We present our measurements of the amplitude of photometric and spectroscopic variability due to clumping in the wind of Wolf-Rayet (WR) stars. Photometric variability was assessed using TESS light-curves, while spectroscopic variations were obtained from almost 20 years of monitoring of nearly 100 classical (presumably single) stars. Our results show an apparent dependence of the variability amplitude with the stars’ surface temperature and/or terminal velocity. Our interpretation is that it supports the idea that the dominating driver of the clumps in WR winds is a sub-surface convection region.

We present the results of our analysis of 122 light-curves from 50 Wolf-Rayet (WR) stars using a red+white noise analysis, where we compare the fitted red noise features with stellar parameters to assess the presence of correlations with stellar parameters. A significant correlation between the amplitude of variability α0 and v∞ was found for the whole sample, along with several other correlations satisfying the Spearman-Rank p<0.001 criterion for both He-burning and WNh stars. Our results are compatible with several plausible processes that can have an influence on the level of variability in the winds of these stars, including a subsurface convection zone and core-generated internal gravity waves.

This work evaluates the fidelity of the polar marine Ekman layer in the Regional Arctic System Model (RASM) and Community Earth System Model (CESM) using sea-ice inertial oscillations as a proxy for ice-ocean Ekman transport. A case study is presented that demonstrates that RASM replicates inertial oscillations in close agreement with motion derived using the GPS. This result is obtained from a year-long case study pre-dating the recent decline in perennial Arctic sea ice, using RASM with sub-hourly coupling between the atmosphere, sea-ice and ocean components. To place this work in context, the RASM coupling method is applied to CESM, increasing the frequency of oceanic flux exchange from once per day in the standard CESM configuration, to every 30 min. For a single year simulation, this change causes a considerable increase in the median inertial ice speed across large areas of the Southern Ocean and parts of the Arctic sea-ice zone. The result suggests that processes associated with the passage of storms over sea ice (e.g. oceanic mixing, sea-ice deformation and surface energy exchange) are underestimated in Earth System Models that do not resolve inertial frequencies in their marine coupling cycle.

Field experiments were conducted at five locations in Kansas, Nebraska, and Wyoming to determine the effects of imazamox rate and application timing on winter annual grass control and crop response in imidazolinone-tolerant winter wheat. Imazamox at 35, 44, or 53 g ai/ha applied early-fall postemergence (EFP), late-fall postemergence, early-spring postemergence (ESP), or late-spring postemergence (LSP) controlled jointed goatgrass at least 95% in all experiments. Feral rye control with imazamox was 95 to 99%, regardless of rate or application timing at Hays, KS, in 2001. Feral rye control at Sidney, NE, and Torrington, WY, was highest (78 to 85%) with imazamox at 44 or 53 g/ha. At Sidney and Torrington, feral rye control was greatest when imazamox was applied EFP. Imazamox stunted wheat <10% in two experiments at Torrington, but EFP or LSP herbicide treatments in the Sidney experiment and ESP or LSP treatments in two Hays experiments caused moderate (12 to 34%) wheat injury. Wheat injury increased as imazamox rate increased. Wheat receiving imazamox LSP yielded less grain than wheat treated at other application timings in each Hays experiment and at Sidney in 2001. No yield differences occurred in one Torrington experiment. However, yields generally decreased as imazamox application timing was delayed in the other Torrington experiment. Generally, imazamox applied in the fall provided the greatest weed control, caused the least wheat injury, and maximized wheat yield.

A recent editorial claimed that the 2014 National Institute for Health and Care Excellence (NICE) guideline on psychosis and schizophrenia, unlike its equivalent 2013 Scottish Intercollegiate Guidelines Network (SIGN) guideline, is biased towards psychosocial treatments and against drug treatments. In this paper we underline that the NICE and SIGN guidelines recommend similar interventions, but that the NICE guideline has more rigorous methodology. Our analysis suggests that the authors of the editorial appear to have succumbed to bias themselves.

Maternal nutritional status during pregnancy has been reported to be associated with childhood asthma and atopic disease. The Avon Longitudinal Study of Parents and Children has reported associations between reduced umbilical cord Fe status and childhood wheeze and eczema; however, follow-up was short and lung function was not measured. In the present study, the associations between maternal Fe status during pregnancy and childhood outcomes in the first 10 years of life were investigated in a subgroup of 157 mother–child pairs from a birth cohort with complete maternal, fetal ultrasound, blood and child follow-up data. Maternal Fe intake was assessed using FFQ at 32 weeks of gestation and Hb concentrations and serum Fe status (ferritin, soluble transferrin receptor and TfR-F (transferrin receptor:ferritin) index) were measured at 11 weeks of gestation and at delivery. Maternal Fe intake, Hb concentrations and serum Fe status were found to be not associated with fetal or birth measurements. Unit increases in first-trimester maternal serum TfR concentrations (OR 1·44, 95 % CI 1·05, 1·99) and TfR-F index (OR 1·42, 95 % CI 1·10, 1·82) (i.e. decreasing Fe status) were found to be associated with an increased risk of wheeze, while unit increases in serum ferritin concentrations (i.e. increasing Fe status) were found to be associated with increases in standardised mean peak expiratory flow (PEF) (β 0·25, 95 % CI 0·09, 0·42) and forced expiratory volume in the first second (FEV1) (β 0·20, 95 % CI 0·08, 0·32) up to 10 years of age. Increasing maternal serum TfR-F index at delivery was found to be associated with an increased risk of atopic sensitisation (OR 1·35, 95 % CI 1·02, 1·79). The results of the present study suggest that reduced maternal Fe status during pregnancy is adversely associated with childhood wheeze, lung function and atopic sensitisation, justifying further studies on maternal Fe status and childhood asthma and atopic disease.

Objectives: The aim of this study was to develop a decision support tool to assess the potential benefits and costs of new healthcare interventions.

Methods: The Canadian Partnership Against Cancer (CPAC) commissioned the development of a Cancer Risk Management Model (CRMM)—a computer microsimulation model that simulates individual lives one at a time, from birth to death, taking account of Canadian demographic and labor force characteristics, risk factor exposures, and health histories. Information from all the simulated lives is combined to produce aggregate measures of health outcomes for the population or for particular subpopulations.

Results: The CRMM can project the population health and economic impacts of cancer control programs in Canada and the impacts of major risk factors, cancer prevention, and screening programs and new cancer treatments on population health and costs to the healthcare system. It estimates both the direct costs of medical care, as well as lost earnings and impacts on tax revenues. The lung and colorectal modules are available through the CPAC Web site (www.cancerview.ca/cancerrriskmanagement) to registered users where structured scenarios can be explored for their projected impacts. Advanced users will be able to specify new scenarios or change existing modules by varying input parameters or by accessing open source code. Model development is now being extended to cervical and breast cancers.

Ageing is associated with weight loss and subsequently poor health outcomes. The present study assessed agreement between two field methods, bioelectrical impedance spectroscopy (BIS) and corrected arm muscle area (CAMA) for assessment of body composition against dual-energy X-ray absorptiometry (DXA), the reference technique. Agreement between two predictive equations estimating skeletal muscle mass (SMM) from BIS against SMM from DXA was also determined. Assessments occurred at baseline < 14 d post-surgery (n 79), and at 6 months (6M; n 75) and 12 months (12M; n 63) in community-living older adults after surgical treatment for hip fracture. The 95 % limits of agreement (LOA) between BIS and DXA, CAMA and DXA and the equations and DXA were assessed using Bland–Altman analyses. Mean bias and LOA for fat-free mass (FFM) between BIS and DXA were: baseline, 0·7 ( − 10·9, 12·4) kg; 6M, − 0·5 ( − 20·7, 19·8) kg; 12M, 0·1 ( − 8·7, 8·9) kg and for SMM between CAMA and DXA were: baseline, 0·3 ( − 11·7, 12·3) kg; 6M, 1·3 ( − 4·5, 7·1) kg; 12M, 0·9 ( − 5·4, 7·2) kg. Equivalent data for predictive equations against DXA were: equation 1: baseline, 15·1 ( − 9·5, 20·6) kg; 6M, 17·1 ( − 12·0, 22·2) kg; 12M, 17·5 ( − 13·0, 22·0) kg; equation 2: baseline, 12·6 ( − 7·3, 19·9) kg; 6M, 14·4 ( − 9·7, 19·1) kg; 12M, 14·8 ( − 10·7, 18·9) kg. Proportional bias (BIS: β = − 0·337, P< 0·001; CAMA: β = − 0·294, P< 0·001) was present at baseline but not at 6M or 12M. Clinicians should be cautious in using these field methods to predict FFM and SMM, particularly in the acute care setting. New predictive equations would be beneficial.