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Donor insemination (DI) has undergone radical changes in the last 25 years, for example exclusive use of frozen semen, and increasing use of DI for single women. A summary of these is presented as are the potential challenges we still face. The latter include key questions such as what are the key methods for optimising treatment. Can we improve our success rates? If so, how can this be done? Moreover, the use of DI as a research tool, often ignored, is presented.
This revised and updated second edition provides a comprehensive account of the human male gamete. Detailed overviews of human sperm production, maturation, and function - and how these processes affect and influence fertility, infertility, and assisted reproduction - are given. A wide range of new developments including proteomics, spermatogenesis, sperm-specific WW domain-binding proteins, Ca2+ signalling, DNA packaging, epididymis are explored, whilst a new chapter presents information gained from mouse genetics, highlighting how it informs male fertility research. The impact of environmental factors during pre-pubertal and pubertal stages of life is also investigated. Featuring engaging prose with chapters organized topographically, The Sperm Cell remains an essential resource for andrologists, clinical scientists, and laboratory personnel.
The years between 1258 and 67 comprise one of the most influential periods in the Middle Ages in England. This turbulent decade witnessed a bitter power struggle between King Henry III and his baronsover who should control the government of the realm. Before England eventually descended into civil war, a significant proportion of the baronage had attempted to transform its governance by imposingon the crown a programme of legislative and administrative reform far more radical and wide-ranging than Magna Carta in 1215. Constituting a critical stage in the development of parliament, the reformist movement would remain unsurpassed in its radicalism until the upheavals of the seventeenth century. Simon de Montfort, the baronial champion, became the first leader of a political movement to seize power and govern in the king's name. The essays collected here offer the most recent research into and ideas on this pivotal period. Several contributions focus upon the roles played in the political struggle by particular sections of thirteenth-century society, including the Midland knights and their political allegiances, aristocratic women, and the merchant elite in London. The events themselves constitute the second major theme of this volume, with subjects such as the secret revolution of 1258, Henry III's recovery of power in 1261, and the little studied maritime theatre during the civil wars of 1263-7 being considered.
Adrian Jobson is an Associate Lecturer at Canterbury Christ Church University.
Contributors: Sophie Ambler, Nick Barratt, David Carpenter, Peter Coss, Mario Fernandes, Andrew H. Hershey, Adrian Jobson, Lars Kjaer, John A. McEwan, Tony Moore, Fergus Oakes, H.W. Ridgeway, Christopher David Tilley, Benjamin L. Wild, Louise J. Wilkinson.
Chronic anovulation is an important cause of infertility, accounting for approximately 20% of all causes. Men should have had a semen analysis and women should have had the basic infertility work-up including an assessment of tubal patency. In 1973 the World Health Organization published a simple classification of anovulation, namely, WHO I, II and III. WHO I patients are characterized by a history of amenorrhea. WHO II is characterized by a history of oligomenorrhea, although there may be some with amenorrhea. Central obesity is a cardinal feature of women with polycystic ovary syndrome (PCOS) with an increased waist-hip ratio. WHO III is characterized by oligoamenorrhea, and may present with menopausal symptoms, such as hot flushes, night sweats, and vaginal dryness. This chapter presents the treatment for WHO I, II, and III patients. The treatment involves lifestyle modification, aromatase inhibitors, insulin-sensitizing drugs, and hyperprolactinemia.