To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Stéphane Viville, Laboratoire de Génétique Médicale de Strasbourg and Laboratoire de diagnostic génétique, Strasbourg,Karen D. Sermon, Reproduction and Genetics Research Group, Vrije Universiteit Brussel
Since the birth of the first baby via in vitro fertilization (IVF) in 1978, there has been concern about the safety of IVF and other assisted reproduction technology (ART) procedures for the health of ART-conceived children. Data show that ART singletons are at increased risk for adverse perinatal outcomes such as low birthweight and being small for gestational age, and congenital malformations . The biological mechanism behind these risks is mainly unresolved. Since the publication of a few case reports on the incidence of rare imprinting disorders such as Angelman and Beckwith–Wiedemann syndromes in ART-conceived children, epigenetic deregulation has gained increasing attention as a possible common cause for the adverse outcomes. This led to an expansion of ART literature on epigenetic effects. In this chapter, I focus on the current knowledge of epigenetic disturbances in humans, reported after ART in general and in relation to specific ART components, and the difficulties encountered in these kinds of studies. When needed, animal studies will also be mentioned. The subfertility of the population as a possible cause for the epigenetic deregulation is also taken into consideration. Finally, I discuss whether epigenetic effects can be related to the reported health outcome in ART children and if these possible derangements can affect their health at adult age.