To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.
A major step in the evolution of eutherian mammals was the formation of the trophoblast, a specialised layer of cells derived early in embryogenesis. From this separate compartment, trophoblast is able to organise its own programme of development within a well-defined time span that is independent of the embryo, thereby enabling it to fulfil unique functions during ontogeny. While trophoblast contributes to the formation of the placenta in all eutherians, the manner by which it does so varies significantly among species (Carter 2001). It is important to recognise the pattern and extent of these variations if dialogue between investigators using human and those using animal material is to be meaningful. The trophoblast cell itself occurs in different forms ranging from uninuclear to multinuclear varieties, the latter appearing either as large giant cells or as a syncytium. Some of the giant cells are polytenic whilst others are polyploid but it is not known why these occur in different locations and time points of gestation in different species.
Trophoblast cells have remarkable growth and invasive properties in vivo, so much so that they resemble neoplastic cells, yet the in vitro culture and propagation of human trophoblast cells have still not met with much success. The recent realisation that some ‘trophoblast’ cell lines presently available are not what they seem to be has raised questions about how these cells should be characterised (King et al. 2000).
In the light of the discovery of the major histocompatibility complex (MHC) and its role in transplantation, the seminal essay written by Medawar drew a logical comparison between an allograft and a fetus (Medawar 1953). Despite being non-self, the fetus survives while the transplant is rejected. Medawar himself pointed out that the placenta must play a central role in fetal acceptance as it is the placental trophoblast cells that interface with the mother. Now, over 50 years later, the question how the allogeneic trophoblast survives in the potentially immunological hostile uterine environment remains unanswered. Why is the solution to this problem so elusive? I would argue that comparing the placental/maternal relationship with the graft/host relationship is misleading because the analogy between the two is not as close as it appears to be.
The extent of cellular contact between trophoblast and maternal tissue will vary significantly between species depending on the type of placentation. The immunological problem is likely to be most acute in the deeply invasive haemochorial placenta used in humans so that the adaptation required and the strategy employed in human reproduction would be expected to be different from those of other species. For this reason, animal models are not very useful and extrapolation of data between species has led to much confusion. The present paper is focused on human placentation.
Reproductive immunologists have always followed mainstream immunology and tried to fit the immunology of the maternal-fetal relationship into the paradigms of the day. Attachment of the blastocyst to the uterine lining is thought to trigger the differentiation of the trophectoderm into two layers: an inner cytotrophoblast layer and an outer syncytium of syncytiotrophoblast. Adults homozygous for a highly truncated 'null' allele of human leucocyte antigen G (HLA-G) have been identified. The birth of these individuals suggests that the expression of full-length, membrane-associated HLA-G in trophoblast is not an obligate requirement for pregnancy. The various trophoblast populations differ with respect to both their expression of major histocompatibility complex (MHC) and which maternal immune cells they encounter. In humans, uterine natural killer (uNK) cells are present before implantation and in nonpregnant cycles where the number of uNK cells changes during the course of the menstrual cycle.
Email your librarian or administrator to recommend adding this to your organisation's collection.