We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
Marine radiocarbon (14C) ages are an important geochronology tool for the understanding of past earthquakes and tsunamis that have impacted the coastline of New Zealand. To advance this field of research, we need an improved understanding of the radiocarbon marine reservoir correction for coastal waters of New Zealand. Here we report 170 new ΔR20 (1900–1950) measurements from around New Zealand made on pre-1950 marine shells and mollusks killed by the 1931 Napier earthquake. The influence of feeding method, living depth and environmental preference on ΔR is evaluated and we find no influence from these factors except for samples living at or around the high tide mark on rocky open coastlines, which tend to have anomalously low ΔR values. We examine how ΔR varies spatially around the New Zealand coastline and identify continuous stretches of coastline with statistically similar ΔR values. We recommend subdividing the New Zealand coast into four regions with different marine reservoir corrections: A: south and western South Island, ΔR20 –113 ± 33 yr, B: Cook Strait and western North Island, ΔR20 –171 ± 29 yr, C: northeastern North Island, ΔR20 –143 ± 18 yr, D: eastern North Island and eastern South Island, ΔR20 –70 ± 39 yr.
This chapter seeks to identify the doctrinal content of Trent’s decrees on the Eucharist, and to understand its engagement with Protestant teaching, in three areas: Christ’s presence in the Eucharist; communion in both kinds; and the Eucharist as sacrifice.
A number of coins issued during the years 49–44 had on them an additional legend, a trend which had been developing in the preceding fifty years, but which was used much more extensively by Caesar's moneyers. The legends (with two exceptions) all refer to recognised ‘qualities’, which had temples and cults established in the Roman community. The coin types, particularly in the opening years of the civil war between Caesar and Pompeius, were issued in very large numbers, suggesting that they were not only used to pay the troops whom Caesar had already and those he was recruiting, but also that they were put into general circulation. The qualities emphasised on the coins indicate Caesar's programmatic ideology, and the number issued shows that he wished to circulate this ideology widely. The additional legends can be taken therefore to be ‘slogans’, a form of propaganda for Caesar's aims. The two exceptions were Pax and Clementia, but there is evidence to suggest that a cult and temple were planned for each of these.
Hurricane Sandy made landfall in New Jersey on October 29, 2012, resulting in widespread power outages and gasoline shortages. These events led to potentially toxic exposures and the need for information related to poisons/toxins in the environment. This report characterizes the New Jersey Poison Information and Education System (NJPIES) call patterns in the days immediately preceding, during, and after Hurricane Sandy to identify areas in need of public health education and prevention.
Methods:
We examined NJPIES case data from October through December 2012. Most Sandy-related calls had been coded as such by NJPIES staff. Additional Sandy-related cases were identified by performing a case narrative review. Descriptive analyses were performed for timing, case frequencies, exposure substances, gender, caller site, type of information requests, and other data.
Results:
The most frequent Sandy-related exposures were gasoline and carbon monoxide (CO). Gasoline exposure cases were predominantly males and CO exposure cases, females (P < 0.0001). Other leading reasons for Sandy-related calls were poison information, food poisoning/spoilage information, and water contamination.
Conclusions:
This analysis identified the need for enhanced public health education and intervention to improve the handling of gasoline and encourage the proper use of gasoline-powered generators and cleaning and cooking equipment, thus reducing toxic exposures.
Healthcare personnel (HCP) were recruited to provide serum samples, which were tested for antibodies against Ebola or Lassa virus to evaluate for asymptomatic seroconversion.
Setting:
From 2014 to 2016, 4 patients with Ebola virus disease (EVD) and 1 patient with Lassa fever (LF) were treated in the Serious Communicable Diseases Unit (SCDU) at Emory University Hospital. Strict infection control and clinical biosafety practices were implemented to prevent nosocomial transmission of EVD or LF to HCP.
Participants:
All personnel who entered the SCDU who were required to measure their temperatures and complete a symptom questionnaire twice daily were eligible.
Results:
No employee developed symptomatic EVD or LF. EVD and LF antibody studies were performed on sera samples from 42 HCP. The 6 participants who had received investigational vaccination with a chimpanzee adenovirus type 3 vectored Ebola glycoprotein vaccine had high antibody titers to Ebola glycoprotein, but none had a response to Ebola nucleoprotein or VP40, or a response to LF antigens.
Conclusions:
Patients infected with filoviruses and arenaviruses can be managed successfully without causing occupation-related symptomatic or asymptomatic infections. Meticulous attention to infection control and clinical biosafety practices by highly motivated, trained staff is critical to the safe care of patients with an infection from a special pathogen.
In a recent article in this journal, Kathryn Welch and Hannah Mitchell examined a much debated question: to what extent did Roman commanders, and in particular Pompeius, model themselves on Alexander the Great?1 The opposing views on this question are best encapsulated by Peter Green on the one side, and Erich Gruen on the other.2 One piece of evidence used in this continuing debate is an aureus of Pompeius, but there are two disputes related to it: the date of its issue and the iconography of its obverse. Unfortunately, due to a lack of specific evidence the discussion trying to resolve these disputes often ends without a clear conclusion, and we are left with speculation and conjecture.
The reverse of the aureus shows a triumph, and the nub of the question about dating the coin is which triumph does it depict. The argument here is that the coin depicts Pompeius’ third triumph in 61 BC, when he celebrated his extensive conquests in the East. That date will help the argument that the personification on the obverse has Alexander overtones, as some scholars suggest. If that can be established, it will give some idea of Pompeius’ intentions in minting the coin: Pompeius was not only channelling Alexander, but also trying to imply that he had surpassed the Macedonian king’s achievements.
We analyze relationships among a range of ecological and biological traits—geographic range size, body size, life mode, larval type, and feeding type—in order to identify those traits that are associated significantly with species duration in New Zealand Cenozoic marine molluscs, during a time of background extinction. Using log-linear modeling, we find that bivalves have only a small number of simple, two-way associations between the studied traits and duration. In contrast, gastropods display more complex interactions involving three-way associations between traits, a pattern that suggests greater macroecological complexity of gastropods. This is not an artifact caused by the larger number of gastropods than bivalves in our data set. We used stratified randomized resampling of families to test for associations between traits that might result from shared inheritance rather than ecological trait interactions; we found no evidence of phylogenetic effects in any associations examined. The relationships revealed by our study should serve to constrain the range of possible biological mechanisms that underlie these relationships. As previously observed, two-way associations are present between large geographic range and increased duration, and between large geographic range and large body size, in both bivalves and gastropods. In gastropods, planktotrophic larval type is associated with large range size through a three-way interaction that also involves duration; there is no direct association of larval type and geographic range. Gastropods also display two-way associations between duration and life mode, and duration and feeding type. We note that in gastropods, an infaunal life mode is associated with large range size, whereas in bivalves infaunality is associated with reduced range size.
In recent years several authors have questioned the reality of a widely accepted and apparently large increase in marine biodiversity through the Cenozoic. Here we use collection-level occurrence data from the rich and uniquely well documented New Zealand (NZ) shelfal marine mollusc fauna to test this question at a regional scale. Because the NZ data were generated by a small number of workers and have been databased over many decades, we have been able to either avoid or quantify many of the biases inherent in analyses of past biodiversity. In particular, our major conclusions are robust to several potential taphonomic and systematic biases and methodological uncertainties, namely non-uniform loss of aragonitic faunas, biostratigraphic range errors, taxonomic errors, choice of time bins, choice of analytical protocols, and taxonomic rank of analysis.
The number of taxa sampled increases through the Cenozoic. Once diversity estimates are standardized for sampling biases, however, we see no evidence for an increase in marine mollusc diversity in the NZ region through the middle and late Cenozoic. Instead, diversity has been approximately constant for much of the past 40 Myr and, at the species and genus levels, has declined over the past ~5 Myr. Assuming that the result for NZ shelfal molluscs is representative of other taxonomic groups and other temperate faunal provinces, then this suggests that the postulated global increase in diversity is either an artifact of sampling bias or analytical methods, resulted from increasing provinciality, or was driven by large increases in diversity in tropical regions. We see no evidence for a species-area effect on diversity. Likewise, we are unable to demonstrate a relationship between marine temperature and diversity, although this question should be re-examined once refined shallow marine temperature estimates become available.
In spite of the economic benefits of insecticides to farmers and consumers, growing concern about the potential health and environmental hazards of some insecticides has resulted in the investigation of many insecticides by the Environmental Protection Agency (Boraiko). The use of several insecticides has already been banned. Others are under review and their use may be banned or restricted in the future.
The Environmental Protection Agency must evaluate, monitor, and regulate a wide range of chemical compounds. To do so requires the collection and analysis of information on the environmental, health, and economic impacts of the use of many diverse chemicals. Though regulatory action by the Environmental Protection Agency may reduce health and environmental risks, such action can also alter the profitability and performance of a farming operation.
The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:
1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.
2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.
The beetle-hunting wasp, Cerceris fumipennis Say (Hymenoptera: Crabronidae), native to eastern North America, provisions its subterranean nest almost exclusively with adult metallic wood-boring beetles (Coleoptera: Buprestidae), including the destructive emerald ash borer (Agrilus planipennis Fairmaire, EAB). This wasp provides a unique opportunity to survey indigenous and nonindigenous buprestid diversity. We discuss the accessibility, sustainability, and productivity of C. fumipennis with respect to its application as a buprestid surveying and monitoring tool.
The Gemini Planet Imager (GPI) is a high contrast coronagraph designed to directly image exoplanets and circumstellar disks. GPI includes a polarimetry mode designed to characterize dust grains and enhance the contrast of scattered, polarized light by a factor of 100. Reflections and birefringence of optics within the optical train induce a polarization signature that needs to be measured a priori and calibrated out during data reduction. Here we report on the results of an extensive laboratory characterization campaign of the polarimetry mode. The linear instrumental polarization has been measured in 4 GPI passbands and found to be between 3.5 ± 0.3 % at 1.0 micron and 1.1 ± 0.3 % at 2.0 microns. Modulation efficiency has been measured to be 94% at 1.0 micron increasing to 97% at 2.0 microns. Stability has been shown to better than 0.6% over timescales of ~ 3 months and over cool down cycles. The tests show that GPI passes all polarimetry design requirements and should be able to measure circumstellar disk linear polarization to 1% accuracy.
Erich Gruen long ago put forward the view that, in the twenty-five years or so before the introduction of the lex Calpurnia, the senate saw that it was losing control of foreign policy and that tribunes were playing a larger role in stirring up popular outrage at the conduct of provincial governors. Therefore, he claims, the senate felt that something had to be done. Gruen and others also stress that the catalyst for the introduction of the lex Calpurnia arose from atrocities committed by Sulpicius Galba in 150. The first part of this article examines a whole series of atrocities over those twenty-five years to test how accurate these two views are, and concludes that the senate did play a large part in attempting to curb the excesses of some governors and that all the atrocities contributed to the climate of opinion which led to the establishment of the Calpumian court. The second part describes the scope, limitations and implementation of the law, leading to the conclusion that it was not really of benefit to the socii and peregrini, since actions could be brought only by Roman citizens or by patroni acting on their behalf.
This volume is a synthesis of current knowledge about the growth, development and functioning of plant canopies. The term canopy is taken to include not only the upper surface of woodland, as in the original definition, but also analogous surfaces of other plant communities. Although much research has been carried out on single leaves, canopies are much more than just a collection of individual leaves, and so exhibit properties of their own. It can be argued that it is primarily at the canopy rather than the leaf level that solutions to many practical problems about the growth of plants in the field can be found. In this volume, canopy properties are considered in terms of the processes, such as transpiration and photosynthesis, by which the canopy and its environment interact. Topics discussed include the meaning of canopy structure, interception of solar radiation, exchange processes, nitrogen nutrition, leaf demography and heliotropism. Key principles are illustrated by examples from a wide range of plant community types and geographical locations. This book will be of interest to advanced students and research workers in agriculture, botany, crop sciences, ecology and forestry.
Two closely related questions receive distinctively theological answers in this study: What is truth? and How can we tell whether what we have said is true? Bruce Marshall proposes that the Christian community's identification of God as the Trinity serves as the key to a theologically adequate treatment of these questions. Professor Marshall argues on trinitarian grounds that the Christian way of identifying God ought to have unrestricted primacy when it comes to the justification of belief, and he proposes a trinitarian way of reshaping the concept of truth. Direct engagement with the current philosophical debate about truth, meaning and belief (in Quine and others) suggests that a trinitarian account of epistemic justification and truth is also more philosophically compelling than the approaches generally favoured in modern theology, as exemplified by Schleiermacher, Ritschl, Rahner and others. Marshall offers a contemporary way of conceiving of the Christian God as 'the truth'.
The use of an ion beam assist during the concurrent deposition of cubic materials can result in the growth of crystallographically oriented thin films. A model system, magnesium oxide (MgO), has been successfully used as a biaxially textured template film and develops texture in a different manner from that of other well-studied materials, like yttria-stablized zirconia. Here, we present data on the initial nucleation of biaxial texture in this model system using a novel in-situ quartz crystal microbalance (QCM) substrate combined with in-situ reflected high-energy electron diffraction (RHEED). Temporal correlation of mass uptake with the RHEED images of the growing surface can be used to elucidate the mechanism of texture development in these films. Experimental data shows that the initially polycrystalline MgO film develops biaxial crystallographic texture at a thickness of ˜2 nm, regardless of the ion-to-molecule ratio. RHEED images show the onset of texture occurs quickly and is somewhat analogous to a solid phase re-crystallization process with crystallite sizes of ˜3 to 4 nm. Imaging with transmission electron microscopy has corroborated these observations. Changes in the ion-to-molecule ratio can influence the crystallite size and affect the nucleation density of these films. Growth of these films on various substrates changes the sticking coefficient of the MgO and influences the nucleation density and film growth mode as well. This opens the possibility of using MgO and other materials to develop biaxially textured crystallites with a narrow, specified size distribution for nanoscale applications.