Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

31 results

Page 1 of 2

  • Predicting first-episode psychosis patients who will never relapse over 10 years
  • Christy LM Hui, William G Honer, Edwin HM Lee, WC Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, WS Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen
  • Journal: Psychological Medicine / Volume 49 / Issue 13 / October 2019
  • Published online by Cambridge University Press: 30 October 2018, pp. 2206-2214
  • Print publication: October 2019
  • View abstract
    Background

    Although relapse in psychosis is common, a small proportion of patients will not relapse in the long term. We examined the proportion and predictors of patients who never relapsed in the 10 years following complete resolution of positive symptoms from their first psychotic episode.

    Method

    Patients who previously enrolled in a 12-month randomized controlled trial on medication discontinuation and relapse following first-episode psychosis (FEP) were followed up after 10 years. Relapse of positive symptoms was operationalized as a change from a Clinical Global Impression scale positive score of <3 for at least 3 consecutive months to a score of ⩾3 (mild or more severe). Baseline predictors included basic demographics, premorbid functioning, symptoms, functioning, and neurocognitive functioning.

    Results

    Out of 178 first-episode patients, 37 (21%) never relapsed during the 10-year period. Univariate predictors (p ⩽ 0.1) of patients who never relapsed included a duration of untreated psychosis (DUP) ⩽30 days, diagnosed with non-schizophrenia spectrum disorders, having less severe negative symptoms, and performing better in logical memory immediate recall and verbal fluency tests. A multivariate logistic regression analysis further suggested that the absence of any relapsing episodes was significantly related to better short-term verbal memory, shorter DUP, and non-schizophrenia spectrum disorders.

    Conclusions

    Treatment delay and neurocognitive function are potentially modifiable predictors of good long-term prognosis in FEP. These predictors are informative as they can be incorporated into an optimum risk prediction model in the future, which would help with clinical decision making regarding maintenance treatment in FEP.

  • Studies of the loss of viability of bacterial aerosols*: III. Factors affecting death rates of certain non-pathogens
  • Ronald M. Ferry, William F. Brown, Edwin B. Damon
  • Journal: Epidemiology & Infection / Volume 56 / Issue 3 / September 1958
  • Published online by Cambridge University Press: 15 May 2009, pp. 389-403
    • Article
      • You have access
    • PDF
    • Export citation
  • View extract

    1. Additional quantitative studies of the survival of micro-organisms in aerosols are reported.

    2. Substitution of nitrogen for oxygen in the ambient medium decreases k′2, the rate of secondary loss of viability of M. candidus, Esch. coli and S. marcescens, by 30–50%.

    3. The rate of primary decay (k′1) of Esch. coli does not appear to be affected by a similar change of atmosphere.

    4. The rate of secondary decay, k′2, of M. candidus appears to increase two-to three-fold for 10°C. increments in temperature.

    5. Treatment of suspensions of Esch. coli with petroleum ether alone or containing lipid material increases k′1 in aerosols generated from such suspensions.

    6. Treatment of Myco. phlei with petroleum ether appears to lower resistance to subsequent sonic irradiation.

    These observations are consistent with the hypothesis that differences in the physical and chemical structure of micro-organisms are reflected in constants k′1, k′2 and b.

    We gratefully acknowledge the effective interest of two former assistants, T. Grant Maple and Eugene Mills, as well as the careful, effective, and conscientious work of our technical assistants, Ann Barr, Nora Galins, Cynthia Hartwig, Grace C. Leigh, Elizabeth Neidhardt, Paulette Slaney and Martha Szerslip, who have at different times helped secure the data presented here. Mrs Joseph J. Ecker deserves special thanks for care in the preparation of the manuscript.

  • Studies of the loss of viability of stored bacterial aerosols*. II. Death rates of several non-pathogenic organisms in relation to biological and structural characteristics
  • Ronald M. Ferry, William F. Brown, Edwin B. Damon
  • Journal: Epidemiology & Infection / Volume 56 / Issue 1 / March 1958
  • Published online by Cambridge University Press: 15 May 2009, pp. 125-150
    • Article
      • You have access
    • PDF
    • Export citation
  • View extract

    For several decades bacteriologists and epidemiologists have been interested in the survival of micro-organisms in the airborne state. Studies by many investigators, recently summarized by Wells (1955), have produced data concerning certain aspects of bacterial survival or death, but the information has not generally sufficed to permit quantitative analysis when a fluid environment was changed in the airborne state.

Page 1 of 2