As part of the roundtable “The Responsibility to Protect in a Changing World Order: Twenty Years since Its Inception,” this essay examines the issue of norm entrepreneurship as it has been used in conjunction with the Responsibility to Protect (RtoP), twenty years after the emergence of The Responsibility to Protect report produced by the International Commission on Intervention and State Sovereignty (ICISS). It examines norm entrepreneurs with enough drive, motivation, and resources to keep RtoP on the international agenda in a changing world order, after Western middle powers, such as Canada and some European Union member states, had previously acted as indispensable norm entrepreneurs. An examination of both Western and non-Western entrepreneurship efforts to date reveals three key observations. First, RtoP champions are now facing additional challenges in today's transitional global order, where nationalistic foreign policy agendas are replacing liberal agendas, such as RtoP. Second, the drive and adaptability of non-Western norm entrepreneurs with regional ambitions mean that small states can emerge as rather-unexpected RtoP champions. Third, giving non-Western states a visible regional or international platform allows them to display leadership in reframing prevention under the RtoP framework. The last two observations point to the increasing role of non-Western states in global governance and in the promotion of prevention measures to protect the most vulnerable, which in turn increases the legitimacy of the RtoP norm itself.