The social cost of greenhouse gases is important in many regulatory impact analyses. However, calculations of the social cost of greenhouse gases are highly complex and periodically revisited. We offer seven recommendations to improve current estimates. These include recommendations to use both country-level and global measures of the social cost of greenhouse gases, to use country-specific values for monetizing climate damages, to represent uncertainties by reporting distributions instead of using only central values, and to conduct a temporal distributional analysis that shows the magnitudes of climate damages across generations. We also provide recommendations for the discount rates that should be used when estimating the social cost of greenhouse gases, and the appropriate discount rates for regulatory impact analyses that include the social cost of greenhouse gases.

Only 6 to 8 % of the UK adults meet the daily recommendation for dietary fibre. Fava bean processing lead to vast amounts of high-fibre by-products such as hulls. Bean hull fortified bread was formulated to increase and diversify dietary fibre while reducing waste. This study assessed the bean hull: suitability as a source of dietary fibre; the systemic and microbial metabolism of its components and postprandial events following bean hull bread rolls. Nine healthy participants (53·9 ± 16·7 years) were recruited for a randomised controlled crossover study attending two 3 days intervention sessions, involving the consumption of two bread rolls per day (control or bean hull rolls). Blood and faecal samples were collected before and after each session and analysed for systemic and microbial metabolites of bread roll components using targeted LC-MS/MS and GC analysis. Satiety, gut hormones, glucose, insulin and gastric emptying biomarkers were also measured. Two bean hull rolls provided over 85 % of the daily recommendation for dietary fibre; but despite being a rich source of plant metabolites (P = 0·04 v. control bread), these had poor systemic bioavailability. Consumption of bean hull rolls for 3 days significantly increased plasma concentration of indole-3-propionic acid (P = 0·009) and decreased faecal concentration of putrescine (P = 0·035) and deoxycholic acid (P = 0·046). However, it had no effect on postprandial plasma gut hormones, bacterial composition and faecal short chain fatty acids amount. Therefore, bean hulls require further processing to improve their bioactives systemic availability and fibre fermentation.

Situated within the public will and political will framework, this paper explores frames to address the social issue of gender pay inequity. Specifically, the authors examine whether demographic characteristics affect perceived acceptability of different frames describing gender pay inequity and perceptions of this social issue. First, the authors identified 26 terms used to discuss gender pay inequity; this list was narrowed to 12, representing four categories. Next, the authors solicited sentiment reactions to those frames and perceptions of gender pay inequity. Taken together, the results indicated that although respondents had consistently positive reactions to the frames fair pay, equal pay, and pay fairness, perceptions varied across demographic groups. The biggest effects were consistently for political party-related variables. One frame, strategic compensation practices, emerged as a value-neutral frame that could potentially be used to reframe the issue and re-engage business and political stakeholders who do not perceive gender pay inequity as problematic.

We explore the motion of an axisymmetric gravity current in an anisotropic porous medium in which the horizontal permeability is larger than the vertical permeability. It is well known that the classical axisymmetric gravity current supplied by a constant point source of fluid has an unphysical singularity near the origin. We address this by considering a pressure-dominated region near the origin which allows for vertical flow from the source, such that the current remains of finite depth, whilst beyond this region the flow is gravity dominated. At early times the inner pressure-driven region controls the spreading of the current, but at late times the inner region occupies a progressively smaller fraction of the current such that the radius increases as ${\sim }t^{3/7}$, while the depth near the origin increases approximately as ${\sim }t^{1/7}$. The presence of anisotropy highlights this phenomenon, since the vertical permeability maintains an effect on the flow at late times through the pressure-driven flow near the origin. Using these results we provide some quantitative insights into the dominant dynamics which controls CO$_2$ migration through permeable aquifers, as occurs in the context of carbon capture and storage.

A general obligation to make aggregate research results available to participants has been widely supported in the bioethics literature. However, dementia research presents several challenges to this perspective, particularly because of the fear associated with developing dementia. The authors argue that considerations of respect for persons, beneficence, and justice fail to justify an obligation to make aggregate research results available to participants in dementia research. Nevertheless, there are positive reasons in favor of making aggregate research results available; when the decision is made to do so, it is critical that a clear strategy for communicating results is developed, including what support will be provided to participants receiving aggregate research results.

Metabolites produced by microbial fermentation in the human intestine, especially short-chain fatty acids (SCFAs), are known to play important roles in colonic and systemic health. Our aim here was to advance our understanding of how and why their concentrations and proportions vary between individuals. We have analysed faecal concentrations of microbial fermentation acids from 10 human volunteer studies, involving 163 subjects, conducted at the Rowett Institute, Aberdeen, UK over a 7-year period. In baseline samples, the % butyrate was significantly higher, whilst % iso-butyrate and % iso-valerate were significantly lower, with increasing total SCFA concentration. The decreasing proportions of iso-butyrate and iso-valerate, derived from amino acid fermentation, suggest that fibre intake was mainly responsible for increased SCFA concentrations. We propose that the increase in % butyrate among faecal SCFA is largely driven by a decrease in colonic pH resulting from higher SCFA concentrations. Consistent with this, both total SCFA and % butyrate increased significantly with decreasing pH across five studies for which faecal pH measurements were available. Colonic pH influences butyrate production through altering the stoichiometry of butyrate formation by butyrate-producing species, resulting in increased acetate uptake and butyrate formation, and facilitating increased relative abundance of butyrate-producing species (notably Roseburia and Eubacterium rectale).

The critical period for weed control (CPWC) adds value to integrated weed management by identifying the period during which weeds need to be controlled to avoid yield losses exceeding a defined threshold. However, the traditional application of the CPWC does not identify the timing of control needed for weeds that emerge late in the critical period. In this study, CPWC models were developed from field data in high-yielding cotton crops during three summer seasons from 2005 to 2008, using the mimic weed, common sunflower, at densities of two to 20 plants per square meter. Common sunflower plants were introduced at up to 450 growing degree days (GDD) after crop planting and removed at successive 200 GDD intervals after introduction. The CPWC models were described using extended Gompertz and logistic functions that included weed density, time of weed introduction, and time of weed removal (logistic function only) in the relationships. The resulting models defined the CPWC for late-emerging weeds, identifying a period after weed emergence before weed control was required to prevent yield loss exceeding the yield-loss threshold. When weeds emerged in sufficient numbers toward the end of the critical period, the model predicted that crop yield loss resulting from competition by these weeds would not exceed the yield-loss threshold until well after the end of the CPWC. These findings support the traditional practice of ensuring weeds are controlled before crop canopy closure, with later weed control inputs used as required.

Recent X-ray observations by Jiang et al. have identified an active galactic nucleus (AGN) in the bulgeless spiral galaxy NGC 3319, located just $14.3\pm 1.1$ Mpc away, and suggest the presence of an intermediate-mass black hole (IMBH; $10^2\leq M_\bullet/\textrm{M}_{\odot}\leq 10^5$ ) if the Eddington ratios are as high as 3 to $3\times10^{-3}$ . In an effort to refine the black hole mass for this (currently) rare class of object, we have explored multiple black hole mass scaling relations, such as those involving the (not previously used) velocity dispersion, logarithmic spiral arm pitch angle, total galaxy stellar mass, nuclear star cluster mass, rotational velocity, and colour of NGC 3319, to obtain 10 mass estimates, of differing accuracy. We have calculated a mass of $3.14_{-2.20}^{+7.02}\times10^4\,\textrm{M}_\odot$ , with a confidence of 84% that it is $\leq $ $10^5\,\textrm{M}_\odot$ , based on the combined probability density function from seven of these individual estimates. Our conservative approach excluded two black hole mass estimates (via the nuclear star cluster mass and the fundamental plane of black hole activity—which only applies to black holes with low accretion rates) that were upper limits of ${\sim}10^5\,{\textrm M}_{\odot}$ , and it did not use the $M_\bullet$ – $L_{\textrm 2-10\,\textrm{keV}}$ relation’s prediction of $\sim$ $10^5\,{\textrm M}_{\odot}$ . This target provides an exceptional opportunity to study an IMBH in AGN mode and advance our demographic knowledge of black holes. Furthermore, we introduce our novel method of meta-analysis as a beneficial technique for identifying new IMBH candidates by quantifying the probability that a galaxy possesses an IMBH.

The Subglacial Antarctic Lakes Scientific Access (SALSA) Project accessed Mercer Subglacial Lake using environmentally clean hot-water drilling to examine interactions among ice, water, sediment, rock, microbes and carbon reservoirs within the lake water column and underlying sediments. A ~0.4 m diameter borehole was melted through 1087 m of ice and maintained over ~10 days, allowing observation of ice properties and collection of water and sediment with various tools. Over this period, SALSA collected: 60 L of lake water and 10 L of deep borehole water; microbes >0.2 μm in diameter from in situ filtration of ~100 L of lake water; 10 multicores 0.32–0.49 m long; 1.0 and 1.76 m long gravity cores; three conductivity–temperature–depth profiles of borehole and lake water; five discrete depth current meter measurements in the lake and images of ice, the lake water–ice interface and lake sediments. Temperature and conductivity data showed the hydrodynamic character of water mixing between the borehole and lake after entry. Models simulating melting of the ~6 m thick basal accreted ice layer imply that debris fall-out through the ~15 m water column to the lake sediments from borehole melting had little effect on the stratigraphy of surficial sediment cores.

Throughout the Ediacaran Period, variable water-column redox conditions persisted along productive ocean margins due to a complex interplay between nutrient supply and oceanographic restriction. These changing conditions are considered to have influenced early faunal evolution, with marine anoxia potentially inhibiting the development of the ecological niches necessary for aerobic life forms. To understand this link between oxygenation and evolution, the combined geochemical and palaeontological study of marine sediments is preferable. Located in the Yangtze Gorges region of southern China, lagoonal black shales at Miaohe preserve alga and putative metazoans, including Eoandromeda, a candidate total-group ctenophore, thereby providing one example of where integrated study is possible. We present a multi-proxy investigation into water-column redox variability during deposition of these shales (c. 560–551 Ma). For this interval, reactive iron partitioning indicates persistent water-column anoxia, while trace metal enrichments and other geochemical data suggest temporal fluctuations between ferruginous, euxinic and rare suboxic conditions. Although trace metal and total organic carbon values imply extensive basin restriction, sustained trace metal enrichment and δ15Nsed data indicate periodic access to open-ocean inventories across a shallow-marine sill. Lastly, δ13Corg values of between −35‰ and −40‰ allow at least partial correlation of the shales at Miaohe with Member IV of the Doushantuo Formation. This study provides evidence for fluctuating redox conditions in the lagoonal area of the Yangtze platform during late Ediacaran time. If these low-oxygen environments were regionally characteristic, then the restriction of aerobic fauna to isolated environments can be inferred.