Every year large numbers of rattlesnakes (Crotalus spp. and Sistrurus spp.) are collected from the wild in several states in North America. Some of these are collected purely for commercial reasons while others are collected for the traditional, although now largely commercial, ‘rattlesnake round-ups’. Together these activities may remove 300,000–500,000 snakes each year. The high level of hunting together with capture procedures that destroy habitat as well as snakes are damaging rattlesnake populations, other species, and habitat quality.