The human large intestinal microbiota thrives on dietary carbohydrates that are converted to a range of fermentation products. Short-chain fatty acids (acetate, propionate and butyrate) are the dominant fermentation acids that accumulate to high concentrations in the colon and they have health-promoting effects on the host. Although many gut microbes can also produce lactate, it usually does not accumulate in the healthy gut lumen. This appears largely to be due to the presence of a relatively small number of gut microbes that can utilise lactate and convert it to propionate, butyrate or acetate. There is increasing evidence that these microbes play important roles in maintaining a healthy gut environment. In this review, we will provide an overview of the different microbes involved in lactate metabolism within the gut microbiota, including biochemical pathways utilised and their underlying energetics, as well as regulation of the corresponding genes. We will further discuss the potential consequences of perturbation of the microbiota leading to lactate accumulation in the gut and associated disease states and how lactate-utilising bacteria may be employed to treat such diseases.

Metabolites produced by microbial fermentation in the human intestine, especially short-chain fatty acids (SCFAs), are known to play important roles in colonic and systemic health. Our aim here was to advance our understanding of how and why their concentrations and proportions vary between individuals. We have analysed faecal concentrations of microbial fermentation acids from 10 human volunteer studies, involving 163 subjects, conducted at the Rowett Institute, Aberdeen, UK over a 7-year period. In baseline samples, the % butyrate was significantly higher, whilst % iso-butyrate and % iso-valerate were significantly lower, with increasing total SCFA concentration. The decreasing proportions of iso-butyrate and iso-valerate, derived from amino acid fermentation, suggest that fibre intake was mainly responsible for increased SCFA concentrations. We propose that the increase in % butyrate among faecal SCFA is largely driven by a decrease in colonic pH resulting from higher SCFA concentrations. Consistent with this, both total SCFA and % butyrate increased significantly with decreasing pH across five studies for which faecal pH measurements were available. Colonic pH influences butyrate production through altering the stoichiometry of butyrate formation by butyrate-producing species, resulting in increased acetate uptake and butyrate formation, and facilitating increased relative abundance of butyrate-producing species (notably Roseburia and Eubacterium rectale).

Stars with masses between ∼0.7 and 8 M⊙ end their lives as Planetary Nebulae (PNe). With the MegaCam at CFHT, we have carried out a survey of the central 16 sq. degrees of Andromeda (M31) reaching the outer disk and halo, using a narrow-band [OIII]5007 and a broad-band g filter. This survey extends previous PN samples both in uniform area coverage and depth. We identify ∼4000 PNe in M31, of which ∼3000 are new discoveries. We detect PNe down to ∼6 mag below the bright cut-off of the PN luminosity function (PNLF), ∼2 mag deeper than in previous works. We detect a steep rise in the number of PNe at ∼4.5 mag fainter than the bright cut-off. It persists as we go radially outwards and is steeper than that seen in the Magellanic clouds. We explore possible reasons for this rise, which give insights into the stellar population of M31.

Deflection missions to near-Earth asteroids will encounter non-negligible uncertainties in the physical and orbital parameters of the target object. In order to reliably assess future impact threat mitigation operations such uncertainties have to be quantified and incorporated into the mission design. The implementation of deflection demonstration missions offers the great opportunity to test our current understanding of deflection relevant uncertainties and their consequences, e.g., regarding kinetic impacts on asteroid surfaces. In this contribution, we discuss the role of uncertainties in the NEOTωIST asteroid deflection demonstration concept, a low-cost kinetic impactor design elaborated in the framework of the NEOShield project. The aim of NEOTωIST is to change the spin state of a known and well characterized near-Earth object, in this case the asteroid (25143) Itokawa. Fast events such as the production of the impact crater and ejecta are studied via cube-sat chasers and a flyby vehicle. Long term changes, for instance, in the asteroid's spin and orbit, can be assessed using ground based observations. We find that such a mission can indeed provide valuable constraints on mitigation relevant parameters. Furthermore, the here proposed kinetic impact scenarios can be implemented within the next two decades without threatening Earth's safety.

The Craniofacial Biology Research Group in the School of Dentistry at The University of Adelaide is entering an exciting new phase of its studies of dental development and oral health in twins and their families. Studies of the teeth and faces of Australian twins have been continuing for nearly 30 years, with three major cohorts of twins recruited over that time, and currently we are working with twins aged 2 years old to adults. Cross-sectional data and records relating to teeth and faces of twins are available for around 300 pairs of teenage twins, as well as longitudinal data for 300 pairs of twins examined at three different stages of development, once with primary teeth, once at the mixed dentition stage, and then again when the permanent teeth had emerged. The third cohort of twins comprises over 600 pairs of twins recruited at around birth, together with other family members. The emphasis in this third group of twins has been to record the timing of emergence of the primary teeth and also to sample saliva and dental plaque to establish the timing of colonization of decay-forming bacteria in the mouth. Analyses have confirmed that genetic factors strongly influence variation in timing of primary tooth emergence. The research team is now beginning to carry out clinical examinations of the twins to see whether those who become colonized earlier with decay-forming bacteria develop dental decay at an earlier age. By making comparisons within and between monozygotic (MZ) and dizygotic (DZ) twin pairs and applying modern molecular approaches, we are now teasing out how genetic, epigenetic, and environmental factors interact to influence dental development and also oral health.

We surveyed Ronald McDonald Houses (RMHs) to assess infection prevention and control (IPC) practices. A diverse patient population is served by RMH. Most sites have locally written IPC guidelines, and consultation resources vary, increasing the potential for inconsistent IPC practices. RMH would benefit from a standardized IPC guideline.

Infect Control Hosp Epidemiol 2012;33(3):299-301

Following its meeting in May, 2010, the IAU Executive Committee requested that a Working Group on NEOs within Div. III be re-activated and carry out the following activities:

1. a) investigate and formulate requirements for an international ground- and/or space-based NEO survey, to detect, track and characterize (optical/IR, radar) 90% of all NEOs with D >40 m and to establish as such a permanent International NEO Early Warning System; to submit to the President, Vice-President and OC of Division III by March 31, 2011, a progress report and by March 31, 2012, a final report on this matter, to be forwarded to the President and General Secretary of the IAU;

2. b) assemble a SOC in order to write and submit to the IAU Assistant General Secretary before December 1, 2010, a proposal for a GA IAU Symposium or a GA Special Session, to be held during the IAU XXVIII General Assembly, August 20-31, 2012 in Beijing, on theoretical and observational aspects of NEO research in general, and on requirements and other aspects of a permanent International NEO Early Warning System in particular;

3. c) prepare and submit to the IAU General Secretary by January 31, 2012, a Resolution for consideration by the IAU XXVIII General Assembly in Beijing, August 2012, asking for international action and support to establish an International NEO Early Warning System; such a Resolution, if accepted by the IAU XXVIII General Assembly, to be addressed to the IAU National Members, to the United Nations Committee on the Peaceful Uses of Outer Space (UN-COPUOS), and to the International Council for Science (ICSU).

We describe 22 patients from a multistate outbreak of Serraría marcescens bacteremia that was linked to contaminated prefilled syringes of heparin and saline supplied by 1 manufacturer. Contents of unused syringes were cultured in pools samples from 25 (5.3%) of 472 syringes grew S. marcescens. Despite good clinical outcomes overall, patients had substantial morbidity.