To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The growth cycles and oncogenic properties of the murine and human retroviruses are inextricably linked to the immune system. Those viruses that cause leukaemias, lymphomas or immunodeficiencies do so by infecting and often activating immune cells. Conversely, those retroviruses that induce solid tumours must evolve ways to aid the host cell in evading the cellular immune system. One major molecular mechanism by which these retroviruses can either activate or evade the immune system is by control of MHC class I antigen expression in the cells they infect. An effect of murine retrovirus infection on MHC antigen expression was first suspected in the late 1970s, when it was observed that thymocytes obtained from animals several weeks after infection with leukaemia viruses appeared to express higher levels of MHC class I antigens than thymic cells from control animals. Conversely, down-regulation of MHC expression on solid tumours induced by oncogene-containing (sarcoma) retroviruses had also been observed. Because of the experimental constraints of these in vivo systems, however, proof of a causal relationship between retrovirus infection and MHC regulation was lacking. More recent studies have demonstrated a direct action of retroviruses on MHC gene regulation and have begun to elucidate the ways in which these compact viruses, with only 6000–10 000 bases of coding sequence, regulate the histocompatibility antigen expression of their host cells.
Murine leukaemia virusesy
The murine retroviruses can be broadly divided into two classes: the leukaemia viruses and the sarcoma viruses.
Email your librarian or administrator to recommend adding this to your organisation's collection.