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“Dis-stance” (Ent-fernung) isDasein’s spatiality as “bringing-near”: an entity’s “far-ness” (Ferne) is overcome or or abolished (ent-), and brought into the proximal ambit of Dasein’s coping engagement in the significant nexus that is its world
Neuzeit, a somewhat old-fashioned term for “modernity,” literally means “New Age.” Heidegger uses the term to contrast the stage of Western metaphysics that began “three centuries ago” (GA16:677/HR 330) with Greek antiquity and the Middle Ages. Modernity arrives at its completed or consummate form in the age of technology (see, e.g., GA50:149).
Dopaminergic imaging is an established biomarker for dementia with Lewy bodies, but its diagnostic accuracy at the mild cognitive impairment (MCI) stage remains uncertain.
To provide robust prospective evidence of the diagnostic accuracy of dopaminergic imaging at the MCI stage to either support or refute its inclusion as a biomarker for the diagnosis of MCI with Lewy bodies.
We conducted a prospective diagnostic accuracy study of baseline dopaminergic imaging with [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computerised tomography (123I-FP-CIT SPECT) in 144 patients with MCI. Images were rated as normal or abnormal by a panel of experts with access to striatal binding ratio results. Follow-up consensus diagnosis based on the presence of core features of Lewy body disease was used as the reference standard.
At latest assessment (mean 2 years) 61 patients had probable MCI with Lewy bodies, 26 possible MCI with Lewy bodies and 57 MCI due to Alzheimer's disease. The sensitivity of baseline FP-CIT visual rating for probable MCI with Lewy bodies was 66% (95% CI 52–77%), specificity 88% (76–95%) and accuracy 76% (68–84%), with positive likelihood ratio 5.3.
It is over five times as likely for an abnormal scan to be found in probable MCI with Lewy bodies than MCI due to Alzheimer's disease. Dopaminergic imaging appears to be useful at the MCI stage in cases where Lewy body disease is suspected clinically.
Novel commercially available software has enabled registration of both CT and MRI images to rapidly fuse with X-ray fluoroscopic imaging. We describe our initial experience performing cardiac catheterisations with the guidance of 3D imaging overlay using the VesselNavigator system (Philips Healthcare, Best, NL). A total of 33 patients with CHD were included in our study. Demographic, advanced imaging, and catheterisation data were collected between 1 December, 2016 and 31 January, 2019. We report successful use of this technology in both diagnostic and interventional cases such as placing stents and percutaneous valves, performing angioplasties, occlusion of collaterals, and guidance for lymphatic interventions. In addition, radiation exposure was markedly decreased when comparing our 10–15-year-old coarctation of the aorta stent angioplasty cohort to cases without the use of overlay technology and the most recently published national radiation dose benchmarks. No complications were encountered due to the application of overlay technology. 3D CT or MRI overlay for CHD intervention with rapid registration is feasible and aids decisions regarding access and planned angiographic angles. Operators found intraprocedural overlay fusion registration using placed vessel guidewires to be more accurate than attempts using bony structures.
Carbon-enhanced metal-poor stars are probes of the early universe, that teach us about metal-poor AGB stars and supernovae physics in the very first stars. We find a large fraction of CEMP-no stars with large absolute carbon abundance to be in binary systems. This may be an indication of binary interaction with ultra or extremely metal-poor AGB stars, curiously without enhancement in s-process elements.
We monitor a sample of CEMP-no stars using the CFHT and SALT telescopes to gain additional knowledge about the possible binarity of these stars. This information is valuable for each individual star, and additionally it could be used to further constrain their binary fraction. We find two new CEMP-no binaries and four additional CEMP-no stars that show some indication of radial velocity variations, resulting in a CEMP-no binary fraction of ~20%.
We discuss workers’ dignity in hierarchical organizations. First, we explain why a conflict exists between high-ranking individuals’ authority and low-ranking individuals’ dignity. Then, we ask whether there is any justification that reconciles hierarchical authority with the dignity of workers. We advance a communitarian justification for hierarchical authority, drawing upon Confucianism, which provides that workers can justifiably accept hierarchical authority when it enables a certain type of social functioning critical for the good life of workers and other involved parties. The Confucian communitarian perspective shows that promoting workers’ good life or well-being is an important condition for protecting their dignity.
In this article we investigate a philosophical problem for normative business ethics theory suggested by a phenomenon that contemporary psychologists call “bounded ethicality,” which can be identified with the putative fact that well-intentioned people, constrained by psychological limitations, make ethical choices inconsistent with their own ethical beliefs and commitments. When one combines the idea that bounded ethicality is pervasive with the idea that a person morally ought to do something only if she can, it raises a doubt about the practical relevance of the moral principles that business ethics theory prescribes. We call this doubt the Radical Behavioral Challenge. It consists in the idea that people cannot generally conform to the normative ethical principles that business ethics theorists prescribe, and that these principles are therefore practically irrelevant. We answer the Radical Behavioral Challenge and explore normative implications of our answer.
The carbon nanotube community swims in the sea of superlatives. Researchers expect mechanical performance to achieve two extremes, an ultrastrong fibre taking us into space, and a superlubricant saving energy otherwise lost as heat. We examine CNT fibres in the light of traditional yarn science and present an interpretation of properties which combines aspects of these two extremes of performance.
A spinetail devilray (Mobula japanica) was recorded for the first time in the western waters of Australia. The beach-stranded individual was observed in March 2013 on the southern coast of Western Australia (latitude 34.8811°S, longitude 118.4079°E). This is the southernmost record of this species in Australian waters. Previous Australian records of this species have been restricted to the east coast, where sightings have been within the latitudinal range of 14–33°S. The individual observed in Western Australia was a mature male, with a disc width of 257 cm. The occurrence coincided with the maximum recorded summer sea surface temperature (22.0°C) along the southern coast of Western Australia and an abnormally strong flow in the Leeuwin Current for that time of year.
The Craniofacial Biology Research Group in the School of Dentistry at The University of Adelaide is entering an exciting new phase of its studies of dental development and oral health in twins and their families. Studies of the teeth and faces of Australian twins have been continuing for nearly 30 years, with three major cohorts of twins recruited over that time, and currently we are working with twins aged 2 years old to adults. Cross-sectional data and records relating to teeth and faces of twins are available for around 300 pairs of teenage twins, as well as longitudinal data for 300 pairs of twins examined at three different stages of development, once with primary teeth, once at the mixed dentition stage, and then again when the permanent teeth had emerged. The third cohort of twins comprises over 600 pairs of twins recruited at around birth, together with other family members. The emphasis in this third group of twins has been to record the timing of emergence of the primary teeth and also to sample saliva and dental plaque to establish the timing of colonization of decay-forming bacteria in the mouth. Analyses have confirmed that genetic factors strongly influence variation in timing of primary tooth emergence. The research team is now beginning to carry out clinical examinations of the twins to see whether those who become colonized earlier with decay-forming bacteria develop dental decay at an earlier age. By making comparisons within and between monozygotic (MZ) and dizygotic (DZ) twin pairs and applying modern molecular approaches, we are now teasing out how genetic, epigenetic, and environmental factors interact to influence dental development and also oral health.
We argue that Confucianism makes a fundamental contribution to understanding why civility is necessary for a morally decent workplace. We begin by reviewing some limits that traditional moral theories face in analyzing issues of civility. We then seek to establish a Confucian alternative. We develop the Confucian idea that even in business, humans may be sacred when they observe rituals culturally determined to express particular ceremonial significance. We conclude that managers and workers should understand that there is a broad range of morally important rituals in organizational life and that managers should preserve and develop the intelligibility and integrity of many of these rituals.
Studies of twins carried out over the past 25 years by the Craniofacial Biology Research Group at the University of Adelaide have provided insights into the roles of genetic, environmental and epigenetic influences on human dento-facial growth and development. The aim of this paper is to review some of the main findings of these studies and to highlight the value of using different twin models, including the monozygotic (MZ) co-twin design. We also introduce the concept of ‘dental phenomics’ whereby modern 2D and 3D imaging systems are now enabling biologically-meaningful, dental phenotypes to be quantified in order to provide detailed descriptions of the size and shape of teeth. We propose that developments in the field of ‘dental phenomics’, with linking of the data generated to large-scale genome sequencing approaches, should enable us to further unravel the mysteries of how genetic, environmental and epigenetic factors interact to produce the extensive range of morphological variations evident within the human dentition and face.
The Craniofacial Biology Research Group at the University of Adelaide has been involved in studies of the teeth and faces of twins for over 25 years (Townsend et al., 2006). Our main aim is to clarify the roles of genetic, environmental and epigenetic influences on human dento-facial growth and development. Three cohorts of twins have been recruited to enable different objectives and specific hypotheses to be addressed.