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1 results

  • Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori

  • FEDERICA SANDRELLI, SILVIA CAPPELLOZZA, CLARA BENNA, ALESSIO SAVIANE, ANTONIO MASTELLA, GABRIELLA M. MAZZOTTA, STEPHANE MOREAU, MIRKO PEGORARO, ALBERTO PICCIN, MAURO A. ZORDAN, LUCIANO CAPPELLOZZA, CHARALAMBOS P. KYRIACOU, RODOLFO COSTA
  • Journal:
    Genetical Research / Volume 89 / Issue 2 / April 2007
    Published online by Cambridge University Press:
    02 August 2007, pp. 73-84
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  • The lepidopteran Bombyx mori is an insect of considerable scientific and economic importance. Recently, the B. mori circadian clock gene period has been molecularly characterized. We have transformed a B. mori strain with a construct encoding a period double-strand RNA in order to knock-down period gene expression. We observe that this post-transcriptional silencing produces a small but detectable disruption in the egg-hatching rhythm, as well as a reduction in egg-to-adult developmental time, without altering silk production parameters. Thus we show that both circadian and non-circadian phenotypes can be altered by changing per expression, and, at a practical level, these results suggest that per knock-down may provide a suitable strategy for improving the efficiency of rearing, without affecting silk productivity.