Higher milk intake has been associated with a lower stroke risk, but not with risk of CHD. Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29 328 participants (4611 stroke; 9828 CHD) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD (eight European countries) and European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) case-cohort studies. rs4988235, a lactase persistence (LP) SNP which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777 024 participants (50 804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483 966 participants (61 612 cases) from CARDIoGRAM, UK Biobank, EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β = 13·7 g/d; 95 % CI 8·4, 19·1) and EPIC-NL (36·8 g/d; 95 % CI 20·0, 53·5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/d 1·05; 95 % CI 0·94, 1·16) or CHD (1·02; 95 % CI 0·96, 1·08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (OR 1·02; 95 % CI 0·99, 1·05) or CHD (OR 0·99; 95 % CI 0·95, 1·03). Current Mendelian randomisation analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk.

Blazar OJ287 exhibits large thermal flares at least twice every 12 years. The times of these flares have been predicted successfully using the model of a quasi-Keplerian eccentric black hole binary where the secondary impacts the accretion disk of the primary, creating the thermal flares. New measurements of the historical light curve have been combined with the observations of the 2015 November/December flare to identify the impact record since year 1886, and to constrain the orbit of the binary. The orbital solution shows that the binary period, now 12.062 years, is decreasing at the rate of 36 days per century. This corresponds to an energy loss to gravitational waves that is 6.5 ± 4 % less than the rate predicted by the standard quadrupolar gravitational wave (GW) emission. We show that the difference is due to higher order gravitational radiation reaction terms that include the dominant order tail contributions.

The blazar QSO B0218+357 is the first gravitationally lensed blazar detected in the very high energy (VHE, E > 100 GeV) gamma-ray spectral range (Ahnen et al. 2016). It is gravitationally lensed by the intervening galaxy B0218+357G (zl = 0.68466 ± 0.00004, Carilli et al. 1993), which splits the blazar emission into two components, spatially indistinguishable by gamma-ray instruments, but separated by a 10-12 days delay. In July 2014 a flare from QSO B0218+357 was observed by the Fermi-LAT (Large Area Telescope, Atwood et al. 2009, Ackermann et al. 2012), and followed-up by the MAGIC (Major Atmospheric Gamma Imaging Cherenkov) telescopes, a stereoscopic system of two 17m Imaging Atmospheric Cherenkov Telescopes located on La Palma, Canary Islands (Aleksić et al. 2016a, 2016b), during the expected time of arrival of the delayed component of the emission. MAGIC could not observe the leading image due to the Full Moon. The MAGIC and Fermi-LAT observations were accompanied by optical data from KVA telescope at La Palma, and X-ray observations by Swift-XRT (Fig. 1 left). Variability in gamma-rays was of the order of one day, while no variability correlated with gamma-rays was observed at lower energies. The flux ratio of the leading to trailing image in HE gamma-rays was larger than in the flare of QSO B0218+357 observed by Fermi-LAT in 2012 (Cheung et al. 2014). Changes in the observed flux ratio can be caused by gravitational microlensing on individual stars in the host galaxy (Neronov et al. 2015), or by other compact objects like for ex. clumps in giant molecular clouds (Sitarek & Bednarek 2016).

We explore the connection between the black hole mass and its relativistic jet for a sample of radio-loud AGN (z < 1), in which the relativistic jet parameters are well estimated by means of long term monitoring with the 14m Metsähovi millimeter wave telescope and the Very Long Base-line Array (VLBA). NIR host galaxy images taken with the NOTCam on the Nordic Optical Telescope (NOT) and retrieved from the 2MASS all-sky survey allowed us to perform a detailed surface brightness decomposition of the host galaxies in our sample and to estimate reliable black hole masses via their bulge luminosities. We present early results on the correlations between black hole mass and the relativistic jet parameters. Our preliminary results suggest that the more massive the black hole is, the faster and the more luminous jet it produces.

A widely accepted model for BL Lac objects is that they are radio galaxies with a relativistic jet pointing almost directly towards us. But we need a clear trigger mechanism for these jets. One possibility is the close interaction between the BL Lac host and the closeby galaxies (e.g. Heckman et al. 1986). This interaction has been seen many times in the case of quasars (Hutchings et al. 1989) but not so much is known about the close surroundings of the BL Lac objects although there has been some pioneer work like Stickel et al. (1993). The problem has usually been that the images are not deep enough and that the seeing has not been so good. To clarify the situation we have started an observing program to get very deep images in the sub-arcsecond seeing conditions from the whole 1 Jy sample (Stickel et al. 1991) of BL Lac objects. The aims of this study are: 1. to search for very close companions to the BL Lacs, 2. to study the large scale galaxy clustering around the BL Lacs and 3. to study the BL Lac hosts themselves.

Blazar OJ 287 is one of the best observed extragalactic objects. It's historical light curve goes back to 1890′s. Based on the historical behaviour Sillanpää et al. (1988) showed that OJ 287 displays large periodic outbursts, with a period of 11.7 years. We have monitored OJ 287 intensively for two years, during the OJ-94 project. This project was created for monitoring OJ 287 during its predicted new outburst in 1994. In the data archive we have over 7000 observations on OJ 287, in the radio, infrared and optical bands. This data archive contains the best ever obtained light curves for any extragalactic object. The optical light curve shows continuous variability down to time scales of tens of minutes. The variability observed in OJ 287 can be broken down to (at least) four different categories: