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1 results

  • Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings

  • Dominic Fannon, Lakshika Tennakoon, Alex Sumich, Seamus O'Ceallaigh, Victor Doku, Xavier Chitnis, Jennifer Lowe, William Soni, Tonmoy Sharma
  • Journal:
    The British Journal of Psychiatry / Volume 177 / Issue 4 / October 2000
    Published online by Cambridge University Press:
    02 January 2018, pp. 354-359
    Print publication:
    October 2000
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  • Background

    Third rather than lateral ventriculomegaly may be a more specific finding in psychosis. The relevance of ventricular abnormality remains unclear.

    Aims

    To investigate the developmental correlates of ventricular enlargement.

    Method

    Information on childhood development and magnetic resonance images in 1.5-mm contiguous sections were collected on 21 patients experiencing a first episode of psychosis.

    Results

    Patients (n=21) had significantly less whole brain volume and enlarged third and lateral ventricles compared to controls (n=25). Third ventricle (r=0.48, P < 0.03) and lateral ventricle (r=0.65, P < 0.01) volumes correlated with developmental score. Patients with developmental delay had significantly larger third and lateral ventricles than those without.

    Conclusions

    Enlargement of both third and lateral ventricles is found in first-episode psychosis and is related to developmental delay in childhood. Insult to periventricular areas is relevant to the neurobiology of the disease. These findings support the view that schizophrenia involves disturbance of neurodevelopmental processes in some patients.