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Human trafficking is a crime and a human rights violation that involves various and simultaneous traumatic events (sexual and physical violence, coercion). Yet, it is unknown how the patterning of violence and coercion affects the mental health of female and male trafficking survivors.
We conducted a cross-sectional study using a sample of 1015 female and male survivors of trafficking who received post-trafficking assistance services in Cambodia, Thailand or Vietnam. We assessed symptoms of anxiety and depression with the Hopkins Symptoms Checklist and symptoms of post-traumatic stress disorder (PTSD) with the Harvard Trauma Questionnaire. Violence was measured with questions from the World Health Organization International Study on Women's Health. Latent class analysis (LCA) was used to identify distinct patterns of violence and coercion in females and males. Novel multi-step mixture modelling techniques were employed to assess the association of the emergent classes with anxiety, depression and PTSD in females and males.
LCA identified two distinct classes of violence and coercion experiences in females (class I: severe sexual and physical violence and coercion (20%); class II: sexual violence and coercion (80%)) and males (class I: severe physical violence and coercion (41%); class II: personal coercion (59%)). Females in class I had a two-fold increase in the odds of anxiety (OR = 2.10; 95% CI: 1.57–2.81) and PTSD (OR = 2.07; 95% CI: 1.03–4.17) compared with females in class II, but differences in the prevalence of anxiety, depression and PTSD were not significant when comparing males in class I to class II.
Specific patterns of violence and coercion provide a more in-depth understanding of the role of gender in the experience of violence and coercion and its association with mental health in survivors of trafficking. This information could be useful to target comprehensive mental health services for female and male trafficking survivors.
Our aim is to present a new and so far most complete catalog of optically selected young stars. The basis of this work is an extensive literature search for young stars in all the known nearby (< 2 kpc) star forming regions, included in the Handbook of Star Forming Regions [4, 5], and in 67 additional catalogs. We collected data on known young, pre-main-sequence stars detected in optical bands. The catalog contains the celestial coordinates, object names, names of the enclosing star forming region, identification methods, distances, and other information (e.g., references, binarity) for 15208 young stellar objects. It is already in use by the Gaia Photometric Science Alerts Team to identify variable young stars in the Gaia data. Our catalog was cross-correlated with the Gaia DR2 and we obtained flux and distance estimations for 86% of the stars.
Cryo-electron microscopy (cryo-EM) is a powerful tool for macromolecular to near-atomic resolution structure determination in the biological sciences. The specimen is maintained in a near-native environment within a thin film of vitreous ice and imaged in a transmission electron microscope. The images can then be processed by a number of computational methods to produce three-dimensional information. Recent advances in sample preparation, imaging, and data processing have led to tremendous growth in the field of cryo-EM by providing higher resolution structures and the ability to investigate macromolecules within the context of the cell. Here, we review developments in sample preparation methods and substrates, detectors, phase plates, and cryo-correlative light and electron microscopy that have contributed to this expansion. We also have included specific biological applications.
Because depressive illness is recurrent, recurrence prevention should be a mainstay for reducing its burden on society. One way to reach this goal is to identify malleable risk factors. The ability to attenuate sadness/dysphoria (mood repair) and parasympathetic nervous system functioning, indexed as respiratory sinus arrhythmia (RSA), are impaired during depression and after it has remitted. The present study therefore tested the hypothesis that these two constructs also may mirror risk factors for a recurrent major depressive episode (MDE).
At time 1 (T1), 178 adolescents, whose last MDE had remitted, and their parents, reported on depression and mood repair; youths’ RSA at rest and in response to sad mood induction also were assessed. MDE recurrence was monitored until time 2 (T2) up to 2 years later. Mood repair at T1 (modeled as a latent construct), and resting RSA and RSA response to sadness induction (RSA profile), served to predict onset of first recurrent MDE by T2.
Consistent with expectations, maladaptive mood repair predicted recurrent MDE, above and beyond T1 depression symptoms. Further, atypical RSA profiles at T1 were associated with high levels of maladaptive mood repair, which, in turn, predicted increased risk of recurrent MDE. Thus, maladaptive mood repair mediated the effects of atypical RSA on risk of MDE recurrence.
This study documented that a combination of behavioral and physiological risk factors predicted MDE recurrence in a previously clinically referred sample of adolescents with depression histories. Because mood repair and RSA are malleable, both could be targeted for modification to reduce the risk of recurrent depression in youths.
We created the Herschel1 Footprint Database and web services for the Herschel Space Observatory imaging data. For this database we set up a unified data model for the PACS and SPIRE Herschel instruments, from the pointing and header information of each observation, generated and stored sky coverages (footprints) of the observations in their exact geometric form. With this tool we extend the capabilities of the Herschel Science Archive by providing an effective search tool that is able to find observations for selected sky locations (objects), or even in larger areas in the sky.
The Herschel Space Observatory was the fourth cornerstone mission in the European Space Agency (ESA) science programme with excellent broad band imaging capabilities in the sub-mm and far-infrared part of the spectrum. Although the spacecraft finished its observations in 2013, it left a large legacy dataset that is far from having been fully scrutinised and still has a large potential for new scientific discoveries. This is specifically true for the photometric observations of the PACS and SPIRE instruments. Some source catalogues have already been produced by individual observing programs, but there are many observations that risk to remain unexplored. To maximise the science return of the SPIRE and PACS data sets, we are in the process of building the Herschel Point Source Catalogue (HPSC) from all primary and parallel mode observations. Our homogeneous source extraction enables a systematic and unbiased comparison of sensitivity across the different Herschel fields that single programs will generally not be able to provide. The catalogue will be made available online through archives like the Herschel Science Archive (HSA), the Infrared Science Archive (IRSA), and the Strasbourg Astronomical Data Center (CDS).
We consider the spread of infectious disease through contact networks of Configuration
Model type. We assume that the disease spreads through contacts and infected individuals
recover into an immune state. We discuss a number of existing mathematical models used to
investigate this system, and show relations between the underlying assumptions of the
models. In the process we offer simplifications of some of the existing models. The
distinctions between the underlying assumptions are subtle, and in many if not most cases
this subtlety is irrelevant. Indeed, under appropriate conditions the models are
equivalent. We compare the benefits and disadvantages of the different models, and discuss
their application to other populations (e.g., clustered networks).
Finally we discuss ongoing challenges for network-based epidemic modeling.
Electron microscopy (EM), cryo-electron microscopy (cryo-EM), and cryo-electron tomography (cryo-ET) are essential techniques used for characterizing basic virus morphology and determining the three-dimensional structure of viruses. Enveloped viruses, which contain an outer lipoprotein coat, constitute the largest group of pathogenic viruses to humans. The purification of enveloped viruses from cell culture presents certain challenges. Specifically, the inclusion of host-membrane-derived vesicles, the complete destruction of the viruses, and the disruption of the internal architecture of individual virus particles. Here, we present a strategy for capturing enveloped viruses on affinity grids (AG) for use in both conventional EM and cryo-EM/ET applications. We examined the utility of AG for the selective capture of human immunodeficiency virus virus-like particles, influenza A, and measles virus. We applied nickel-nitrilotriacetic acid lipid layers in combination with molecular adaptors to selectively adhere the viruses to the AG surface. This further development of the AG method may prove essential for the gentle and selective purification of enveloped viruses directly onto EM grids for ultrastructural analyses.
The 18O(p, α)15N reaction rate has been extracted by means of the Trojan-Horse method. For the first time the contribution of the 20-keV peak has been directly evaluated, giving a value about 35% larger than previously estimated. The present approach has allowed to improve the accuracy of a factor 8.5, as it is based on the measured strength instead of educated guesses or spectroscopic measurements. The contribution of the 90-keV resonance has been determined as well, which turned out to be of negligible importance to astrophysics.
PILOT (the Pathfinder for an International Large Optical Telescope) is a proposed 2.5-m optical/infrared telescope to be located at Dome C on the Antarctic plateau. The atmospheric conditions at Dome C deliver a high sensitivity, high photometric precision, wide-field, high spatial resolution, and high-cadence imaging capability to the PILOT telescope. These capabilities enable a unique scientific potential for PILOT, which is addressed in this series of papers. The current paper presents a series of projects dealing with the nearby Universe that have been identified as key science drivers for the PILOT facility. Several projects are proposed that examine stellar populations in nearby galaxies and stellar clusters in order to gain insight into the formation and evolution processes of galaxies and stars. A series of projects will investigate the molecular phase of the Galaxy and explore the ecology of star formation, and investigate the formation processes of stellar and planetary systems. Three projects in the field of exoplanet science are proposed: a search for free-floating low-mass planets and dwarfs, a program of follow-up observations of gravitational microlensing events, and a study of infrared light-curves for previously discovered exoplanets. Three projects are also proposed in the field of planetary and space science: optical and near-infrared studies aimed at characterising planetary atmospheres, a study of coronal mass ejections from the Sun, and a monitoring program searching for small-scale Low Earth Orbit satellite debris items.
PILOT (the Pathfinder for an International Large Optical Telescope) is a proposed 2.5-m optical/infrared telescope to be located at Dome C on the Antarctic plateau. Conditions at Dome C are known to be exceptional for astronomy. The seeing (above ∼30 m height), coherence time, and isoplanatic angle are all twice as good as at typical mid-latitude sites, while the water-vapour column, and the atmosphere and telescope thermal emission are all an order of magnitude better. These conditions enable a unique scientific capability for PILOT, which is addressed in this series of papers. The current paper presents an overview of the optical and instrumentation suite for PILOT and its expected performance, a summary of the key science goals and observational approach for the facility, a discussion of the synergies between the science goals for PILOT and other telescopes, and a discussion of the future of Antarctic astronomy. Paper II and Paper III present details of the science projects divided, respectively, between the distant Universe (i.e. studies of first light, and the assembly and evolution of structure) and the nearby Universe (i.e. studies of Local Group galaxies, the Milky Way, and the Solar System).
We present the results of space-based photometric and ground-based spectroscopic observing campaigns on the γ-ray binary LS 5039. The new orbital and physical parameters of the system are similar to former results, except we found a lower eccentricity. Our MOST-data show that any broad-band optical photometric variability at the orbital period is below the 2 mmag level. Light curve simulations support the lower value of eccentricity and imply that the mass of the compact object is higher than 1.8 M⊙.
Companions exert adverse effects on the relationships valid for Cepheids. Physical
companions may also cause observable effects (e.g., phase jump in the
pulsation, slight excitation of non-radial modes). Many new binaries among Cepheids can be
revealed by using radial velocity measurements to be made by Gaia and by deriving
astrometric orbit from data to be obtained over the five years of the Gaia mission.
Cluster membership of Cepheids also facilitates the calibration of the period-luminosity
relationship independently of the pulsation. A brief summary on the membership of Cepheids
in clusters is also given.
The aim of this study was to compare cardiac output measurements of the non-invasive cardiac output and the pulmonary artery catheter during repeat surgery for hip replacement.
In this prospective observational study, patients undergoing repeat hip surgery who needed a pulmonary artery catheter were included. A standard protocol was followed for induction, endotracheal intubation and maintenance of anaesthesia (sufentanil, etomidate, sevoflurane, cisatracurium). After endotracheal intubation, the non-invasive cardiac output was connected and a pulmonary artery catheter was inserted. Data were collected every 3 min until patients were extubated.
Ten patients were included and 2455 points of comparison recorded. Cardiac output from the pulmonary artery catheter varied from 1.7 to 8.9 L min−1 (mean 4.1 L min−1) and the non-invasive cardiac output (using averaging mode) from 1.7 to 8.0 L min−1 (mean 3.7 L min−1). There was a significant correlation between them (P < 0.01; bias 0.3 L min−1; limits of agreement +1.9 and –2.5 L min−1), although these differed between patients.
The perioperative bias was small and the non-invasive cardiac output slightly underestimated cardiac output intraoperatively compared to the pulmonary artery catheter. The bias was smaller when mean cardiac output was below 3 L min−1. Core temperature between 34.4°C and 37.6°C had no influence on the differences.
Background: The aim of this prospective study was to compare continuous cardiac output measurements of the non-invasive cardiac output system (NICO) with the pulmonary artery catheter during off-pump coronary bypass surgery. Methods: Twenty-two patients enrolled for off-pump coronary surgery received both a pulmonary artery catheter and a non-invasive cardiac output system for measurement of cardiac output. Data were compared by the Bland–Altman method to calculate the degree of agreement and to analyse if a significant difference existed between the two methods of cardiac output measurements. Results: Perioperatively, the non-invasive cardiac output underestimated cardiac output, but postoperatively overestimated it. The limits of agreement were larger during surgery compared to the postoperative period (−3.1; +2.5 vs. −1.4; +2.2 L min−1). Perioperatively, cardiac output measured with the pulmonary artery catheter varied from 0.5 to 7.5 L min−1 (mean 3.6 L min−1) and with the non-invasive cardiac output from 0.5 to 8.4 L min−1 (mean 3.9 L min−1). Postoperatively, these were 2.5–7.7 L min−1 (mean 4.5 L min−1) and 2.3–8.4 L min−1 (mean 4.9 L min−1), respectively. Conclusion: During off-pump cardiac surgery, the non-invasive cardiac output reliably measures cardiac output and does it more rapidly than a pulmonary artery catheter and may be more useful in order to detect rapid haemodynamic changes.