To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Debra A. Hoppensteadt, Ph.D., Professor of Pathology and Pharmacology, Loyola University, Chicago Maywood, Illinois, USA,
Jawed Fareed, Ph.D., Professor of Pathology and Pharmacology, Loyola University, Chicago, Maywood, Illinois, USA,
Harry L. Messmore, M.D., Professor Emeritus Department of Medicine, Loyola University, Chicago, Maywood, Illinois, USA,
Omer Iqbal, M.D., Research Assistant Professor Department of Pathology, Loyola University, Chicago, Maywood, Illinois, USA,
William Wehrmacher, M.D., Professor Emeritus Department of Physiology, Loyola Univeristy, Chicago, Maywood, Illinois, USA,
Rodger L. Bick, M.D., Ph.D., Clinical Professor of Medicine and Pathology, University of Texas Southwestern Medical Center
The pathophysiology of the thrombotic process is multicomponent and involves blood, vascular system, humoral mediators and target sites. Furthermore, the intiating event and the site of thrombogenesis play a key role in the overall pathogenesis. The process of thrombogenesis is depicted in Figure 11.1. Initially, vascular injury results in the localized alterations of the vessels, generation of tissue factor, and subsequent activation of platelets. Activated cells mediate several direct or signal transduction induced processes resulting in the activation of platelets. Cellular activation also results in the release of various mediators which amplify vascular spasm and the coagulation process. Adhesion molecules, cytokines, oxidative stress and flow conditions signficantly contribute to the ischemic and occlusive outcome. Drugs that target various sites of the activation process have been developed to control thrombotic events. Because of the coupled pathophysiology, a drug that targets a single site may not be able to produce the desired therapeutic effects. Furthermore, many of these mediators produce localized actions at cellular and subcellular levels. Feedback amplification processes also play an important role in the pathology of these disorders and interruption of these pathways can be a therapeutic goal. This understanding has led to the concept of polytherapy in the management of thrombotic disorders.
Pregnancy and thrombosis
Pregnancy is associated with a hypercoagulable state that can lead to thrombosis and thromboembolism. The risk of venous thromboembolism (VTE) in pregnancy is approximately six times higher than in non-pregnant women.
Email your librarian or administrator to recommend adding this to your organisation's collection.