If groundwater enters a damaged canister and comes in contact with the spent fuel, radionuclides are released into the water in the void inside the canister when fuel dissolves. Solubility limits restrict the amount of radioelements that may migrate with the water flowing from the canister. In this study the impact of variability in groundwater chemistry compositions and the impact of uncertainties in thermodynamic data on solubility limits for Np, Pb, Pu, Ra, Se, Th, U and Zr were looked into. The solubility limits for all the studied radioelements seemed to be more sensitive to uncertainties in thermodynamic data than to differences in groundwater chemistry. The sole exception was radium, where variability in water composition has a somewhat larger impact. Radium is also the most safety critical element in the safety assessment SR-Site and groundwater compositions are expected to vary during the assessment period of one million years.