To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
THE INNATE AND ADAPTIVE IMMUNE SYSTEMS: DEFINITIONS, CONTEXT, AND CONTRASTS
Standard accounts of the immune system emphasize the antigen-specific immunity and memory afforded by the adaptive immune system, contrasting it with the “nonspecific” defenses provided by the phylogenetically more ancient innate immune system. While study of the innate immune system has undergone a recent renaissance, most immunology textbooks still present innate immunity as an initial stopgap defense that holds the line until the “real” (efficient, effective, sophisticated) adaptive immune system can take over. There are obvious flaws in such formulations. First, while adaptive immunity may usefully be seen as a single system – with its cells (B and T lymphocytes) and antigen receptors (immunoglobulins [Ig], T-cell receptors) depending directly on the evolution of the recombination-activating gene (RAG) in jawed vertebrates – innate immunity, present in all metazoans, is a congeries of pathways. “Innate immune systems” is a much better term. Second, the innate immune systems are in no way less sophisticated than the adaptive immune system, having been under evolutionary pressure for far longer. Third, the innate immune systems are not of secondary importance; the adaptive immune system is directly dependent on the former for efficient and appropriate activation. Fourth, innate immune effector mechanisms are not less effective than adaptive immune effector mechanisms.
Email your librarian or administrator to recommend adding this to your organisation's collection.