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Addictive and psychiatric disorders are a significant barrier to retention in medical care leading to worse outcomes. As part of an HIV care expansion project, the H-STAR intervention was designed to treat substance use and psychiatric disorders for minority patients receiving co-located HIV medical care.
The intervention aim was to increase access to treatment for substance abuse and psychiatric disorders in minority HIV+ patients and reduce substance use.
The H-STAR primary objective was to offer substance and psychiatric evaluation and treatment with an integrated treatment model.
All participants in H-STAR underwent substance abuse screening and evaluation, using DSM-IV-TR criteria. Substance use was measured on the Government Performance Reports Act (GPRA) form at baseline and 6 months. Intensive outpatient treatment (IOP) using the Matrix Model as the behavioral intervention was available to all patients. All patients were offered and scheduled psychiatric evaluation and treatment with an onsite psychiatrist.
Of 123 enrolled persons with both baseline and 6 month GPRAs, the prevalence of substance abuse/dependence disorders were as follows: Alcohol: 32 (24.2%); Opiate: 54 (43.9%); Cocaine: 47(38.2%); and Marijuana: 26(21.1%). Thirty (22.1%) completed IOP. At 6 month follow-up there was statistically significant reduced use of alcohol, heroin and cocaine. Of 136 enrolled participants, seventy-five (55.1%) had psychiatric evaluations; 53 (70.7%) received medication management.
There was a significant reduction in all substance use; cocaine use remained the most prevalent. Despite open access to psychiatric evaluation, not all patients completed evaluation in spite of multiple attempts to reschedule.
Exposure to early life adversity (ELA) has been identified as a major risk factor in the development of major depressive disorder (MDD). It is hypothesized that a mediating mechanism may be environmentally induced alterations in gene function. In our REDEEM (Research in depression: endocrinology, epigenetics and neuroimaging) project we are examining possible epigenetic difference in some previously investigated target genes relevant to depression. To this end, methylation of the following genes were measured: NR3C1 (HPA axis), SLC6A4 (serotonin neurotransmitter function), and CD3ɛ (T cell receptor gene). We also looked at possible trans-generational transmission of epigenetic markers in a mother-baby sample.
DNA was isolated from depressed patients and controls and babies and a portion of the above genes, encompassing our regions of interest, were amplified by PCR. Percentage methylation levels were measured by pyrosequencing. mRNA was also measured for some gene products to see if function was related to methylation. HPA axis function was measured with serial saliva samples throughout the day.
to date: Methylation was increased in the CD3ɛ promoter in depressed subjects relative to controls. In the total group, those exposed to ELA had significantly increased methylation at this site. Levels of CD3ɛ mRNA levels were inversely related to methylation. There were some relationships between maternal ELA and baby methylation at the sites examined.
Consistent with an allostatic model of ELA damage, our findings suggest an alteration in epigenetic function in acquired immunity and the HPA axis, mediated by ELA. Findings will be discussed.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
Major depressive disorder (MDD) is a common psychiatric condition, affecting up to 350 million people worldwide. Its pathogenesis seems to involve dysregulation of the hypothalamic-pituitary (HPA) axis and inflammation as key elements of the condition. Stressful life events and in particular early life adversity seem to play an important role as risk factors for MDD. Epigenetic, which has been found to impact in the transcription of genes, seem to be associated with brain structure and function. Aim of the research was to provide an overview about neuroimaging (epi)-genetics in MDD.
Functional MRI, epigenetic and genetic information was obtained in a cohort of patients with MDD and healthy controls. Associations between, early life adversity, methylation of FKBP5 and SLC6A4, genetic variants and brain function and connectivity have been analysed.
Higher methylation of SLC6A4 gene was associated with higher BOLD response during emotion processing and lower BOLD response during higher order cognitive processes. Healthy participants with higher SLC6A4 methylation involved prefrontal cortical regions to a greater extent than the participants with lower SLC6A4 methylation, when trying to switch attention away from negative emotional stimuli (Frodl et al., 2015). Moreover, FKBP5 methylation was association with HPA axis functioning and amygdala brain function in patients with MDD. FKBP5 methylation also was related to grey matter volume.
Our study provides further support to the hypothesis that DNA methylation plays a role. Particular peripheral DNA methylation states of MDD candidate genes are associated with brain function during emotion processing in patients with MDD.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
This article has three sections, each of which deals with an Executive Order. The first section, “Office of Information and Regulatory Affairs (OIRA) Past,” emphasizes the critical role that Executive Orders played in the formation of OIRA. More specifically, OIRA owes its initial existence to the establishment of a centralized regulatory review system, the Quality of Life Review, which initiated Office of Management and Budget (OMB) review of environmental regulations through the issuance of a directive from OMB. Every subsequent President expanded OMBs powers through the issuance of Executive Orders which culminated in the Iconic Executive Order 12291. The section concludes with the recommendation that a select class of Executive Orders, and OMB Directives, be designated as “Iconic” by the National Archivist in consultation with the OIRA, and then given substantial deference by incoming Administrations. The second section, “OIRA Present,” describes an Executive Order issued during the Kennedy Administration which remains in effect but was promulgated prior to the establishment of OIRA and therefore recommends that a new Executive Order be issued which gives OIRA specific authority to participate in the conduct of interagency reviews of Executive Orders. The third section, “OIRA Future,” describes an Executive Order which implements a regulatory budget (RB) and institutionalizes a mechanism for controlling the size of the administrative state. This final section of the article recommends that the aforementioned Executive Order be reviewed and modified based upon the outcome of a request for public comments, and rules with demonstrated positive net benefits should no longer be accorded an automatic entitlement for issuance as a final rule absent their inclusion in an RB.
Brightest cluster galaxies (BCGs) residing in cool-core clusters are known to be the stage of intricate baryon cycle phenomena (e.g. gas inflows, AGN outflows, star formation feedback). The scenarios describing the observed properties of these galaxies are still controversial, suffering from limitations due to the spatial resolving power of the instruments, specifically for galaxies beyond the Local Universe. However, the dramatic improvements introduced by the integral-field unit instruments (e.g. MUSE) could shed light on the physical processes driving the evolution of these galaxies. We present an extensive analysis of the stellar and gas properties (i.e. kinematics, stellar mass, star formation rate) of the radio-loud BCG sitting at the centre of the X-ray luminous cool-core cluster Abell 2667 (z = 0.23), based on MUSE data. Our results indicate that the BCG is a massive elliptical, hosting an AGN that is possibly undergoing accretion of cold star-forming clouds of ICM or galactic cannibalism.
Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.
Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.
CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.
Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.
Pottery-manufacturing sequences can act as proxies for human migration and interaction. A good example is provided by the ‘spiralled patchwork technology’ (SPT) identified at two key early farming sites in the Ligurian-Provencal Arc in the north-west of the Italian peninsula. SPT is distinct from the ceramic technology used by early farmer communities in south-east Italy that shows technical continuity with the southern Balkans. Macroscopic analysis and micro-computed tomography suggests the presence of two communities of practice, and thus two distinct social groups in the northern Mediterranean: one of southern Balkan tradition, the other (associated with SPT) of as yet unknown origin. The identification of SPT opens up the exciting possibility of tracing the origins and migrations of a second distinct group of early farmers into Southern Europe.
Depression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.
To confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.
The sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT.
In the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β=0.12, P = 2.7 × 10−4) and with the Han/Eskin random effects method (P = 1.4 × 10−7) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10−8). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTO.
This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
The points where the horizontal component of the geomagnetic field vanishes are located in polar areas, far away from the geomagnetic (analytic) poles and the poles of rotation of the Earth and, differently from the geomagnetic poles, can be found experimentally with a magnetic survey to determine where the field is vertical. The experimental determination of the area where the total field is perfectly vertical, commonly known as dip pole, is not simple, due to the remoteness and harsh climatic conditions; another difficulty is related to the short term geomagnetic field variations, due to the interaction with the external solar wind, which causes the magnetospheric dynamics, particularly evident at high latitude, and as a consequence a displacement of the dip pole. Actually, the study of the dip pole displacements over short time scales can be an important tool for monitoring the magnetospheric dynamics at high latitude. In this study we present the updated location of the the dip poles, using data from the Swarm ESA’s constellation of satellites along their almost polar orbits. We also analyse the spatial shift of these areas during different seasons and interplanetary magnetic field orientations.
Previous research has demonstrated that late and sequential applications of glyphosate and glufosinate can have adverse effects on glyphosate- and glufosinate-resistant canola. Similarly, imidazolinone (IMI)-resistant canola may be affected negatively by late applications of imidazolinone herbicides. Field trials were established across the Northern Great Plains region from 2010 to 2012 to examine the response of IMI-resistant canola yield, yield components, and seed quality to late and sequential applications of imazamox. Plots received either a single imazamox application at the two-leaf, six-leaf, bolt, or early bloom stages or sequential applications at the two-leaf followed by six-leaf, two-leaf followed by bolting, and two-leaf followed by early bloom stages; an unsprayed control was included for comparisons. Results indicated that in most site-years there was no effect of imazamox application timing on IMI-resistant canola yield, yield components, or seed quality. These results suggest that late and sequential applications of imazamox to IMI-resistant canola should have little effect on canola production, even if they are made beyond the recommended six-leaf stage. In situations where growers are forced to make late applications (beyond six leaves) to IMI-resistant canola, using solely imazamox appears to minimize adverse effects on seed yield and quality.
The development of glyphosate-resistant canola has provided improved weed-management options for growers, but crop tolerance to glyphosate may be inadequate at later growth stages. In this study, glyphosate-resistant canola 45H28 (RR) was used to determine the effects of glyphosate application timing on yield and yield components at several sites in western Canada. Canola received a single glyphosate applications at the two-leaf, six-leaf, bolting, and early bloom stages and sequential applications at the two-leaf + six-leaf, two-leaf + bolting, and two-leaf + early bloom stages. Contrasts were made between early vs. late, single vs. sequential, and on-label (two to six-leaf stage) vs. off-label (above six-leaf stage). In general, differences between application timings were observed for yield and yield components in 3 of 8 site-yr. Off-label applications of glyphosate (later than six-leaf) significantly decreased yield, seeds per pod, and increased thousand-seed weight and aborted pods in canola at the Lethbridge and St. Albert locations. Increased glyphosate translocation because of adequate, but not excessive, moisture to new growth may have suppressed new seed formation and encouraged pod abortion at the time of application in the 2010 and 2011 seasons. Results from this experiment demonstrate the importance of proper application timing of glyphosate on canola and can help better predict the effects of late applications.
Photovoltaic (PV) systems are progressively used for decentralized electricity generation. To obtain the maximum yield from such systems, optimisation of all components is essential. In this contribution, we provide a comprehensive modelling and sizing of PV systems for any location. Three applications are here presented providing real time monitoring of PV potential, accurate prediction of yield taking into account thermodynamic temperature effects, optimization of modules orientation addressing the effects of shading and efficient sizing of inverter for a higher yield output. When combined, these models can accurately predict the real time performance of any PV system.
Horseweed is a surface-germinating ruderal facultative winter annual. The ruderal nature is a key adaptive characteristic that implicates emergence timing as an important recruitment factor. Experiments were established at three sites in southern Ontario, Canada, from 2009 to 2012 to determine the possible effect of emergence timing of horseweed on plant number, fecundity, and flowering timing. Emerged seedlings were tagged in 0.25-m2 plots in five 2-wk cohorts in the fall and spring of each experimental season. Each plot was followed though until the plants contained within each plot completed their life cycle. Generally, spring-emerging plants were found to flower earlier than fall-emerging plants, but with fall emergence there were higher plant densities in August each season compared with spring emergence. Overall, there was no difference in fecundity between spring- or fall-emerging cohorts, but when cohorts were parsed beyond just spring or fall emergence, we found that plants emerging in early fall and early spring were more fecund and flowered earlier than plants emerging in late fall and late spring. Disturbance (tilled versus not-tilled) significantly affected emergence levels but not emergence timing. The differences in performance among emergence cohorts are likely due to spatial or temporal density-dependent growth advantages. These results show that spring-emerging cohorts of horseweed, especially early spring–emerging cohorts, should not be discounted when considering the weediness of this species, and this may hold true for other facultative winter annual weeds as well.
With the goal of investigating the link between black hole (BH) and star formation (SF) activity, we study a deep sample of radio selected star forming galaxies (SFGs) and active galactic nuclei (AGNs). Using a multi-wavelength approach we characterize their host galaxies properties (stellar masses, optical colors, and morphology). Moreover, comparing the star formation rate derived from the radio and far-infrared luminosity, we found evidences that the main contribution to the radio emission in the radio-quiet AGNs is star-formation activity in their host galaxy.
We present our very recent results on the sub-mJy radio source populations at 1.4 GHz based on the Extended Chandra Deep Field South VLA survey, which reaches ~ 30 μJy, with details on their number counts, evolution, and luminosity functions. The sub-mJy radio sky turns out to be a complex mix of star-forming galaxies and radio-quiet AGN evolving at a similar, strong rate and declining radio-loud AGN. While the well-known flattening of the radio number counts below 1 mJy is mostly due to star-forming galaxies, these sources and AGN make up an approximately equal fraction of the sub-mJy sky. Our results shed also light on a fifty-year-old issue, namely radio emission from radio-quiet AGN, and suggest that it is closely related to star formation, at least at z ~ 1.5 − 2. The implications of our findings for future, deeper radio surveys, including those with the Square Kilometre Array, are also discussed. One of the main messages, especially to non-radio astronomers, is that radio surveys are reaching such faint limits that, while previously they were mainly useful for radio quasars and radio galaxies, they are now detecting mostly star-forming galaxies and radio-quiet AGN, i.e., the bulk of the extragalactic sources studied in the infrared, optical, and X-ray bands.
Although usually thought of as external environmental stressors, a significant heritable component has been reported for measures of stressful life events (SLEs) in twin studies.
We examined the variance in SLEs captured by common genetic variants from a genome-wide association study (GWAS) of 2578 individuals. Genome-wide complex trait analysis (GCTA) was used to estimate the phenotypic variance tagged by single nucleotide polymorphisms (SNPs). We also performed a GWAS on the number of SLEs, and looked at correlations between siblings.
A significant proportion of variance in SLEs was captured by SNPs (30%, p = 0.04). When events were divided into those considered to be dependent or independent, an equal amount of variance was explained for both. This ‘heritability’ was in part confounded by personality measures of neuroticism and psychoticism. A GWAS for the total number of SLEs revealed one SNP that reached genome-wide significance (p = 4 × 10−8), although this association was not replicated in separate samples. Using available sibling data for 744 individuals, we also found a significant positive correlation of R2 = 0.08 in SLEs (p = 0.03).
These results provide independent validation from molecular data for the heritability of reporting environmental measures, and show that this heritability is in part due to both common variants and the confounding effect of personality.
Since the decade of 1980, the model of stress and coping proposed for the assessment of vulnerability of adoptive families emphasizes that the emotional adjustment of those adopted is moderated by variables such as institutionalization, the manner and age at which the adoption was revealed, the change of first name, and the contact with the biological family. The objective of this study was to investigate the relationship of these variables to the perceived parenting style, mood, and self-esteem of the adopted adolescents. Participants in the study were 68 adolescents, between the ages of 14 and 15, adopted during infancy through judicial channels. The adolescents responded to a questionnaire about the history of adoption and to scales of Parenting Styles, Depression and Self-esteem. The main results indicated that the late revelation of adoption and the change of the first name are connected to higher levels of depression and low self-esteem and to more frequent perceptions of negligent or authoritarian parenting style. The contact with the biological family was frequently mentioned among those who perceived their parents as authoritative and presented the best indicator of mood and self-esteem. These findings were discussed in light of the necessity for multidisciplinary actions which can improve the psychological adaptation of the adopting families.
From March to October 1993. 15 cases of haemolytic-uraemic syndrome (HUS) in children were detected in a large area of northern Italy, where only 8 cases had occurred in the previous 5 years. Analysis of stool and serum specimens obtained from 14 cases showed evidence of Verotoxin-producing Escherichia coli (VTEC) infection in 13. Serum antibodies to the E. coli O157 lipopolysaccharide (LPS) were found in 8 patients and to the O111 LPS in 2. An O86 VTEC was isolated from another patient. Fourteen children needed dialysis, and 1 died. No obvious epidemiologic link was observed among cases, most of whom lived in small townships. A case-control study did not show an association between HUS and food or exposure to cattle, but suggested an association with contact with chicken coops (OR = 6·5. 95% C.I. 1·2–34·9). However, VTEC were not isolated from stool samples obtained from the chicken coops involved. The risk factors for VTEC infection related to living in rural settlements, including the exposure to live poultry, should be considered in outbreak investigations.