal-weight and 10 obese subjects was assessed by RNA-Sequencing, and selected gene expression in AT of 27 normal-weight and 38 obese subjects was assessed by qRT-PCR.
789 AT genes were differentially expressed (623 upregulated, 175 downregulated) in obesity compared to normal-weight (FC > 2, P < 0.05). Differentially expressed genes included EGFL6, MMP-7 and -9, 5-LOX, WNT3 and WNT10B, DACT2, CNR1, SLC27A2 and PLA2G7, and were associated with immune and inflammatory response, cell proliferation, activation and movement, Wnt signalling, remodelling and expansion, and lipid incorporation and degradation.
Chronic supplementation with EPA + DHA increased the concentration of AT EPA, DPA and DHA in normal-weight subjects (P < 0.01), and EPA in obese subjects (P = 0.006). EPA + DHA modulated the expression of 26 genes (14 upregulated, 12 downregulated) in normal-weight subjects and 7 genes (3 upregulated, 5 downregulated) in obese subjects (FC > 2, P < 0.05). Of note, EPA + DHA downregulated IGLV1-44, IGLV1-51, PROK2, and TREM1 in normal weight subjects (P < 0.05), and IGLV1-44, IGLV1-47, DACT2 and IDO1 obese subjects (P < 0.05). Genes of note upregulated by EPA + DHA included KCNH2, GCGR, SLC36A2 and FOXC2 in normal-weight subjects, and MAB21L1, LRRTM4, and COX-2, in obese subjects. Differentially expressed genes were associated with a decrease in complement activation and immunoglobulin secretion, negative regulation of cell proliferation, and positive regulation of remodelling, amino acid and glucose transport, and COX pathway metabolite synthesis.
These data indicate an altered AT transcription profile and gene expression in obesity suggesting enhanced immune and inflammatory response, tissue expansion and remodelling, and changes to lipid metabolism, as well as dysregulation in response to supplementary EPA + DHA at a gene expression level. EPA + DHA are able to modulate AT gene expression predominantly associated with reducing immune response, but obesity may involve resistance to the effects on tissue remodelling and nutrient transport.
This analysis focuses on the institutional talk of sea-kayak guides and their clients in order to understand how guides negotiate the interactional balance of giving orders to maintain a safe and timely excursion while facilitating a fun and recreational experience. Using a mixed-method analysis including Conversation Analysis, ethnography, and statistics, this study examines 576 instances of directives found in video recordings of twenty-five Alaskan kayaking ecotourism excursions and explores the practices guides use in their talk to maintain control of an excursion while not coming across as domineering. By systemically examining directives’ design, directives are found to reveal both their temporal urgency in addition to the precipitating events that necessitate them, such as client behaviors or environmental stimuli. This study's analysis contributes to our understanding of how interactants mitigate face-threatening actions and focuses attention on the interactional work that directives and their accounts achieve in an institutional setting currently underinvestigated (Directives, mixed-methods, Conversation Analysis, ethnography, ecotourism)*
In rainfed lowland rice-based systems, increasing labour scarcity due to off-farm employment is encouraging farmers to switch from transplanting to dry direct seeding (DDS). To assure stable productivity at a level comparable with or superior to transplanting, DDS management must ensure rice seedlings have access to nutrients in order to be competitive with weeds, which must also be suppressed. This paper examined farmer perceptions of DDS using a farmer survey, and used on-farm experiments to examine responses of rainfed lowland rice to integrated nutrient–weed management, based around mechanised DDS. In the survey, weeds were the biggest problem faced by farmers in using DDS (61%). In 90% of cases, farmers reported that weeds had increased under DDS, with most farmers (78%) controlling weeds by hand. All farmers said they would use DDS in the following season (100%), due to labour savings (47%), timeliness of operations, improved productivity, low investment or a combination of these (44%). In on-farm experiments, banding nutrients with the seed at sowing enhanced early dry matter of rice, while early weed dry matter was reduced. Early weed control using ducklings or hand weeding reduced weed competition and increased rice growth, with ducklings providing additional yield benefits over hand weeding. Early increases in seedling vigour of rice, and in weed suppression, carried through to greater dry matter and yield of rice at maturity. Integrated nutrient–weed management in mechanised DDS increased DDS yields, reduced DDS yield variability and contributed to sustainability of DDS rice systems.
Elizabeth Forster, Registered Nurse and Senior Lecturer in the Faculty of Health, Engineering and Sciences at the University of Southern Queensland.,
Loretta Scaini-Clarke, aediatric Intensive Care Nurse Educator, and has over 30 years’ experience as a critical care nurse
• Gain an understanding of normal assessment findings in the paediatric patient and those indicating deterioration
• Learn how to recognise a sick or deteriorating child using an appropriate framework
• Develop an understanding of how to respond to a sick or deteriorating child and provide appropriate respiratory and circulatory support
• Learn the elements of paediatric cardiopulmonary resuscitation • Consider the importance of supporting families and parental presence during paediatric resuscitation
As a nurse caring for paediatric patients, it is important for you to develop the ability to recognise and respond to a sick infant or child. The ability to do this is so important that a variety of projects have been undertaken, both internationally and throughout Australia, to ensure that nurses working with paediatric patients are able to recognise, respond promptly to and appropriately manage sick and deteriorating infants and children. Examples are the Between the Flags program in New South Wales, the Victorian Children's Tool for Observation and Response (VICTOR) and the Children's Early Warning Assessment Tool (CEWT) in Queensland. These programs aim to support the assessment skills of the clinician working with infants and children. Paediatric early warning tools help clinicians to recognise a deteriorating infant or child, and trigger an escalation in care to prevent further deterioration and achieve favourable outcomes. This chapter will provide you with a basic understanding and knowledge so that you will be able to recognise and respond to a sick and deteriorating child.
Clinical signs – a warning of deterioration – are often present in the paediatric patient as for as long as six to 12 hours before a catastrophic event. Failure to identify and treat these early warning signs can result in continued clinical deterioration until cardiopulmonary arrest. The poor outcomes associated with paediatric cardiopulmonary arrest emphasise the importance of being able to detect and respond to early signs of deterioration (McLellan & Connor, 2013).
The primary cause of paediatric cardiopulmonary arrest is respiratory in origin, and the second most common cause is circulatory failure.
Born and bred in Keighley, Carole Rawcliffe is a proud Yorkshirewoman and when minded to do so can express herself in broad Yorkshire. She studied History at Sheffield University and graduated with a first-class degree. This outstanding achievement would not cause much comment now. In 1967, however, she was one of only five History graduates there to have been awarded such a degree since 1952. She stayed at Sheffield to undertake research for her PhD under the supervision of Dr Robin Jeffs on the subject of the Stafford earls of Stafford and dukes of Buckingham, but left in 1971 to join the Royal Commission on Historical Manuscripts. The Historical Manuscripts Commission, as it is usually known, had been established in 1869 with the remit of surveying and reporting on those records, both public and private, that were not legally categorised as ‘Public Records’, and on the repositories where they were held. The Commission was then situated in Quality Court, off Chancery Lane, just 300 yards north of the Public Record Office, and when Carole arrived it was presided over as Secretary by Roger Ellis, a gentleman scholar with a distinguished war record and a delightful manner.
In many ways the HMC proved an excellent training ground, providing Carole with valuable opportunities to broaden her experience. The material in the Commission's published reports was exceptionally diverse both in content and in chronological range, and much of the work undertaken by its staff focused on the National Register of Archives, which had been established within the HMC in 1945 and contained many thousands of published and unpublished lists and catalogues of archival collections relating to all aspects of British history. These provided details of documents held in local authority, business and private archives across Great Britain and in repositories throughout the world. Relatively little medieval material was listed in the NRA catalogues, but the range and interest of the post-medieval material was very wide indeed, covering political, literary, scientific, diplomatic and ecclesiastical history as well as the records of commerce and industry and great family and estate collections.