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Donor insemination (DI) has undergone radical changes in the last 25 years, for example exclusive use of frozen semen, and increasing use of DI for single women. A summary of these is presented as are the potential challenges we still face. The latter include key questions such as what are the key methods for optimising treatment. Can we improve our success rates? If so, how can this be done? Moreover, the use of DI as a research tool, often ignored, is presented.
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