This paper provides a detailed overview of how the COVID-19 pandemic has affected the income of charitable organisations – an under-researched theme within social policy, which thus far has largely focused on the impact of the pandemic on individuals’ and households’ wellbeing. It analyses a unique longitudinal dataset that follows through time c.90,000 charities in England and Wales. The results, for the first time, illustrate the scale of the pandemic’s financial impact on the charitable sector: the median charity experienced a 13% real decline in annual income, while a charity at the 25th percentile of the annual relative growth distribution experienced an income decline of 43%. Importantly these annual declines are much more sizeable than those associated with the Great Recession and subsequent period of public spending austerity. Smaller charities, particularly those with an income under £100k, have been most significantly affected. The declines have been pervasive, extending across most fields of charitable activity, though certain charitable fields have seen particularly acute declines. While there has rightly been considerable emphasis on the important role of voluntary action in responding to the pandemic, this new empirical evidence helps to communicate the extent of the recent challenges faced by the charitable sector.

Patients with single-ventricle CHD undergo a series of palliative surgeries that culminate in the Fontan procedure. While the Fontan procedure allows most patients to survive to adulthood, the Fontan circulation can eventually lead to multiple cardiac complications and multi-organ dysfunction. Care for adolescents and adults with a Fontan circulation has begun to transition from a primarily cardiac-focused model to care models, which are designed to monitor multiple organ systems, and using clues from this screening, identify patients who are at risk for adverse outcomes. The complexity of care required for these patients led our centre to develop a multidisciplinary Fontan Management Programme with the primary goals of earlier detection and treatment of complications through the development of a cohesive network of diverse medical subspecialists with Fontan expertise.

A nationwide survey indicated that screening for asymptomatic carriers of C. difficile is an uncommon practice in US healthcare settings. Better understanding of the role of asymptomatic carriage in C. difficile transmission, and of the measures available to reduce that risk, are needed to inform best practices regarding the management of carriers.

Objectives: Studies of neurocognitively elite older adults, termed SuperAgers, have identified clinical predictors and neurobiological indicators of resilience against age-related neurocognitive decline. Despite rising rates of older persons living with HIV (PLWH), SuperAging (SA) in PLWH remains undefined. We aimed to establish neuropsychological criteria for SA in PLWH and examined clinically relevant correlates of SA. Methods: 734 PLWH and 123 HIV-uninfected participants between 50 and 64 years of age underwent neuropsychological and neuromedical evaluations. SA was defined as demographically corrected (i.e., sex, race/ethnicity, education) global neurocognitive performance within normal range for 25-year-olds. Remaining participants were labeled cognitively normal (CN) or impaired (CI) based on actual age. Chi-square and analysis of variance tests examined HIV group differences on neurocognitive status and demographics. Within PLWH, neurocognitive status differences were tested on HIV disease characteristics, medical comorbidities, and everyday functioning. Multinomial logistic regression explored independent predictors of neurocognitive status. Results: Neurocognitive status rates and demographic characteristics differed between PLWH (SA=17%; CN=38%; CI=45%) and HIV-uninfected participants (SA=35%; CN=55%; CI=11%). In PLWH, neurocognitive groups were comparable on demographic and HIV disease characteristics. Younger age, higher verbal IQ, absence of diabetes, fewer depressive symptoms, and lifetime cannabis use disorder increased likelihood of SA. SA reported increased independence in everyday functioning, employment, and health-related quality of life than non-SA. Conclusions: Despite combined neurological risk of aging and HIV, youthful neurocognitive performance is possible for older PLWH. SA relates to improved real-world functioning and may be better explained by cognitive reserve and maintenance of cardiometabolic and mental health than HIV disease severity. Future research investigating biomarker and lifestyle (e.g., physical activity) correlates of SA may help identify modifiable neuroprotective factors against HIV-related neurobiological aging. (JINS, 2019, 25, 507–519)

Methyl cellulose based coatings applied to food before deep-fat frying can reduce the amount of oil absorbed by the food during cooking as measured by bulk analysis techniques. However, information about the distribution of oil in the food, and how that is impacted by the coatings is lacking. A method is presented using osmium tetroxide to stain the oil and light microscopy to visualize its distribution. The method was applied to French fries and showed that the extent of oil ingress was reduced when a methyl cellulose coating was used.

Objectives: Human immunodeficiency virus (HIV) disproportionately affects Hispanics/Latinos in the United States, yet little is known about neurocognitive impairment (NCI) in this group. We compared the rates of NCI in large well-characterized samples of HIV-infected (HIV+) Latinos and (non-Latino) Whites, and examined HIV-associated NCI among subgroups of Latinos. Methods: Participants included English-speaking HIV+ adults assessed at six U.S. medical centers (194 Latinos, 600 Whites). For overall group, age: M=42.65 years, SD=8.93; 86% male; education: M=13.17, SD=2.73; 54% had acquired immunodeficiency syndrome. NCI was assessed with a comprehensive test battery with normative corrections for age, education and gender. Covariates examined included HIV-disease characteristics, comorbidities, and genetic ancestry. Results: Compared with Whites, Latinos had higher rates of global NCI (42% vs. 54%), and domain NCI in executive function, learning, recall, working memory, and processing speed. Latinos also fared worse than Whites on current and historical HIV-disease characteristics, and nadir CD4 partially mediated ethnic differences in NCI. Yet, Latinos continued to have more global NCI [odds ratio (OR)=1.59; 95% confidence interval (CI)=1.13–2.23; p<.01] after adjusting for significant covariates. Higher rates of global NCI were observed with Puerto Rican (n=60; 71%) versus Mexican (n=79, 44%) origin/descent; this disparity persisted in models adjusting for significant covariates (OR=2.40; CI=1.11–5.29; p=.03). Conclusions: HIV+ Latinos, especially of Puerto Rican (vs. Mexican) origin/descent had increased rates of NCI compared with Whites. Differences in rates of NCI were not completely explained by worse HIV-disease characteristics, neurocognitive comorbidities, or genetic ancestry. Future studies should explore culturally relevant psychosocial, biomedical, and genetic factors that might explain these disparities and inform the development of targeted interventions. (JINS, 2018, 24, 163–175)

Motorcycle helmet laws are perceived to infringe upon individual rights even though they reduce mortality and health care costs. We describe proposed helmet legislation that protects individual rights and provides incentives for helmet use through a differential motorcycle registration fee that requires higher fees for those who wish to ride without a helmet.

Field experiments were conducted to evaluate the potential of hyperspectral reflectance data collected with a hand-held spectroradiometer to discriminate soybean intermixed with pitted morningglory and weed-free soybean in conventional till and no-till plots containing rye, hairy vetch, or no cover crop residue. Pitted morningglory was in the cotyledon to six-leaf growth stage. Seven 50-nm spectral bands (one ultraviolet, two visible, four near-infrared) derived from each hyperspectral reflectance measurement were used as discrimination variables. Pitted morningglory plant size had more influence on discriminant capabilities than tillage or cover crop residue systems. Across all tillage and residue systems, discrimination accuracy was 71 to 95%, depending on the size of pitted morningglory plants at the time of data acquisition. The versatility of the seven 50-nm bands was tested by using a discriminant model developed for one experiment location to test discriminant capabilities for the other experiment, with discrimination accuracy across all tillage and residue systems of 55 to 73%, depending on pitted morningglory plant size.

Field experiments were conducted in 1999 at Stoneville, MS, to determine the potential of multispectral imagery for late-season discrimination of weed-infested and weed-free soybean. Plant canopy composition for soybean and weeds was estimated after soybean or weed canopy closure. Weed canopy estimates ranged from 30 to 36% for all weed-infested soybean plots, and weeds present were browntop millet, barnyardgrass, and large crabgrass. In each experiment, data were collected for the green, red, and near-infrared (NIR) spectrums four times after canopy closure. The red and NIR bands were used to develop a normalized difference vegetation index (NDVI) for each plot, and all spectral bands and NDVI were used as classification features to discriminate between weed-infested and weed-free soybean. Spectral response for all bands and NDVI were often higher in weed-infested soybean than in weed-free soybean. Weed infestations were discriminated from weed-free soybean with at least 90% accuracy. Discriminant analysis models formed from one image were 78 to 90% accurate in discriminating weed infestations for other images obtained from the same and other experiments. Multispectral imagery has the potential for discriminating late-season weed infestations across a range of crop growth stages by using discriminant models developed from other imagery data sets.

Field research was conducted to determine the potential of hyperspectral remote sensing for discriminating plots of soybean intermixed with pitted morningglory and weed-free soybean with similar and different proportions of vegetation ground cover. Hyperspectral data were collected using a handheld spectroradiometer when pitted morningglory was in the cotyledon to two-leaf, two- to four-leaf, and four- to six-leaf growth stages. Synthesized reflectance measurements containing equal and unequal proportions of reflectance from vegetation were obtained, and seven 50-nm spectral bands (one ultraviolet, two visible, and four near-infrared) derived from each hyperspectral reflectance measurement were used as discrimination variables to differentiate weed-free soybean and soybean intermixed with pitted morningglory. Discrimination accuracy was 93 to 100% regardless of pitted morningglory growth stage and whether equal or unequal proportions of reflectance from vegetation existed in weed-free soybean and soybean intermixed with pitted morningglory. Discrimination accuracy was 88 to 98% when using the discriminant model developed for one experiment to discriminate soybean intermixed with pitted morningglory and weed-free soybean plots of the other experiment. Reflectance in the near-infrared spectrum was higher for weed-free soybean compared with soybean intermixed with pitted morningglory, and this difference affected the ability to discriminate weed-free soybean from soybean intermixed with pitted morningglory.

Field studies were conducted in 2005 and 2006 to determine the most effective chemical options within three individual herbicide-based burndown programs, glyphosate, paraquat and glufosinate, for controlling glyphosate-resistant horseweed in Mississippi. Burndown treatments were applied April 5, 2005 and March 15, 2006 to horseweed plants 15 to 30 cm in height. Glyphosate at 0.86 kg ae/ha alone provided 60 to 65% horseweed control 4 wk after treatment (WAT). Control 4 WAT ranged from 73 to 74% when the glyphosate rate was increased to 1.25 kg/ha. Glyphosate at 0.86 kg/ha applied in combination with 2,4-D at 0.84 kg ae/ha or dicamba at 0.28 ae/ha maximized control of horseweed (≥ 90%) 4 WAT and soybean yield. Horseweed control 4 WAT with paraquat alone at 0.84 kg ai/ha ranged from 55 to 63% and control did not improve by increasing the rate to 0.98 kg/ha. Addition of 2,4-D or dicamba to paraquat maximized horseweed control both years (78 to 89%), whereas soybean yield was maximized with addition of dicamba or metribuzin at 0.42 kg ai/ha. Glufosinate applied alone at 0.47 kg ai/ha resulted in at least 88% control of horseweed and maximized soybean yield. Results indicate that effective management of glyphosate-resistant horseweed can be obtained in glyphosate-resistant soybean in glyphosate-, paraquat-, and glufosinate-based preplant weed control programs.

Objectives: Rapid reviews are characterized as an accelerated evidence synthesis approach with no universally accepted methodology or definition. This modified Delphi consensus study aimed to develop a comprehensive set of defining characteristics for rapid reviews that may be used as a functional definition.

Methods: Expert panelists with knowledge in rapid reviews and evidence synthesis were identified. In the first round, panelists were asked to answer a seventeen-item survey addressing a variety of rapid review topics. Results led to the development of statements describing the characteristics of rapid reviews that were circulated to experts for agreement in a second survey round and further revised in a third round. Consensus was reached if ≥70 percent of experts agreed and there was stability in free-text comments.

Results: A panel of sixty-six experts participated. Consensus was reached on ten of eleven statements describing the characteristics of rapid reviews. According to the panel, rapid reviews aim to meet the requirements and timelines of a decision maker and should be conducted in less time than a systematic review. They use a variety of approaches to accelerate the evidence synthesis process, tailor the methods conventionally used to carry out systematic reviews, and use the most rigorous methods that the delivery time frame will allow.

Conclusions: This study achieved consensus on ten statements describing the defining characteristics of rapid reviews based on the opinion of a panel of knowledgeable experts. Areas of disagreement were also highlighted. Findings emphasize the role of the decision maker and stress the importance of transparent reporting.