This article argues that the European Central Bank (ECB), supported by the Court of Justice of the European Union (CJEU), can be perceived to have functionally softened the no sovereign lender of last resort (LOLR) rule originally implied by Articles 123 and 125 of the Treaty on the Functioning of the European Union (TFEU) towards a rule-with-exceptions and, increasingly, towards a presumption: The ECB will act as sovereign LOLR to a constituent Member unless and until that Member is insolvent or unwilling to cooperate with measures designed to restore market confidence. This functional moderation of a rule, from an ex ante specification of an outcome towards the exercise of greater choice at the point of application, carries with it contentious normative questions. To motivate discussion thereof beyond a largely ahistorical, non-indexical, rules versus discretion debate, the rules of the currency union are located within the genealogy of international exchange rate regimes. The “convertibility” rule of the gold standard and the “parity” rule of the Bretton Woods system are contrasted with their Eurozone equivalent. A consequentialist standpoint is sketched out from which the interventions of the ECB, in light of their available alternatives, appear broadly consistent with welfarist cost-benefit analysis and less normatively worrisome than by reference to evaluative criteria that emphasize a narrowly rule-bound conception of the rule of law.

Sports participation, physical activity, and friendship quality are theorized to have protective effects on the developmental emergence of substance use and self-harm behavior in adolescence, but existing research has been mixed. This ambiguity could reflect, in part, the potential for confounding of observed associations by genetic and environmental factors, which previous research has been unable to rigorously rule out. We used data from the prospective, population-based Child and Adolescent Twin Study in Sweden (n = 18,234 born 1994–2001) and applied a co-twin control design to account for potential genetic and environmental confounding of sports participation, physical activity, and friendship quality (assessed at age 15) as presumed protective factors for adolescent substance use and self-harm behavior (assessed at age 18). While confidence intervals widened to include the null in numerous co-twin control analyses adjusting for childhood psychopathology, parent-reported sports participation and twin-reported positive friendship quality were associated with increased odds of alcohol problems and nicotine use. However, parent-reported sports participation, twin-reported physical activity, and twin-reported friendship quality were associated with decreased odds of self-harm behavior. The findings provide a more nuanced understanding of the risks and benefits of putative protective factors for risky behaviors that emerge during adolescence.

Authority of the European Central Bank (the Bank) over its operational norms in the eyes of market actors – Exogenous and endogenous authority and legitimacy – The reconciliation by the Bank and the Court of Justice of the EU (the Court) of the pre-existing norm and political-economic reality with Article 123 TFEU – Sovereign lender of last resort – Eurozone Crisis – Outright Monetary Transactions (OMT) – Public Sector Purchase Programme (PSPP) – Pandemic Emergency Purchase Programme (PEPP)

Horseweed and giant ragweed are competitive, annual weeds that can negatively impact crop yield. Biotypes of glyphosate-resistant (GR) giant ragweed and horseweed were first reported in 2008 and 2010 in Ontario, respectively. GR horseweed has spread throughout the southern portion of the province. The presence of GR biotypes poses new challenges for soybean producers in Canada and the United States. Halauxifen-methyl is a recently registered selective herbicide against broadleaf weeds for preplant use in corn and soybean. There is limited literature on the efficacy of halauxifen-methyl on GR horseweed and giant ragweed when combined with currently registered products in Canada. The purpose of this study was to determine the effectiveness of halauxifen-methyl applied alone and tank-mixed to control GR giant ragweed and GR horseweed in glyphosate and dicamba-resistant (GDR) soybean in southwestern Ontario. Six field experiments were conducted separately for each weed species over 2018 and 2019. Halauxifen-methyl applied alone offered 72% control of GR horseweed at 8 wk after application (WAA). Control was improved to >91% when halauxifen-methyl applied in combination with metribuzin, saflufenacil, chlorimuron-ethyl + metribuzin, and saflufenacil + metribuzin. At 8 WAA, halauxifen-methyl provided 11% control of GR giant ragweed, and 76% to 88% control when glyphosate/2,4-D choline, glyphosate/dicamba, glyphosate/2,4-D choline + halauxifen-methyl, and glyphosate/dicamba + halauxifen-methyl were used. We conclude that halauxifen-methyl applied preplant in a tank-mixture can provide effective control of GR giant ragweed and horseweed in GDR soybean.

Preplant (PP) herbicide applications are an important tool within an integrated weed management system, specifically in no-till production. An understanding of crop tolerance regarding PP applications is important for effectively integrating a new herbicide into no-till cropping systems. Twelve field trials (six in corn and six in soybean) were conducted over a 2-yr period (2018 and 2019) near Exeter and Ridgetown, ON. The purpose of these studies was to evaluate the tolerance of soybean and corn to halauxifen-methyl applied PP, PRE, or POST at the registered rate (5 g a.i. ha−1) and twice the registered rate (10 g a.i. ha−1), hereafter referred to as the 1× and 2× rate, respectively. All trials were kept weed-free throughout the growing season to remove the confounding effect of weed interference. Halauxifen-methyl applied 14 d preplant (DPP), 7 DPP, 1 DPP, and 5 d after seeding (DAS) at the 1× and 2× rates caused ≤10% visible soybean injury. In contrast, halauxifen-methyl applied POST (cotyledon–unifoliate stage, VE-VC) caused 67% to 87% visible soybean injury, a 50% to 53% reduction in height, 65% to 81% decrease in population, 56% to 67% lower biomass, and 53% to 63% decline in yield. Halauxifen-methyl applied 10 DPP, 5 DPP, 1 DPP, 5 DAS, and POST (spike–one leaf stage, VE-V1) at the 1× and 2× rate caused ≤3% visible corn injury and caused no effect on corn height or biomass. Halauxifen-methyl applied at VE-V1 at the 2× rate reduced corn yield 10%. Based on these studies, the current application restriction of 7 DPP in soybean and 5 DPP in corn is conservative and could be expanded. Expanding the application window of halauxifen-methyl would increase the utility of this herbicide for producers.

Horseweed is a competitive summer or winter annual weed that produces up to 230,000 small seeds per plant that are capable of traveling more than 500 km via wind. Giant ragweed is a tall, highly competitive summer annual weed. Glyphosate-resistant (GR) horseweed and GR giant ragweed pose significant challenges for producers in the United States and Ontario, Canada. It is thought that an integrated weed management (IWM) system involving herbicide rotation is required to control GR biotypes. Halauxifen-methyl is a new selective broadleaf POST herbicide registered for use in cereal crops; there is limited information on its efficacy on horseweed and giant ragweed. The purpose of this research was to determine the efficacy of halauxifen-methyl applied POST, alone and in a tank mix, for the control of GR horseweed and GR giant ragweed in wheat across southwestern Ontario. For each weed species, an efficacy study consisting of six field experiments was conducted over a 2-yr period (2018, 2019). At 8 wk after application (WAA), halauxifen-methyl, fluroxypyr/halauxifen-methyl, fluroxypyr/halauxifen-methyl + MCPA EHE, fluroxypyr + MCPA ester, 2,4-D ester, clopyralid, and pyrasulfotole/bromoxynil + ammonium sulfate controlled GR horseweed >95%. Fluroxypyr and MCPA provided only 86% and 37% control of GR horseweed, respectively. At 8 WAA, fluroxypyr, fluroxypyr/halauxifen-methyl, fluroxypyr/halauxifen-methyl + MCPA EHE, fluroxypyr + MCPA ester, fluroxypyr/halauxifen-methyl + MCPA EHE + pyroxsulam, 2,4-D ester, clopyralid, and thifensulfuron/tribenuron + fluroxypyr + MCPA ester controlled GR giant ragweed 87%, 88%, 90%, 94%, 96%, 96%, 98%, and 93%, respectively. Halauxifen-methyl and pyroxsulam provided only 45% and 28% control of GR giant ragweed, respectively. Halauxifen-methyl applied alone POST in the spring controlled GR horseweed but not GR giant ragweed in winter wheat.

Objective: Post-stroke cognitive impairment is common, but mechanisms and risk factors are poorly understood. Frailty may be an important risk factor for cognitive impairment after stroke. We investigated the association between pre-stroke frailty and acute post-stoke cognition. Methods: We studied consecutively admitted acute stroke patients in a single urban teaching hospital during three recruitment waves between May 2016 and December 2017. Cognition was assessed using the Mini-Montreal Cognitive Assessment (min=0; max=12). A Frailty Index was used to generate frailty scores for each patient (min=0; max=100). Clinical and demographic information were collected, including pre-stroke cognition, delirium, and stroke-severity. We conducted univariate and multiple-linear regression analyses with covariates forced in (covariates included were: age, sex, stroke severity, stroke-type, pre-stroke cognitive impairment, delirium, previous stroke/transient ischemic attack) to investigate the association between pre-stroke frailty and post-stroke cognition. Results: Complete data were available for 154 stroke patients. Mean age was 68 years (SD=11; range=32–97); 93 (60%) were male. Median mini-Montreal Cognitive Assessment score was 8 (IQR=4–12). Mean Frailty Index score was 18 (SD=11). Pre-stroke cognitive impairment was apparent in 13/154 (8%) patients. Pre-stroke frailty was significantly associated with lower post-stroke cognition (Standardized-Beta=−0.40; p<0.001) and this association was independent of covariates (Unstandardized-Beta=−0.05; p=0.005). Additional significant variables in the multiple regression model were age (Unstandardized-Beta=−0.05; p=0.002), delirium (Unstandardized-Beta=−2.81; p<0.001), pre-stroke cognitive impairment (Unstandardized-Beta=−2.28; p=0.001), and stroke-severity (Unstandardized-Beta=−0.20; p<0.001). Conclusions: Pre-stroke frailty may be a moderator of post-stroke cognition, independent of other well-established post-stroke cognitive impairment risk factors. (JINS, 2019, 25, 501–506)

We describe the motivation and design details of the ‘Phase II’ upgrade of the Murchison Widefield Array radio telescope. The expansion doubles to 256 the number of antenna tiles deployed in the array. The new antenna tiles enhance the capabilities of the Murchison Widefield Array in several key science areas. Seventy-two of the new tiles are deployed in a regular configuration near the existing array core. These new tiles enhance the surface brightness sensitivity of the array and will improve the ability of the Murchison Widefield Array to estimate the slope of the Epoch of Reionisation power spectrum by a factor of ∼3.5. The remaining 56 tiles are deployed on long baselines, doubling the maximum baseline of the array and improving the array u, v coverage. The improved imaging capabilities will provide an order of magnitude improvement in the noise floor of Murchison Widefield Array continuum images. The upgrade retains all of the features that have underpinned the Murchison Widefield Array’s success (large field of view, snapshot image quality, and pointing agility) and boosts the scientific potential with enhanced imaging capabilities and by enabling new calibration strategies.

Many perennial bioenergy grasses have the potential to escape cultivation and invade natural areas. We quantify dispersal, a key component in invasion, for two bioenergy candidates:Miscanthus sinensis and M. × giganteus. For each species, approximately 1 × 106 caryopses dispersed anemochorously from a point source into traps placed in annuli near the source (0.5 to 5 m; 1.6 to 16.4 ft) and in arcs (10 to 400 m) in the prevailing wind direction. For both species, most caryopses (95% for M. sinensis and 77% for M. × giganteus) were captured within 50 m of the source, but a small percentage (0.2 to 3%) were captured at 300 m and 400 m. Using a maximum-likelihood approach, we evaluated the degree of support in our empirical dispersal data for competing functions to describe seed-dispersal kernels. Fat-tailed functions (lognormal, Weibull, and gamma (Γ)) fit dispersal patterns best for both species overall, but because M. sinensis dispersal distances were significantly affected by wind speed, curves were also fit separately for dispersal distances in low, moderate, and high wind events. Wind speeds shifted the M. sinensis dispersal curve from a thin-tailed exponential function at low speeds to fat-tailed lognormal functions at moderate and high wind speeds. M. sinensis caryopses traveled farther in higher wind speeds (low, 30 m; moderate, 150 m; high, 400 m). Our results demonstrate the ability of Miscanthus caryopses to travel long distances and raise important implications for potential escape and invasion of fertile Miscanthus varieties from bioenergy cultivation.

The Asian grass Miscanthus sinensis (Poaceae) is being considered for use as a bioenergy crop in the U.S. Corn Belt. Originally introduced to the United States for ornamental plantings, it escaped, forming invasive populations. The concern is that naturalized M. sinensis populations have evolved shade tolerance. We tested the hypothesis that seedlings from within the invasive U.S. range of M. sinensis would display traits associated with shade tolerance, namely increased area for light capture and phenotypic plasticity, compared with seedlings from the native Japanese populations. In a common garden experiment, seedlings of 80 half-sib maternal lines were grown from the native range (Japan) and 60 half-sib maternal lines from the invasive range (U.S.) under four light levels. Seedling leaf area, leaf size, growth, and biomass allocation were measured on the resulting seedlings after 12 wk. Seedlings from both regions responded strongly to the light gradient. High light conditions resulted in seedlings with greater leaf area, larger leaves, and a shift to greater belowground biomass investment, compared with shaded seedlings. Japanese seedlings produced more biomass and total leaf area than U.S. seedlings across all light levels. Generally, U.S. and Japanese seedlings allocated a similar amount of biomass to foliage and equal leaf area per leaf mass. Subtle differences in light response by region were observed for total leaf area, mass, growth, and leaf size. U.S. seedlings had slightly higher plasticity for total mass and leaf area but lower plasticity for measures of biomass allocation and leaf traits compared with Japanese seedlings. Our results do not provide general support for the hypothesis of increased M. sinensis shade tolerance within its introduced U.S. range compared with native Japanese populations.

The world’s largest outbreak of Ebola virus disease began in West Africa in 2014. Although few cases were identified in the United States, the possibility of imported cases led US public health systems and health care facilities to focus on preparing the health care system to quickly and safely identify and respond to emerging infectious diseases. In New York City, early, coordinated planning among city and state agencies and the health care delivery system led to a successful response to a single case diagnosed in a returned health care worker. In this article we describe public health and health care system preparedness efforts in New York City to respond to Ebola and conclude that coordinated public health emergency response relies on joint planning and sustained resources for public health emergency response, epidemiology and laboratory capacity, and health care emergency management. (Disaster Med Public Health Preparedness. 2017;11:370–374).