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This article presents a comparative analysis of three Late Roman sites located at the northern outskirts of the Kharga Oasis in Egypt's Western Desert: Umm al-Dabadib, Ayn al-Labakha, and the Gib/Sumayra Complex. These were part of the district of the Oasis Magna, which included the oases of Dakhla and Kharga. An analysis of their layout, including both shape and extent, is followed by an evaluation of their absolute and relative positions. These data are then compared to the administrative and historical contexts within which the three sites flourished. Both administrative and economic aspects are considered, as well as the presence of the army. The complex picture that emerges suggests that these three sites played several roles at the same time and were part of a large-scale strategic design that encompassed not only the Kharga Oasis but the entire Western Desert.
The literature lacks methodologies to make supply chains of composite materials circular. The proposed approach aims to transform scraps and off-specification products into secondary raw materials. Its novelty is to find innovative applications, instead of re-introducing scraps in the loop they come from. The case study investigates how scraps can be re-worked and re-used as raw material. First, the processes are analyzed; some components are then re-designed to be made of the discarded scraps (composites material). Results reveal that the symbiosis can ensure green, high performing products.
Termite mounds have been poorly studied in tropical rainforest in contrast to those of savannahs where they create fertility hotspots and influence the spatial pattern of vegetation. An inventory of termite mounds and of 15 tree species with a diameter at breast height ≥ 10 cm was carried out in two 800-ha blocks, in two rainforest sites located in northern Congo. We used inhomogeneous and intertype K functions to study the spatial pattern of termite mounds and of tree species around mounds, respectively. We found that mounds in Loundoungou were over-dispersed within a radius of less than 70 m, while those in Mokabi were randomly spaced. Tree species within a 20-m radius around a mound were aggregated towards the mound, e.g. Entandrophragma cylindricum, randomly distributed, or even repulsed by the mound. The specific responses also differed in the two sites. These results suggest that (i) the mounds in Loundoungou were created by savannah termite species 3,000-2,000 years BP during the Late Holocene Rainforest Crisis and (ii) the mounds in Mokabi are characteristic of forest mounds. The impact of termite mounds on the spatial pattern of tree species is thus site-dependent, and these differences might be due to species seed dispersal strategies and to soil calcium concentrations.
Diabrotica speciosa is an important pest of several crops in South America, including soybeans. Adults cause severe defoliation in soybean plants, and damage is significant when cotyledons are attacked. This study evaluated feeding non-preference to D. speciosa adults using 10 soybean genotypes, testing (i) 15-day-old whole plants and (ii) leaf disks of 60-day-old plants, through assessments of soybean attractiveness and leaf area consumed (LAC). Foliar contents of flavonoids and nutrients, and leaf trichome density were quantified for potential correlations with soybean resistance to adult of D. speciosa. In the whole young-plant experiment, under free-choice conditions, the lowest LAC was observed in IAC 100 and PI 227687. In no-choice, PI 227687 and IGRA RA 626 RR showed lower LAC than the other genotypes. In the leaf disk test, in free-choice, the genotypes IAC 100, PI 274454, PI 227687, DM 339, and BR 16 were the least preferred by adult of D. speciosa. In no-choice, PI 274454 was one of the least preferred, similarly to IGRA RA 626 RR, Dowling, and PI 227687. In the whole plant experiment, a high rutin content and low amounts of zinc, calcium, sulfur and manganese were associated with less consumption of D. speciosa on leaves of resistant genotypes. In contrast, in the leaf disk test there was a significant influence of trichomes in soybean resistance to the pest. In conclusion, the PI lines herein assessed are also promising sources for developing cultivars resistant to D. speciosa.
This article investigates Classic Maya understandings of two particular animal species: the (gray) fox and the armadillo. We use these species as a point of entry into Classic Maya categorizations of the non-human animal world, examining the salient biological and physical characteristics of those animals that Classic-period artists and scribes chose to highlight. Rather than accepting the creatures depicted on painted pottery or referenced in hieroglyphic texts as generalized examples of particular kinds (i.e., simply “a fox” or “an armadillo”), however, we show how the evidence from ancient art, historical accounts, and contemporary ethnography points to an emphasis on specific beings, often named individuals, who engage in particular behaviors and relate to other entities (both human and non-human) in distinctive ways. Although this article focuses exclusively on the fox and the armadillo, those species serve as examples through which we consider the limitations of applying Western taxonomic categories to other systems of knowledge, as well as the possibilities for how we might catch glimpses of radically different ways of organizing the world.
Circulating branched-chain amino acids (BCAAs), a subgroup of the nine essential amino acids, have been associated to pancreatic cancer risk. The aim of this study is to estimate the relation between BCAA intake from diet and pancreatic cancer risk.
We analysed data from a multicentric Italian case-control study, including 326 pancreatic cancer cases and 652 controls, matched to cases by study centre, sex and age. A validated food-frequency questionnaire was used to collect the participants’ usual diet before cancer diagnosis (or hospital admission for controls) and to compute dietary intakes of various nutrients, including BCAAs. Odds ratios (ORs) and corresponding confidence intervals (CIs) were computed through logistic regression models conditioned on the matching variables and adjusted for major confounding factors, including total energy intake.
We found a positive association between the BCAA intake and pancreatic cancer risk (OR for the third quartile=1.88, 95% CI=1.08-3.26; OR for the fourth quartile =2.17, 95% CI=1.17-4.06), with a significant trend in risk. The association persisted after excluding subjects with diabetes and family history of pancreatic cancer, and across strata of selected covariates.
These data support and quantify the association between dietary BCAAs and pancreatic cancer, previously suggested by studies on circulating BCAAs.
Chapter 24 provides a history of thought on poetry translation ranging from the Roman poets translating Greek, to the experiments of Louis and Celia Zukovsky. They explore how poetic forms, for example the haiku and the sonnet, have been introduced to literary systems beyond their origins through translation, and how the poetry of the classical world has been reanimated through modernism’s shifts in practices and views of translation. They discuss the ‘translation’ of texts in a literary context by poets and versioners who may or may not read the source languages concerned. Throughout, the emphasis is on exemplification and on the connection between theoretical perspectives and paratextual reflection.
Let
$(A,\mathfrak m)$
be an excellent two-dimensional normal local domain. In this paper, we study the elliptic and the strongly elliptic ideals of A with the aim to characterize elliptic and strongly elliptic singularities, according to the definitions given by Wagreich and Yau. In analogy with the rational singularities, in the main result, we characterize a strongly elliptic singularity in terms of the normal Hilbert coefficients of the integrally closed
$\mathfrak m$
-primary ideals of A. Unlike
$p_g$
-ideals, elliptic ideals and strongly elliptic ideals are not necessarily normal and necessary, and sufficient conditions for being normal are given. In the last section, we discuss the existence (and the effective construction) of strongly elliptic ideals in any two-dimensional normal local ring.
The 1994 Argentine constitutional reforms introduced a plethora of economic, social and cultural rights to the text of the constitution, along with innovative procedural devices for vindicating those rights. More than two decades later, we have a wealth of experience with judicial interpretation and enforcement of these rights, and civil society use of the rights to pursue complex policy goals. This chapter explores that experience and describes the ways in which certain rights – such as the right to health, housing and a healthy environment – have been enforced through judicial orders. It focuses especially on the various ways in which courts have addressed the difficult task of designing, implementing and monitoring solutions to alleged violations of rights, when those violations have complex social and economic roots and any solutions consequently require extensive and long-term state involvement.
The practices adopted in dairy farms can positively or negatively affect the perception of consumers. To meet consumer expectations and improve the productivity of dairy farms, a welfare certification system has recently been initiated in Brazil. In this research communication we describe the perceptions of Brazilian consumers and farmers regarding the implementation of welfare certification systems and the most common practices that affect animal welfare on dairy farms. For this purpose, two semi-structured questionnaires were used: one applied to 409 consumers and the other to 158 dairy farmers. The results demonstrate that consumers are concerned with the adoption of welfare practices in animal husbandry at dairy farms, mainly on topics related to movement restriction and cow-calf separation. Thus, the majority of consumers state that they are willing to pay more for welfare-certified dairy products. In addition, most dairy farmers are interested in adopting a welfare certification system, especially if it could add value to the raw milk sold to industries. Veterinarians and animal scientists are important for disseminating animal welfare recommendations, and the consequences of its improper adoption need to be emphasized. Finally, dairy farms need improvements regarding environmental hygiene, thermal conditions, animal husbandry, health, and milking processes. In conclusion, consumers and farmers are interested in welfare systems and their certification, and there is a need for stakeholders to make welfare certification a reality in the Brazilian dairy supply chain.
People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, with a decade of years of life lost. In this randomized controlled trial (RCT), we assessed in a sample of people with bipolar disorder, major depressive disorder, and schizophrenia spectrum disorder, the efficacy of an innovative psychosocial group intervention compared to a brief psychoeducational group intervention on patients’ body mass index (BMI), body weight, waist circumference, Framingham and HOMA-IR indexes.
Methods
This is a multicentric RCT with blinded outcome assessments carried out in six Italian university centers. After recruitment patients were randomized to receive a 6-month psychosocial intervention to improve patients’ physical health or a brief psychoeducational intervention. All recruited patients were assessed with standardized assessment instruments at baseline and after 6 months. Anthropometric parameters and blood samples have also been collected.
Results
Four-hundred and two patients with a diagnosis of bipolar disorder (43.3%), schizophrenia or other psychotic disorder (29.9%), or major depression (26.9%) were randomly allocated to the experimental (N = 206) or the control group (N = 195). After 6 months, patients from the experimental group reported a significant reduction in BMI (odds ratio [OR]: 1.93, 95% confidence intervals [CI]: 1.31–2.84; p < 0.001), body weight (OR = 4.78, 95% CI: 0.80–28.27, p < 0.05), and waist circumference (OR = 5.43, 95% CI: 1.45–20.30, p < 0.05). Participants with impaired cognitive and psychosocial functioning had a worse response to the intervention.
Conclusions
The experimental group intervention was effective in improving the physical health in SMI patients. Further studies are needed to evaluate the feasibility of this intervention in real-world settings.
Formal reasoning about finite sets and cardinality is important for many applications, including software verification, where very often one needs to reason about the size of a given data structure. The Constraint Logic Programming tool
$$\{ log\} $$
provides a decision procedure for deciding the satisfiability of formulas involving very general forms of finite sets, although it does not provide cardinality constraints. In this paper we adapt and integrate a decision procedure for a theory of finite sets with cardinality into
$$\{ log\} $$
. The proposed solver is proved to be a decision procedure for its formulas. Besides, the new CLP instance is implemented as part of the
$$\{ log\} $$
tool. In turn, the implementation uses Howe and King’s Prolog SAT solver and Prolog’s CLP(Q) library, as an integer linear programming solver. The empirical evaluation of this implementation based on +250 real verification conditions shows that it can be useful in practice.
Under consideration in Theory and Practice of Logic Programming (TPLP)
Understanding of prefrailty’s relationship with limitations in activities of daily living (ADLs) moderated by psychological resilience is needed, as resilience might support ADLs’ maintenance and thus protect against frailty. Therefore, this study aims to analyze the influence of psychological resilience (using the Connor–Davidson Resilience Scale; CD-RISC) on the relation between ADLs and frailty status of older individuals (i.e. prefrail versus robust).
Design:
Cross-sectional design.
Setting:
UZ Brussels, Belgium.
Participants:
Robust (Fried 0/4;n = 214; Age = 82.3 ± 2.1yrs) and prefrail (Fried 1-2/4; n = 191; Age = 83.8 ±3.2yrs) community-dwelling older individuals were included.
Measurements:
Frailty scores were obtained from weight loss, exhaustion, gait speed, and grip strength. A total Disability Index (DI) expressed dependency for basic (b-), instrumental (i-), and advanced (a-)ADLs. Mediation was investigated by estimating direct and indirect effects of all levels of ADLs and CD-RISC total score on prefrailty/robustness using a stepwise multiple regression approach.
Results:
Prefrailty/robustness significantly correlated with a-ADL-DI (point-biserial correlation (rpb) = 0.098; p<0.05). Adjusted for age and gender, the a-ADL-DI (p<0.05) had a significant protective direct effect against prefrailty. No effects were found with the CD-RISC total score.
Conclusions:
Less limitation in a-ADLs is a directly correlated factor of prefrailty and might represent a higher likelihood of robustness.
We address the question of identifying the long-term (secular) stability regions in the semi-major axis-eccentricity projected phase space of the Sun-Jupiter planar circular restricted three-body problem in the domains i) below the curve of apsis equal to the planet’s orbital radius (ensuring protection from collisions) and ii) above that curve. This last domain contains several Jupiter’s crossing trajectories. We discuss the structure of the numerical stability map in the (a,e) plane in relation to manifold dynamics. We also present a closed-form perturbation theory for particles with non-crossing highly eccentric trajectories exterior to the planet’s trajectory. Starting with a multipole expansion of the barycentric Hamiltonian, our method carries out a sequence of normalizations by Lie series in closed-form and without relegation. We discuss the applicability of the method as a criterion for estimating the boundary of the domain of regular motion.
A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to the number of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing polygenic vulnerability. Here, we investigated, in the largest sample of first-episode psychosis (FEP) cases to date, whether childhood adversity and high polygenic risk scores for schizophrenia (SZ-PRS) combine synergistically to increase the risk of psychosis, over and above the effect of each alone.
Methods
We assigned a schizophrenia-polygenic risk score (SZ-PRS), calculated from the Psychiatric Genomics Consortium (PGC2), to all participants in a sample of 384 FEP patients and 690 controls from the case–control component of the EU-GEI study. Only participants of European ancestry were included in the study. A history of childhood adversity was collected using the Childhood Trauma Questionnaire (CTQ). Synergistic effects were estimated using the interaction contrast ratio (ICR) [odds ratio (OR)exposure and PRS − ORexposure − ORPRS + 1] with adjustment for potential confounders.
Results
There was some evidence that the combined effect of childhood adversities and polygenic risk was greater than the sum of each alone, as indicated by an ICR greater than zero [i.e. ICR 1.28, 95% confidence interval (CI) −1.29 to 3.85]. Examining subtypes of childhood adversities, the strongest synergetic effect was observed for physical abuse (ICR 6.25, 95% CI −6.25 to 20.88).
Conclusions
Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates.
Spatial units typically vary over many of their characteristics, introducing potential unobserved heterogeneity which invalidates commonly used homoskedasticity conditions. In the presence of unobserved heteroskedasticity, methods based on the quasi-likelihood function generally produce inconsistent estimates of both the spatial parameter and the coefficients of the exogenous regressors. A robust generalized method of moments estimator as well as a modified likelihood method have been proposed in the literature to address this issue. The present paper constructs an alternative indirect inference (II) approach which relies on a simple ordinary least squares procedure as its starting point. Heteroskedasticity is accommodated by utilizing a new version of continuous updating that is applied within the II procedure to take account of the parameterization of the variance–covariance matrix of the disturbances. Finite-sample performance of the new estimator is assessed in a Monte Carlo study. The approach is implemented in an empirical application to house price data in the Boston area, where it is found that spatial effects in house price determination are much more significant under robustification to heterogeneity in the equation errors.
The COVID-19 epidemic that spread in Italy in the early 2020, together with the general lockdown, are high-risk events for vulnerable populations who need high levels of assistance, such as patients with eating disorders (EDs).
Objectives
To evaluate the impact of the COVID-19 epidemic and lockdown on subjects suffering from EDs, considering previous vulnerabilities.
Methods
74 patients with anorexia nervosa (AN) or bulimia nervosa (BN) already on treatment and 97 healthy controls were evaluated between November 2019/January 2020 (T1), and again in April 2020, 6 weeks after the start of lockdown (T2). Patients were also evaluated at baseline (T0). At each assessment, general and ED psychopathology (SCL-90-R and EDE-Q) were assessed. Childhood abuse experiences (CTQ) and adult attachment (ECR-R) were investigated at T1, and post-traumatic stress symptoms (IES-R) at T2.
Results
Patients reported a significant increase in compensatory exercise; in addition, patients with BN and those who achieved remission at T1 showed a significant exacerbation of binge-eating. The longitudinal trend (T1-T2) of psychopathology was not different between patients and controls, however the expected benefit from treatment on ED psychopathology was significant only for AN, while no changes were noted in BN. Patients with BN reported more severe post-traumatic stress symptoms than AN and controls, and these symptoms correlated positively with prior traumatic experiences and an insecure attachment style.
Conclusions
The COVID-19 epidemic and lockdown had a significant impact on subjects with eating disorders, both by interfering with the treatment process and in terms of post-traumatic stress symptoms.
It is not known with certainty how different phenotypes are transmitted in groups of families divided into three generations.
Objectives
Having meticulously searched for terms of psychopathogic lexicon that best translated the sterile categorical diagnosis, we obtained three dimensional groups for all six families in the three generations.
Methods
We calculated the frequencies and percentages of the three dimensional groups for the three generations of families based on sex.
Results
The chi-square TEST attests a p-value = 0.049, statistically significant for the dimensional group “A”. (Tab. 3)
Conclusions
The genetics, and above all the epigenetics, of the phenotypes are periodically transmitted in group “A” and group “C” in the female and male sex. (Graphs 2.1.1 and 2.3.1) Different phenotypes indicate that the complexity of the interactions of the regulatory mechanisms of genes with the environment is extremely significant for the group with the most severe psychiatric pathology.
Sexual dysfunction is common in eating disorders (EDs), but its relevance is often overlooked.
Objectives
To describe different ED clinical subgroups in terms of psychopathology, putative biological correlates, and consequences of dysregulated sexuality, focusing on the role of childhood trauma.
Methods
Healthy controls (n=60), binge-purging (n=38), and restricting patients (n=24) were compared (age- and BMI-adjusted ANOVA; Bonferroni post-hoc tests), using total scores of Eating Disorder Examination Questionnaire (EDE-Q), Emotional Eating Scale (EES), SCL-90-R Global Severity Index (GSI), Barratt Impulsiveness Scale (BIS-11), Difficulties in Emotion Regulation Scale (DERS), Childhood Trauma Questionnaire (CTQ), Female Sexual Functioning Index (FSFI), Hypersexual Behaviour Inventory (HBI), and patients’ hormonal profiles (gonadal and pituitary hormones, ghrelin). Self-reported voluntary termination of pregnancy (VTP) and promiscuous sexual activity were recorded. For ED patients (N=62), regression analyses between significant variables and HBI were carried, applying moderation models for different CTQ scores.
Results
Table 1 outlines significant between-group comparisons (°: different from controls; *: different from restricting patients; p<0.05). Binge-purging patients had higher FSH, LH, and ghrelin levels, more VTPs and promiscuity. HBI showed significant correlations with EES, SCL-90-R-GSI, DERS, CTQ, and ghrelin levels. CTQ moderated interactions for DERS and EES (Figure 1).
Binge-purging
Restricting
Controls
F
EDE-Q
3.86±1.20°
3.41±1.64°
0.85±0.83
67.32
EES
40.85±22.74°*
16.01±15.88
19.87±15.21
7.01
SCL-90-R GSI
1.73±0.65°
1.27±0.69°
0.68±0.44
20.32
BIS-11
62.47±9.91°
60.81±8.56
57.04±10.04
4.99
DERS
106.97±29.15°*
83.97±33.12
78.14±14.12
10.21
CTQ
55.32±21.06°
49.31±10.81°
38.02±8.32
15.24
FSFI
17.32±11.89°*
11.70±10.98°
29.32±7.45
24.02
HBI
28.75±13.89*
20.56±3.12
26.11±4.90
4.92
Conclusions
Dysregulated sexuality is linked to emotion dysregulation and childhood trauma. Binge-purging patients experience adverse behavioural consequences.