Cognitive-behaviour therapy (CBT) for panic disorder may consist of different combinations of several therapeutic components such as relaxation, breathing retraining, cognitive restructuring, interoceptive exposure and/or in vivo exposure. It is therefore important both theoretically and clinically to examine whether specific components of CBT or their combinations are superior to others in the treatment of panic disorder. Component network meta-analysis (NMA) is an extension of standard NMA that can be used to disentangle the treatment effects of different components included in composite interventions. We searched MEDLINE, EMBASE, PsycINFO and Cochrane Central, with supplementary searches of reference lists and clinical trial registries, for all randomized controlled trials comparing different CBT-based psychological therapies for panic disorder with each other or with control interventions. We applied component NMA to disentangle the treatment effects of different components included in these interventions. After reviewing 2526 references, we included 72 studies with 4064 participants. Interoceptive exposure and face-to-face setting were associated with better treatment efficacy and acceptability. Muscle relaxation and virtual-reality exposure were associated with significantly lower efficacy. Components such as breathing retraining and in vivo exposure appeared to improve treatment acceptability while having small effects on efficacy. The comparison of the most v. the least efficacious combination, both of which may be provided as ‘evidence-based CBT,’ yielded an odds ratio for the remission of 7.69 (95% credible interval: 1.75 to 33.33). Effective CBT packages for panic disorder would include face-to-face and interoceptive exposure components, while excluding muscle relaxation and virtual-reality exposure.

Intraspecific variation of organisms is of great importance to correctly carry out taxonomic work, which is a prerequisite for key disciplines in paleontology such as community paleoecology, biostratigraphy, and biogeography. However, intraspecific variation is rarely studied in ectocochleate cephalopods (ammonoids and nautiloids), for which an excessive number of taxa was established during the past centuries. Because intraspecific variation of fossilized organisms suffers from various biases (time averaging and taphonomy), an extant example is needed for actualistic comparison. We applied 3D morphometry to 93 specimens of Nautilus pompilius from three different geographic populations. This data set was used to examine the intraspecific variation throughout ontogeny in detail. Although there are slight differences between the populations as well as some measurement biases, a common pattern of intraspecific variation appears to be present. High variation in morphometric variables appears early in ontogeny and then decreases gradually in the following ontogenetic stages. Subsequently, the variation shows an increase again before maturity until a sharp increase or decrease occurs toward the end of ontogeny. Comparison with intraspecific variation of ammonoids and belemnites illustrated that some groups have ontogenetic patterns of intraspecific variation that are similar to that of N. pompilius. This implies that the abovementioned ontogenetic pattern of intraspecific variation might be common in some major cephalopod clades.

Recent discovery of extrasolar planets indicates that some of them have much higher eccentricity than the planets in the solar system. Here, we investigate the climate of such eccentric terrestrial planets with oceans and carbonate-silicate geochemical cycles. We find that the climate of the planets are dependent on the annual mean insolation as shown in previous works. We also find that the planets orbiting slightly further from our Sun than the Earth are globally ice-covered even if the carbonate-silicate geochemical cycle works under the same CO2 degassing rate as on the present Earth. However, when the CO2 degassing rate is higher, the planets avoid being globally ice-covered owing to the high level.

We systematically investigated the climate of water-rich terrestrial planets with a negative feedback mechanism of carbonate-silicate geochemical cycle against the climate under various obliquities and semi-major axes. We found that, while the permanent ice-cap mode (partially ice-covered throughout the year) and the seasonal ice-cap mode (partially ice-covered seasonally) exist stably at low obliquity conditions, the ranges of semi-major axis for these climate modes shrink and finally disappear with an increase of obliquity. When carbonate-silicate geochemical cycle is taken into account, the ranges of semi-major axis for all the climate modes expand at any obliquities, compared with the cases without carbonate-silicate geochemical cycle, indicating that the carbonate-silicate geochemical cycle strongly stabilizes the climate for the planets with any obliquities inside the habitable zone.