In this chapter, we examine how creativity, intelligence, and wisdom are related in theoretical frameworks and empirical studies. First, definitions of the three constructs are discussed. Although all of them are complex and multifaceted, the relationship between creativity and intelligence has been extensively studied based on their working definitions and models. However, wisdom research remains sparse, and there is a gap between people’s common beliefs and explicit theories of how wisdom is related to intelligence and creativity. Regardless, some common elements of wisdom have been distilled. These include self-awareness, knowledge, and strategies to cope with uncertainty, which can lead to contributions to social goodness. Second, several empirical studies are reviewed. They show some relationships among the three constructs, but the results have been inconsistent. Third, the WICS model, as a cognitive framework, is used to understand the relationships among the three constructs. The model integrated intelligence, creativity, and wisdom, and has also been tested in some fields. Finally, we argue that wisdom, as a distinguishable component of ability, can help determine whether our intelligence and creativity will be harnessed toward benevolence or malevolence.