Direct numerical simulation of the three-dimensional (3-D) wake transition of a heated square cylinder subjected to horizontal cross-flow is performed in the presence of buoyancy. In order to capture the effects of large-scale heating, a non-Oberbeck–Boussinesq model is utilized, which includes the governing equations for compressible gas flow. All computations are performed at low free stream Mach number $M=0.1$ using air (free stream Prandtl number, $Pr=0.71$) as the working fluid. The 3-D instability modes A and B, which correspond to free stream Reynolds numbers of 180 and 250, are observed with longer and shorter spanwise wavelengths, respectively, and the onset of three-dimensionality is triggered at a Reynolds number of 173. In the presence of buoyancy, baroclinic vorticity production in the near-wake plays an important role for streamwise vorticity generation. The chaotic wake of the Mode-A instability bifurcates into periodic and quasiperiodic wakes at various heating levels, expressed by the overheat ratio, $\varepsilon =(T_w-T_\infty )/T_\infty$, where $T_w$ and $T_\infty$ are the temperature of the cylinder surface and the ambient air, respectively. At low heating ($\varepsilon =0.2$), the 3-D Mode-A instability is suppressed leading to a two-dimensional wake flow. Further increase in heating, again brings back the three-dimensionality in the wake through Mode-E instability. The variation of thermophysical properties and the effective Reynolds number with increase in heating level around the cylinder is examined. It is shown that the effect of thermophysical properties competes with the baroclinic streamwise vorticity generation at higher levels of heating ($\varepsilon \geqslant 0.4$) to control the 3-D modes and wake dynamics.

In this article, we re-examine Pascal's Mugging, and argue that it is a deeper problem than the St. Petersburg paradox. We offer a way out that is consistent with classical decision theory. Specifically, we propose a “many muggers” response analogous to the “many gods” objection to Pascal's Wager. When a very tiny probability of a great reward becomes a salient outcome of a choice, such as in the offer of the mugger, it can be discounted on the condition that there are many other symmetric, non-salient rewards that one may receive if one chooses otherwise.

The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery will be the largest and most comprehensive scientific meeting dedicated to paediatric and congenital cardiac care ever held. At the time of the writing of this manuscript, The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery has 5,037 registered attendees (and rising) from 117 countries, a truly diverse and international faculty of over 925 individuals from 89 countries, over 2,000 individual abstracts and poster presenters from 101 countries, and a Best Abstract Competition featuring 153 oral abstracts from 34 countries. For information about the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery, please visit the following website: [www.WCPCCS2023.org]. The purpose of this manuscript is to review the activities related to global health and advocacy that will occur at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery.

Acknowledging the need for urgent change, we wanted to take the opportunity to bring a common voice to the global community and issue the Washington DC WCPCCS Call to Action on Addressing the Global Burden of Pediatric and Congenital Heart Diseases. A copy of this Washington DC WCPCCS Call to Action is provided in the Appendix of this manuscript. This Washington DC WCPCCS Call to Action is an initiative aimed at increasing awareness of the global burden, promoting the development of sustainable care systems, and improving access to high quality and equitable healthcare for children with heart disease as well as adults with congenital heart disease worldwide.

Named entity recognition (NER) aims to identify mentions of named entities in an unstructured text and classify them into predefined named entity classes. While deep learning-based pre-trained language models help to achieve good predictive performances in NER, many domain-specific NER applications still call for a substantial amount of labeled data. Active learning (AL), a general framework for the label acquisition problem, has been used for NER tasks to minimize the annotation cost without sacrificing model performance. However, the heavily imbalanced class distribution of tokens introduces challenges in designing effective AL querying methods for NER. We propose several AL sentence query evaluation functions that pay more attention to potential positive tokens and evaluate these proposed functions with both sentence-based and token-based cost evaluation strategies. We also propose a better data-driven normalization approach to penalize sentences that are too long or too short. Our experiments on three datasets from different domains reveal that the proposed approach reduces the number of annotated tokens while achieving better or comparable prediction performance with conventional methods.

Helicoverpa armigera (Hübner) is considered a serious agricultural pest worldwide. We explored the effects of artificial diets containing ten legumes, including broad beans (Shadan, Feyz, Saraziri, Barekat, and Mahta cultivars), white kidney beans (Dehghan cultivar), red kidney beans (Goli cultivar), common beans (Khomein cultivar), cowpeas (Mashhad and Arabi cultivars) on the feeding responses of H. armigera by quantifying specific primary and secondary metabolites in the studied legumes and determining larval nutritional indices and digestive enzyme activities. The results showed that the highest efficiency of conversion of digested food (ECD) and relative growth rate values (RGR) of whole larval instars were obtained in the Dehghan and Goli cultivars. However, the lowest values of ECD and RGR were observed in the larvae fed on the Khomein and Mahta cultivars. The highest proteolytic and amylolytic activities of larvae were found on the Dehghan and Mashhad cultivars. The highest and lowest values of standardized insect-growth index and index of plant quality were observed in larvae feeding on the Dehghan and Khomein cultivars, respectively. Additionally, significant variations in phytochemical metabolites were recorded among the studied legume cultivars. Significant negative or positive correlations were also found between feeding characteristics and enzymatic activities of H. armigera with the biochemical composition of the studied legumes. The cluster analysis results revealed that artificial diets containing Mahta and Khomein cultivars were unsuitable for H. armigera, and can be used as candidates for integrated pest management programs or for screening insect inhibitors to produce genetically modified pest-resistant plants.

Mycobacterium tuberculosis is the cause of tuberculosis (TB), a granulomatous illness that mostly affects the lungs. Pakistan is one of the eight nations that accounts for two-thirds of all new cases of developing TB. TB has long been an endemic disease in Pakistan. According to the World Health Organization (WHO) estimates, the nation has over 500 000 incident TB infections per year, with a rising number of drug-resistant cases. Recently, the coexistence of COVID-19 and TB in Pakistan has provided doctors with a problem. Fever or chills, cough, shortness of breath or difficulty breathing are all signs of COVID-19. After SARS-CoV-2 infection, cough might persist for weeks or months and it is frequently accompanied by persistent tiredness, cognitive impairment, dyspnoea or pain – a group of long-term consequences known as post-COVID syndrome or protracted COVID. Coughing with mucus or blood, and coughing that continues over 2 months are indications of TB. The same clinical presentation features make it difficult for healthcare personnel to effectively evaluate the illness and prevent the spread of these fatal diseases. Pakistan lacks the necessary healthcare resources to tackle two contagious diseases at the same time. To counteract the sudden increase in TB cases, appropriate management and effective policies must be implemented. Thus, in order to prevent the spread of these infectious diseases, it is critical to recognise and address the problems that the healthcare sector faces, as well as to create an atmosphere in which the healthcare sector can function at its full potential.

The interaction between chalcopyrite and illite particles was analysed using ζ-potential measurements and flotation tests. Statistically designed tests were used to examine the factors controlling flotation (frother concentration, dispersant concentration, froth height, airflow rate and amount of clay). Furthermore, the significance levels of the impacts of these factors on responses (chalcopyrite grade/recovery, pyrite grade/recovery, dynamic froth stability and mean bubble diameter) were determined. Chalcopyrite and pyrite ζ-potentials were measured in the presence of illite. The addition of 15% illite to the chalcopyrite, especially between pH 11 and 12, shifted the ζ-potential values closer to that of pure illite, indicating complete surface coating of chalcopyrite with illite. In the flotation experiments, better results were obtained in terms of chalcopyrite grade at a low airflow rate and a high froth height. With increasing froth height there was a decline in the gangue mineral recovery as the residence time of the froth increased. The most significant factor increasing pyrite recovery was the amount of clay. Although illite is considered to be the least problematic clay mineral for flotation, as reported in the literature, an illite content of as low as 5% in the ore decreased chalcopyrite grade by 3.83%. While K and Na contents of 4% were detected after flotation without the addition of illite, their abundance increased to 5.7% after the addition of illite.

The recommended daily dose of vitamin D is 2000 IU was found to be insufficient in many patients. The objective of the present study is to find whether the daily dose of vitamin D should be based on BMI. Two hundred and thirty patients with an established vitamin D deficiency (serum level of 25 Hydroxy vitamin D3 (25OHD3) of ≤20 ng/ml) and patients with BMI ≥30 kg/m2 were included in the study. Demographic data, comorbidities and BMI were recorded. Pre-treatment and post-treatment serum 25OHD3, calcium, phosphorus and parathyroid hormone (PTH) were tested at 0-, 3- and 6-month periods. Patients were treated with a standard dose of 50 000 IU of vitamin D weekly and 600/1200 mg of calcium a day. Once their level of 25OHD3 reached ≥30 ng/ml, patients were randomised into two groups. Group A received a standard recommended maintenance dose of 2000 IU daily and Group B patients received 125 IU/kg/m2 of vitamin D3. The data were entered in the database and analysed. The mean age of Group A was 50⋅74 ± 7⋅64 years compared to 52⋅32 ± 7⋅21 years in Group B. In both groups, pre-treatment vitamin D level was ≤15 ng/ml and increased to 34⋅6 ± 2⋅6 and 33⋅7 ± 2⋅4 ng/ml at the end of 3 months treatment with a dose 50 000 IU of vitamin D3 and calcium 600/1200 mg once a day for group A and group B, respectively. At 6 months, patients in Group A 25OHD3 level was 22⋅8 ± 3⋅80 and in Group B was 34⋅0 ± 1⋅85 ng/ml (P < 0⋅001). This preliminary study suggests that obese patients need higher dosage of vitamin D than the recommended dose. It is prudent that the dosage should be based on the BMI to maintain normal levels for a healthy musculoskeletal system.

Malnutrition among adolescents is often associated with inadequate dietary diversity (DD). We aimed to explore the prevalence of inadequate DD and its socio-economic determinants among adolescent girls and boys in Bangladesh. A cross-sectional survey was conducted during the 2018–19 round of national nutrition surveillance in Bangladesh. Univariate and multivariable logistic regression was performed to identify the determinants of inadequate DD among adolescent girls and boys separately. This population-based survey covered eighty-two rural, non-slum urban and slum clusters from all divisions of Bangladesh. A total of 4865 adolescent girls and 4907 adolescent boys were interviewed. The overall prevalence of inadequate DD was higher among girls (55⋅4 %) than the boys (50⋅6 %). Moreover, compared to boys, the prevalence of inadequate DD was higher among the girls for almost all socio-economic categories. Poor educational attainment, poor maternal education, female-headed household, household food insecurity and poor household wealth were associated with increased chances of having inadequate DD in both sexes. In conclusion, more than half of the Bangladeshi adolescent girls and boys consumed an inadequately diversified diet. The socio-economic determinants of inadequate DD should be addressed through context-specific multisectoral interventions.

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leading to acute respiratory distress syndrome (ARDS). Understanding the evolution of the virus, and immune-pathogenic processes are critical for designing future therapeutic interventions. In this review, we collate information on the structure, genome, viral life cycle, and adult and pediatric host immune responses in response to SARS-CoV-2. The immunological responses are a prototype of the developmental origins of health and disease (DOHaD) hypothesis to explain the socio-geographic differences impacting the severity and mortality rates in SARS-CoV-2 infections. The DOHaD hypothesis identifies the relevance of trained innate immunity, age groups, and geography for effective vaccinations. As COVID-19 vaccines are being rolled out, it may be pertinent to assess population-based immunological responses to understand the effectiveness and safety across different populations and age groups.

The World Health Organization set a target of a 15% relative reduction in the prevalence of insufficient physical activity (IPA) by 2025 among adolescents and adults globally. In Bangladesh, there are no national estimates of the prevalence of IPA among adolescents. The aim of this study was to estimate the prevalence of and risk factors associated with IPA among adolescent girls and boys. Data for 4865 adolescent girls and 4907 adolescent boys, collected as a part of a National Nutrition Surveillance in 2018–19, were analysed for this study. A modified version of the Global Physical Activity Questionnaire (GPAQ) was used to collect physical activity data. The World Health Organization recommended cut-off points were used to estimate the prevalence of IPA. Bivariate and multivariable logistic regression was performed to identify factors associated with IPA. Prevalences of IPA among adolescent girls and boys were 50.3% and 29.0%, respectively, and the prevalence was significantly higher among early adolescents (10–14 years) than late adolescents (15–19 years) among both boys and girls. The IPA prevalence was highest among adolescents living in non-slum urban areas (girls: 77.7%; boys: 64.1%). For both boys and girls, younger age, non-slum urban residence, higher paternal education and increased television viewing time were significantly associated with IPA. Additionally, residing in slums was significantly associated with IPA only among the boys. Higher maternal education was associated with IPA only among the girls. This study identified several modifiable risk factors associated with IPA among adolescent boys and girls in Bangladesh. These factors should be addressed through comprehensive public health interventions to promote physical activity among adolescent girls and boys.

Coronavirus disease 2019 (COVID-19) has rapidly spread globally, forcing countries to apply lockdowns and strict social distancing measures. The aim of this study was to assess eating habits and lifestyle behaviours among residents of the Middle East and North Africa (MENA) region during the lockdown. A cross-sectional study among adult residents of the MENA region was conducted using an online questionnaire designed on Google Forms during April 2020. A total of 2970 participants from eighteen countries participated in the present study. During the pandemic, over 30 % reported weight gain, 6·2 % consumed five or more meals per d compared with 2·2 % before the pandemic (P < 0·001) and 48·8 % did not consume fruits on a daily basis. Moreover, 39·1 % did not engage in physical activity, and over 35 % spent more than 5 h/d on screens. A significant association between the frequency of training during the pandemic and the reported change in weight was found (P < 0·001). A significantly higher percentage of participants reported physical and emotional exhaustion, irritability and tension either all the time or a large part of the time during the pandemic (P < 0·001). Although a high percentage of participants reported sleeping more hours per night during the pandemic, 63 % had sleep disturbances. The study highlights that the lockdown due to the COVID-19 pandemic caused a variety of lifestyle changes, physical inactivity and psychological problems among adults in the MENA region.

Deaths due to opioid overdose have reached unprecedented levels in Canada; over 12,800 opioid-related deaths occurred between January 2016 and March 2019, and overdose death rates increased by approximately 50% from 2016 to 2018.1 In 2016, Health Canada declared the opioid epidemic a national public health crisis,2 and life expectancy increases have halted in Canada for the first time in decades.3 Children are not exempt from this crisis, and the Chief Public Health Officer of Canada has recently prioritized the prevention of problematic substance use among Canadian youth.4

This article reports the establishment of an isolated, fully functional field intensive care unit (FICU) unit equipped with all necessary critical care facilities as a part of the national pre-emptive preparedness to treat an unexpected surge outbreak of coronavirus disease 2019 (COVID-19) patients in Bahrain. One floor of an existing car parking structure was converted into a 130-bed FICU set-up by the in-house project implementation team comprised of multidisciplinary departments. The setting was a military hospital in the Kingdom of Bahrain, and the car park was on the hospital premises. The FICU contained a 112-bed fully equipped ICU and an 18-bed step-down ICU, and was built in 7 d to cater to the intensive care of COVID-19 patients in Bahrain.