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This chapter addresses key questions about the basis of cancer susceptibility in African people, as well as the uniqueness of the population genetics and genotype–phenotype relationship that resulted during social transition. Social transition encompasses the change of lifestyle from a rural subsistence one into an urban market-oriented, technology dependent, and predominantly sedentary mode of life, as well as changes that occur in the population genetics as a result of changes from ethnically defined structured populations into panmictic populations of an urban nature, as currently seen in megacities. Although humans passed through several periods of transition in history, the current one is the most profound.
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