The 57Fe Mössbauer spectra of six nontronite samples were measured at appropriate temperatures of 4.2 and 1.3 K. Three of the nontronites gave a complex magnetic hyperfine spectrum showing magnetic ordering at 4.2 K, and the other three required a lower temperature of 1.3 K to produce similar magnetic ordering. The spectra were computer-fitted with three closely overlapping sextets which are considered to arise from: (1) Fe3+ that is ordered magnetically in the cis-octahedral sites with a greater number of neighboring tetrahedral Fe3+ ions (51 T); (2) the cis-octahedral site with the greater number of neighboring Si4+ ions (46 T); and (4) the tetrahedral sites (41 T). In an untreated sample a further sextet corresponding to interlayer Fe3+ (36 T) was identified. The magnetic ordering was complicated and not directly related to the iron content of these sites. It probably depended also on the overall composition and structural order of the particular nontronite. The ordering appears to have been essentially two-dimensional, consistent with the layer structure of this material.

Research showing that risk for schizophrenia, bipolar disorder with psychosis, and other psychosis-spectrum diagnoses in adulthood is multidetermined has underscored the necessity of studying the additive and interactive factors in childhood that precede and predict future disorders. In this study, risk for the development of psychosis-spectrum disorders was examined in a 2-generation, 30-year prospective longitudinal study of 3,905 urban families against a sociocultural backdrop of changing economic and social conditions. Peer nominations of aggression, withdrawal, and likeability and national census information on neighborhood-level socioeconomic disadvantage in childhood, as well as changes in neighborhood socioeconomic conditions over the lifespan, were examined as predictors of diagnoses of schizophrenia, bipolar disorder, and other psychosis-spectrum disorders in adulthood relative to developing only nonpsychotic disorders or no psychiatric disorders. Individuals who were both highly aggressive and highly withdrawn were at greater risk for other psychosis-spectrum diagnoses when they experienced greater neighborhood disadvantage in childhood or worsening neighborhood conditions over maturation. Males who were highly aggressive but low on withdrawal were at greater risk for schizophrenia diagnoses. Childhood neighborhood disadvantage predicted both schizophrenia and bipolar diagnoses, regardless of childhood social behavior. Results provided strong support for multiple-domain models of psychopathology, and suggest that universal preventive interventions and social policies aimed at improving neighborhood conditions may be particularly important for decreasing the prevalence of psychosis-spectrum diagnoses in the future.

The analysis of an acid-soluble and acid-insoluble fraction of one systematically sampled, partially dolomitized limestone bed is reported. The original lime sediment, composed principally of skeletal remains, pellets, occasional intraclasts, detrital quartz, illite, and muscovite has been modified by the addition of calcite, dolomite, and dickite cements and has been patchily replaced by dolomite, quartz, and pyrite. Rapid chemical and mineralogical variations occur over short distances, i.e. within 10 m. Fe and Mn are both present in greater concentration in dolomite than in calcite. Dolomite itself varies in overall composition within the limestones and dolostones but is always Sr-deficient. The insoluble residue is dominated by quartz. Authigenic quartz occurs but its distribution is controlled by pre-existing detrital quartz so SiO2 distribution corresponds to a detrital arrangement. TiO2 and K2O follow the distribution of SiO2 and are believed to be sited in detrital minerals, muscovite, and other unidentified minerals. Sulphur, present in pyrite, has a patchy distribution but is deficient in totally dolomitized areas suggesting removal of pyrite during dolomitization.

New intersectorial isotope data are presented for two calcites. Mendip calcite shows no detectable δ13C and δ18O differences between synchronous {214} and {014} sectors. Nottingham calcite shows a δ13C difference of 1.0‰ and a δ18O difference of 0.5‰ between synchronous {401} and {0001} sectors. Data now available for 5 different calcites show the magnitude of intersectorial fractionation is variable; the effect on δ13C is twice that on δ18O. All five natural calcites also show erratic isotopic differences between symmetrically-equivalent synchronous sectors. Intersectorial isotopic fractionation is probably widespread but its cause and quantification require further work. Synchronous intracrystalline isotopic differences should be accommodated in the interpretation of isotopic data and should influence future sampling strategy.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent a disease continuum with common genetic causes and molecular pathology. We recently identified mutations in the T-cell restricted intracellular antigen-1 (TIA1) protein as a cause of ALS +/− FTD. TIA1 is an RNA-binding protein containing a low complexity domain (LCD) that promotes the assembly of membrane-less organelles, such as stress granules (SG). Whole exome sequencing of two family members with fALS/FTD revealed a novel missense mutation in the TIA1 LCD (P362L). Subsequent screening identified five more TIA1 mutations in six additional ALS patients, but none in controls. All mutation carriers presented with weakness, behavioral abnormalities or language impairments and had a final diagnosis of ALS +/− FTD. Autopsy on five TIA1 mutation carriers showed widespread neurodegeneration with TDP-43 pathology. Round eosinophilic inclusions in lower motor neurons were a consistent feature. Cellular assays revealed abnormal SG dynamics in the presence of TIA1 mutations. In summary, missense mutations in the LCD of TIA1 are a newly recognized cause of ALS/FTD with TDP-43 pathology and strengthen the role of RNA metabolism in the pathogenesis in this disease.

Most individuals with dementia live in the community, receiving care from family or lay carers. Carers’ wellbeing, and the quality of the care they provide, depends on their resilience in the face of the challenges associated with caring for someone with dementia. However, factors associated with carers’ resilience are not yet fully understood. The aim of this review is to present a narrative synthesis of factors, materials and resources associated with carers’ resilience. Electronic and hand searches identified relevant published literature, which was narratively synthesized. A framework consisting of three inter-related domains of factors influencing carers’ resilience emerged, encompassing: social and cultural factors; properties of the care relationship; and carers’ psychological factors. Holistic assessment based on this framework can help practitioners to identify vulnerable carers and to target help on factors that help to make them vulnerable but that are amenable to change.

Reproductive aspects of the intensively traded ornamental shrimp Lysmata boggessi were examined. Abundance, reproductive biology (fecundity, reproductive output and egg size) and population structure (frequency distribution, size at sex phase change and sex phase ratio) were examined at three different fishing grounds off south and west-central Florida between May 2011 and February 2012. Fishery-dependent densities of L. boggessi varied between 2.51 ± 1.39 and 13.05 ± 9.30 shrimps per 1000 m2 at two different localities. The proportion of brooding shrimp varied considerably at one locality during two different dates, suggesting reproductive seasonality. Reproductive output increased linearly with shrimp body weight (SBW) at one locality (May 2011), but scaled negatively with SBW at a second locality (January–February 2012). Lastly, no correlation between embryo size and shrimp carapace length (CL) was recorded at one locality (May 2011), but a slight negative correlation between embryo size and CL was found at the second locality (January–February 2012). Lysmata boggessi might be experiencing trade-offs between different reproductive parameters driven by environmental, probably seasonal, conditions during the year. All of this information needs to be considered in assessing shrimp stocks and establishing a sustainable management plan.

The extent to which persistent, rather than transient, fissures (wide planar voids) can exist along upper crustal faults is important in assessing fault permeability to mineral and hydrocarbon-bearing fluids. Variscan (late Carboniferous) faults cutting Dinantian (Lower Carboniferous) limestones on the Gower peninsula, South Wales, host clear evidence for fissures up to several metres wide. Evidence includes dendritic hematite growth and elongate calcite growth into open voids, spar ball and cockade breccia formation, laminated sediment infill and void-collapse breccias. Detailed mapping reveals cross-cutting geometries and brecciation of earlier fissure fills, showing that fissures were formed during, rather than after, active faulting. Fissures therefore probably formed by geometric mismatch between displaced fault walls, rather than by solution widening along inactive faults.

Dolomite is common in parts of the Chalk Group of North Sea petroleum reservoirs. The stratigraphic distribution, microtextures, and stable isotope ratios of dolomite vary both within and between four of the North Sea chalk fields examined in this study, the Eldfisk and Tor of the Norwegian Sector, the Dan Field of the Danish Sector, and the Machar Field of the United Kingdom Sector, indicating that the conditions favourable for dolomitization occurred at different times and places in the North Sea Central Graben. Dolomitization in all of the examined fields occurred late during diagenesis, after significant compactional grain breakage. Dolomite precipitation in the Eldfisk, Dan, and Machar fields occurred in modified sea water, which had Σ18O values between the assumed Cretaceous/Tertiary seawater value −1 and +8‰ (SMOW). The enrichment in 18O was probably the product of calcite recrystallization at elevated temperatures in a low water/rock ratio system. The timing of dolomitization varied with respect to organic diagenesis; dolomite precipitation in the Eldfisk Field coincided with bacterial methanogenesis whereas dolomite precipitation in the Machar Field probably coincided with bacterial sulphate reduction. The magnesium in the dolomite may have been derived from the neomorphism of high magnesium calcite to low magnesium calcite.

Laser ablation techniques permit the determination of the stable isotopic ratios of finely crystalline calcite cements in chalks for the first time. Modelling of fluid–rock interaction using whole rock and laser ablation stable isotopic data indicates that carbonate mineral diagenesis in the Eldfisk Field consisted largely of the dissolution and reprecipitation of calcite with little associated loss of porosity. Cementation by calcite derived from stylolites apparently occurred throughout the Eldfisk Field chalk, but had only a subsidiary effect on whole rock isotopic ratios. Oxygen isotopic data indicates a pore water temperature of 50–80 °C during the bulk of chalk recrystallization. Increases in whole rock δ13C values with depth are likely the result of bacterial methanogenesis during chalk recrystallization.

If P=a+b−c−d, and K=cd−ab, the solution of the equation

may be most readily found by putting (x−a)(x−b)=z2; whence (x−c)(x−d)=z2+Px+K, and therefore =z2−2ez+e2, and finally x is given by the equation

Proliferative enteropathy (PE; ileitis) is a common intestinal disease affecting susceptible pigs raised under various management systems around the world. Major developments in the understanding of PE and its causative agent, Lawsonia intracellularis, have occurred that have led to advances in the detection of this disease and methods to control and prevent it. Diagnostic tools that have improved overall detection and early onset of PE in pigs include various serological and molecular-based assays. Histological tests such as immunohistochemistry continue to be the gold standard in confirming Lawsonia-specific lesions in pigs post mortem. Despite extreme difficulties in isolating L. intracellularis, innovations in the cultivation and the development of pure culture challenge models, have opened doors to better characterization of the pathogenesis of PE through in vivo and in vitro L. intracellularis–host interactions. Advancements in molecular research such as the genetic sequencing of the entire Lawsonia genome have provided ways to identify various immunogens, metabolic pathways and methods for understanding the epidemiology of this organism. The determinations of immunological responsiveness in pigs to virulent and attenuated isolates of L. intracellularis and identification of various immunogens have led to progress in vaccine development.

Microdamage in bone contributes to the loss of bone quality in osteoporosis and is thought to play a major role in both fragility and stress fractures (Schaffler et al. 1995). In this study, in vivo microcracks in human ribs were bulk-stained in basic fuchsin and viewed in longitudinal section and in 3 dimensions using 2 different computer-based methods of reconstruction: (1) serial sectioning of methylmethacrylate embedded sections using a sledge macrotome and identification of microcracks using UV epifluorescence followed by computerised reconstruction of microcracks using software and (2) laser scanning confocal microscopy of thick sections followed by reconstruction of microcracks into a 3-D image. The size and shape of microcracks were found to be similar using both techniques. Both techniques of reconstruction showed microcracks to be approximately elliptical in shape. From the serial sectioning reconstructions (n = 9), microcracks were found to have a mean length of 404±145 μm (mean±S.D.) (in the longitudinal direction) and mean width of 97±38 μm (in the transverse direction). Using epifluorescence microscopy, 92 microcracks were identified; mean microcrack length was 349±100 μm in the longitudinal direction. This was consistent with other results (Burr & Martin, 1993) and with the theoretical prediction of an elliptical crack shape with aspect ratio (longitudinal[ratio ]transverse) of 5[ratio ]1 deduced from analysis of random 2-D sections (Taylor & Lee, 1998). The results obtained provide new data on the nature of microcracks in bone and the method has the potential to become a useful tool in the calculation of stress intensity values which indicate the probability of an individual microcrack propagating to cause a stress or fragility fracture.

Wood-grained chert is an unusual type of banded nodular chert that is characterized by alternating thin dark-coloured bands and thicker light-coloured bands, which give the chert a texture reminiscent of the growth rings of wood. The wood-grained texture found in some chert nodules in the Portland Limestone Formation of southern England is the result of variations in the concentration of calcite inclusions within the chert. Light-coloured bands contain more abundant calcite inclusions than adjoining darker coloured chert bands. The Portland Limestone wood-grained cherts formed by the late diagenetic replacement of a highly compacted carbonate sand, in which abundant siliceous sponge spicules were the silica source. Oxygen and hydrogen isotope data (δ18O=27.0 to 29.3‰; δ18O=−71 to −91‰ V-SMOW), indicate that either chert formation or, more likely, the opal-CT to quartz transformation, occurred in meteoric or mixed marine and meteoric pore waters at temperatures in the range of 20–60°C. The wood-grained texture likely formed by a self-organization process. A feedback mechanism is proposed for the origin of the texture in which calcium and carbonate ions released during the replacement of the host limestone resulted in calcite supersaturation along the boundaries of growing chert nodule. Calcite inclusion-rich chert bands formed within the calcite supersaturated zone and inclusion-poor bands formed outside of the calcite-supersaturated zone. Wood-grained chert provides another example of how the coupling of reaction and transport can produce repetitive patterns in otherwise unordered sediments or rock.

Two important factors for understanding the physical nature of compact steep spectrum (CSS) radio sources are determining the correct radio morphological classification of these objects together with their characteristics in wavebands different from the radio (Fanti et al. 1995, A&A, 302, 317). Seven CSS sources (linear dimensions < 30kpc for Ho = 50 kms–1Mpc–1 and α > 0.5, S ≃ v–α) have been found in a complete sample of strong southern radio sources. This group of CSS sources is particularly interesting because some optical and X-ray information is already available as part of a more general study of southern radio sources (Morganti et al. & Siebert et al. these Proceedings). The spectra of all the sources were presented in Tadhunter et al. (1993, MNRAS, 263, 999.) Here we present VLBI observations for three of these sources (0252-71, 1306-09 and 1814-63). The remaining four have already been imaged with VLBI (King et al. these Proceedings).

The excavations of the cemetery groups at Balneaves, Loanleven and Park of Tongland facilitate an examination of many aspects of Bronze Age burial practices in Scotland. They are notable as much for the differences in burial ritual they imply as for the very narrow chronological period in which they were used. The three sites produced a total of seventeen 14C dates, two of which are aberrant, with means of the remaining fifteen falling within a period of 250 years (3370–3610 bp in radiocarbon years). The excavations were sponsored by Historic Scotland (formerly Historic Buildings and Monuments, Scotland).

At Balneaves, a penannular ditch enclosed sixteen features, including a group of seven pits with cremation burials, four of which were associated with a distinctive assemblage of collared urns. The cremated bone was well preserved. At least one large standing stone had been erected on the site, and this was buried in the medieval period.

At Loanleven, only a segment of the enclosing ring-ditch survived, within which were four cists, two containing inhumations and two cremations, one of the latter (Cist 2) associated with a fragment of a food vessel. A decorated slab, in so-called ‘Passage Grave Style’, was recovered from Cist 1, and the same cist produced palynological evidence for grave furnishings in the form of a mat of plant material which probably underlay the body. 14C dates give a terminus ante quem of 3620±50 bp (GU–2543) for the re-use of the decorated slab, and a terminus post quem of 3410±50 bp (GU–2542) for the food vessel grave.

Park of Tongland, regarded as a Four-Poster stone circle, was excavated after the fall of a standing stone. It was shown to be of multi-period construction, consisting of a cairn which overlay seven pits containing fragmentary cremation burials, two associated with collared urns. The standing stones may not all have been erect at the same time. A series of 14C dates fell within the range of 1480–1530 bc.

The education of actuarial students has been a problem for the profession almost since its inception. Despite considerable efforts to seek improvements, difficulties have repeatedly arisen in the examinations, the syllabus and the teaching.

Over the past five years the profession has identified four major areas of concern:

—The average time to qualification of those who complete the exams is too long.

—The proportion of entrants who never qualify is too high.

—It is becoming difficult to recruit enough students to produce the required number of qualified actuaries 4–10 years later.

—There are insufficient actuaries available to fulfil the tutoring and examining duties required by the education service.

The first three of these points can be illustrated by considering a single cohort. In 1980, 289 students enrolled in the Institute. Only 5% of these had completed the exams within 4 years, and only 14% within 5 years. It is unlikely that more than about 30% of this cohort will ever qualify. Incidentally, much of the careers literature available to these students indicated that a diligent (but not extraordinary) student could expect to qualify in 3 or 4 years.

Upland sheep production systems based on the utilisation of enclosed sown pastures are considered in relation to environmental constraints, recent trends in marketing requirements and a continuing need to improve economic efficiency. The need for quantitatively described decision making in relation to both the testing, development and application of new technology is discussed with particular reference to those factors influencing herbage growth, utilisation and management.

Relatively few upland farms are capable of producing marketable fat lambs before the decline in returns per kg lamb in June. Although higher returns for heavier fat or store lambs can be obtained in the autumn, the degree to which this maximizes the returns per ha will be dependent upon the stocking rate and ewe and lamb performance during the summer. It will also be dependent on the extent to which there is competition for pasture in the autumn and its effect on ewe live weight and condition during the pre-mating and post-mating period; weight and condition will affect reproductive performance which has a substantial effect on returns per ha.

The significance of sward height as a means of controlling the performance of sheep grazing sown pastures is reviewed in relation to ongoing and completed systems experiments and development projects. It is concluded that, for practical purposes, a sward height held between 3.5 and 5.5 cm will provide a sound basis for management of the lactating ewe and suckling lamb until weaning. The means of achieving sward height control in varying farming situations and the development of commercially viable management systems is considered.

In the development of systems towards improving production efficiency, a better description of responses to both level and pattern of N used is required. The need for a better understanding of responses of the ewe in terms of ovulation rate and embryo wastage to changing sward characteristics in the autumn and to the use of supplementary feeding is also required. New techniques, such as the endocrine manipulation of reproductive performance, need to be assessed in relation to existing practices and performance.