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9 results

  • Breastfeeding does not protect against the development of carditis in children with acute rheumatic fever
  • Funda Gurbuz, Nejla Canbulat Sahiner, Emin Unal, Ahmet Seyfeddin Gurbuz, Tamer Baysal
  • Journal: Cardiology in the Young , First View
  • Published online by Cambridge University Press: 20 June 2022, pp. 1-5
  • View abstract
    Introduction:

    Acute rheumatic fever is an autoimmune disease that develops due to streptococcal infection. The positive effect of breastfeeding on the development of the child’s immune system is well documented. In this study, we aimed to investigate the effect of breast milk intake period on the development of carditis.

    Materials and methods:

    Patients (n: 182) who were diagnosed with acute rheumatic fever between 2010 and 2019 were enrolled in the study. The patients were divided into groups according to carditis development. The demographic, socio-economic, and breastfeeding data were compared between groups.

    Results:

    The mean age of the patients was 10.5 ± 3.4, and 43.4 % (n: 79) of them were female. Independent predictors of the development of carditis in the first acute rheumatic fever episode were the number of children at home (OR: 1.773, CI 95%: 1.105, 2.845; p: 0.018) and breast milk intake less than 6 months (OR: 0.404, CI 95%: 0.174, 0.934; p: 0.034). Independent predictors of the development of carditis in any of the acute rheumatic fever episodes were the number of children at home (OR: 1.858, CI 95%: 1.100, 3.137; p: 0.021) and female gender (OR: 3.504, CI 95%: 1.227, 10.008; p: 0.019). The only independently predictor of the development of chorea during acute rheumatic fever was female gender (OR: 3.801, CI 95%: 1.463, 9.874; p: 0.006).

    Conclusion:

    Although the occurrence of carditis is less common during the first acute rheumatic fever attack in patients with breast milk intake less than six months, this advantage is lost in recurrent attacks. This study showed that breast milk does not have a negative effect on acute rheumatic fever carditis.

  • Electrocardiographic data of children with type 1 diabetes mellitus
  • Mehmet Türe, Alper Akın, Edip Unal, Ahmet Kan, Suat Savaş
  • Journal: Cardiology in the Young / Volume 32 / Issue 1 / January 2022
  • Published online by Cambridge University Press: 02 November 2021, pp. 106-110
  • View abstract
    Background:

    Adult patients diagnosed with type 1 diabetes mellitus are at risk for ventricular arrhythmias and sudden cardiac death.

    Aim:

    The objective of our study is to evaluate the electrocardiographic data of children diagnosed with type 1 diabetes mellitus and to determine the possibility of arrhythmia in order to prevent sudden death.

    Methods:

    Electrocardiographic data of 60 patients diagnosed with type 1 diabetes mellitus and 86 controls, who were compatible with the patient group in terms of age and gender, were compared.

    Results:

    The duration of diabetes in our patients with type 1 diabetes mellitus was 5.23 ± 1.76 years, and the haemoglobin A1c levels were 9.63% ± 1.75%. The heart rate, QRS, QT maximum, QT dispersion, QTc minimum, QTc maximum, QTc dispersion, Tp-e maximum, Tp-e maximum/QTc maximum and the JTc were significantly higher compared to the control group. There was no significant correlation between the duration of type 1 diabetes mellitus and HbA1c levels and the electrocardiographic data.

    Conclusion:

    We attributed the lack of a significant correlation between the duration of type 1 diabetes mellitus and the haemoglobin A1c levels and the electrocardiographic data to the fact that the duration of diabetes was short, since our patients were children. We believe that patients with type 1 diabetes mellitus should be followed up closely in terms of sudden death, as they have electrocardiographic changes that may cause arrhythmias compared to the control group. However, more studies with longer follow-up periods are necessary to support our data.

  • Malonyl coenzyme A decarboxylase deficiency with a novel mutation
  • Cigdem S. Kasapkara, Burcu Civelek Ürey, Ahmet C. Ceylan, Özlem Ünal Uzun, Ibrahim İ. Çetin
  • Journal: Cardiology in the Young / Volume 31 / Issue 9 / September 2021
  • Published online by Cambridge University Press: 22 March 2021, pp. 1535-1537
  • View abstract

    Malonyl-CoA, a product of acetyl-CoA carboxylase is a metabolic intermediate in lipogenic tissues that include liver and adipose tissue, where it is involved in the de novo fatty acid synthesis and elongation. Malonyl-CoA decarboxylase (MLYCD, E.C.4.1.1.9), a 55-kDa enzyme catalyses the conversion of malonyl-CoA to acetyl-CoA and carbon dioxide, thus providing a route for disposal of malonyl-CoA from mitochondria and peroxisomes, whereas in the cytosol, the malonyl-CoA pool is regulated by the balance of MLYCD and acetyl-CoA carboxylase activities. So far, 34 cases with different MLYCD gene defects comprising point mutations, stop codons, and frameshift mutations have been reported in the literature. Here, we describe the follow-up of a patient affected by malonic aciduria upon neonatal onset. Molecular analysis showed novel homozygous mutations in the MLYCD gene. Our findings expand the number of reported cases and add a novel variant to the repertoire of MLYCD mutations.

  • High-resolution signal processing techniques for through-the-wall imaging radar systems
  • Ahmet Serdar Turk, Pinar Ozkan-Bakbak, Lutfiye Durak-Ata, Melek Orhan, Mehmet Unal
  • Journal: International Journal of Microwave and Wireless Technologies / Volume 8 / Issue 6 / September 2016
  • Published online by Cambridge University Press: 29 April 2016, pp. 855-863
  • View abstract

    Through-the-Wall Imaging is an ever-expanding area in which processing time, scanning time, vertical, and horizontal resolutions have been tried to improve. In this study, several methods are investigated to obtain efficient reconstruction of through-the-wall imaging radar signals with high resolution. Microwave radar signals, which are produced in YTU Microwave Laboratory, are processed by compressive sensing (CS). B and C scanned reflection data samples collected between 1 and 7 GHz frequency band are taken randomly at 1/4, 1/2 of whole amount and reconstructed by CS method. Considering the signal structure, 10 and 20 compressible Fourier coefficients are taken through CS to analyze the difference between them. In addition, we applied synthetic aperture radar (SAR) processing, also combined with SAR-Multiple Signal Classification over raw data. Experimental performance results are given and shown in the figures with high quality.

  • A Hittite treaty tablet from Oylum Höyük in southeastern Turkey and the location of Ḫaššu(wa)
  • Ahmet Ünal
  • Journal: Anatolian Studies / Volume 65 / 2015
  • Published online by Cambridge University Press: 06 July 2015, pp. 19-34
  • Print publication: 2015
  • View abstract

    In the summer of 2012 Oylum Höyük yielded its first Hittite cuneiform tablet and thus joined five other Hittite tabletyielding sites in southeastern Anatolia and northern Syria. The tablet was probably removed from a nearby Hittite imperial-period monumental building, which seems to have been the Hittites’ administrative centre at Oylum, and incorporated into Iron Age debris. The wording of the text, in its preserved parts, shares traits with Hittite state treaties. It also has striking similarities with Hittite instruction texts, due to the generic affinities between these two genres. However, on the basis of the overall structure of the Oylum tablet and, most significantly, the inclusion of a list of oath gods at the end of the text, it is proposed that we are dealing here with a treaty. This article clarifies the genre and comprehensible context of the tablet, provides a transliteration and, as far as it is possible, a translation of the text, provides some philological comments and ends with the suggestion that the ancient name of Oylum Höyük was Ḫaššu(wa).

  • Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?
  • Feridun Bulbul, Osman Virit, Gokay Alpak, Ahmet Unal, Mahmut Bulut, Mehmet Cemal Kaya, Abdurrahman Altindag, Hakim Celik, Haluk A. Savas
  • Journal: Acta Neuropsychiatrica / Volume 26 / Issue 2 / April 2014
  • Published online by Cambridge University Press: 09 September 2013, pp. 120-124
  • View abstract
    Objective

    Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism.

    Methods

    Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS.

    Results

    TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups.

    Conclusion

    Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.

  • The Textual Illustration of the “Jester Scene” on the Sculptures of Alaca Höyük*
  • Ahmet Ünal
  • Journal: Anatolian Studies / Volume 44 / December 1994
  • Published online by Cambridge University Press: 23 December 2013, pp. 207-218
  • Print publication: December 1994
  • View extract

    The following article has to be conceived as one of my responses to a long standing and enigmatic question-mark which I have been carrying incessantly in mind since my first acquaintance with cuneiform writing and archaeology: Are there interactive implications between archaeological record and textual context in Hittite Anatolia at all? One might promptly and spontaneously expect that as a principle there must have been close relations between both sorts of data, since, first of all, they are mental and material products of the same people. Why are, then, the results gained from comparisons of archaeological and philological material disappearingly feeble considering that Hittitology is in a very lucky position in being supplied abundantly by both sorts of material? The temporary results gained from the comparative studies by other scholars as well as by myself were often disappointingly meagre. This is one of the reasons why I have frequently pointed out in a pessimistic way inconsistencies between archaeological objects and information supplied by the written sources in Hittite culture.