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We don’t know what Darwin is doing right now; maybe he’s playing backgammon with Isaac Newton, as they rest in Westminster Abbey. Darwin and Newton are two icons of biology and physics. And biology and physics have been two key topics of your life, decades before becoming President of the Royal Society, which lists among its highest honours the Darwin Medal.
We sought to examine the influence of clinically severe lower respiratory tract infection on pulmonary artery pressure in children having CHD with post-tricuspid left-to-right shunt, as it may have physiological and clinical implications. In a prospective single-centre observational study, 45 children with post-tricuspid left-to-right shunt and clinically severe lower respiratory tract infection were evaluated during the illness and 2 weeks after its resolution. Pulmonary artery systolic pressure was estimated non-invasively using shunt gradient by echocardiography and systolic blood pressure measured non-invasively.
Median pulmonary artery systolic pressure during lower respiratory tract infection was only mildly (although statistically significantly) elevated during lower respiratory tract infection [60 (42–74) versus 53 (40–73) mmHg, (p < 0.0001)]. However, clinically significant change in pulmonary artery systolic pressure defined as the increase of >10 mmHg was present in only 9 (20%) patients. In the absence of hypoxia or acidosis, only a small minority (9%, n = 4) showed significant pulmonary artery systolic pressure rise >10 mmHg. In the absence of hypoxia or acidosis, severe lower respiratory tract infection in patients with acyanotic CHD results in only mild elevation of pulmonary artery systolic pressure in most of the patients.
To more effectively investigate, diagnose, and treat mood disorders, there is a need to move beyond standard clinical characterizations. While symptom-based nosology has provided a reliable and pragmatic framework for clinical practice, advances in neuroimaging research have permitted the possibility of identifying neurophysiologic biomarkers that index underlying pathophysiologic processes and provide an effective complement to clinical symptoms. Functional magnetic resonance imaging (fMRI) is one of the common state-of-the-art neuroimaging approaches for investigating brain disorders and has been very useful in providing a functional neuroanatomic account of neural disturbances in mood disorders.
A 14-year-old girl admitted for corrective surgery for tetralogy of Fallot was found to have pulmonary arteriovenous malformations on pre-operative evaluation. In anticipation of a complicated postoperative course, percutaneous closure of the pulmonary arteriovenous malformations was undertaken first followed by a successful surgical outcome. Importance of this rare association and its clinical implication is hereby highlighted.
takes a deeper examination of the dynamics that produce advancements in progressive state citizenship, with cases from both the historical and contemporary periods: the two-decade push for driver’s licenses in California and New York, the timing and spread of state sanctuary laws on immigration since 2005, and a historical examination of Black state citizenship in the antebellum North. Using the Advocacy Coalition Framework (ACF) of policy change, the authors argue that some of the most notable legislative advancements in progressive state citizenship have occurred because of the intersection of two key factors: state advocacy coalitions that unite strong social movement actors and legislative champions alike, combined with policy openings created by federalism tensions. The chapter concludes by offering thoughts on the future of progressive state citizenship in a politically polarized United States.
turns to immigrant citizenship with a focus on California to carefully assess where the state currently stands with respect to progressive state citizenship and to situate the present moment in a sweep of the state’s history, which saw it pioneer and champion anti-Chinese and anti-immigrant legislation from its founding through the late 1990s and only move toward more pro-immigrant policies in the last two decades. We then explore key milestones in immigrant rights over the past decade and pinpoint 2015 as the year when progressive state citizenship became crystallized. Finally, we trace key factors that incubated and enabled the development of progressive state citizenship in California, including voter backlash against racial propositions, partisan shifts in the state legislature, and the growing strength of social movement actors across various regions, aided by long-term investment strategies by private foundations.
examines the development of Black citizenship, beginning with a stark reminder that blacks had no access to national citizenship rights in the antebellum period, even though there were more than 435,000 free Blacks living in the United States at the time of the Supreme Court’s 1857 Dred Scott ruling. The Framers’ Constitution had accommodated the interests and demands of slaveholding states at the time of ratification and thus gave much greater power to states than the federal government in setting citizenship rights. The constitutional framework structuring black citizenship changed significantly after the Civil War, as new forms of regressive state citizenship emerged against the backdrop of Reconstruction and decades of Jim Crow, followed by rapid changes in the Civil Rights period that continues until today. Throughout this chapter, the authors train their focus on the role of the Constitution and courts in defining and constraining Black citizenship rights, as well as the role of parties and social movement actors in propelling legislative action toward rights expansion and contraction.
focuses on the particular case of the United States and the development of national citizenship and state citizenship over time. Following the lead of other works in American history and American Political Development, the authors lay out three major periods in federated citizenship that follow significant developments in the US Constitution and federal law: the Framers’ period, stretching from the Articles of Confederation and the founding Constitution through the Civil War; the Reconstruction period’s establishment and subsequent collapse of national control ensuring the provision of those citizenship rights under Jim Crow; and the Civil Rights period, starting with the Twenty-Fourth Amendment and the Civil Rights Act of 1964, the Voting Rights Act of 1965, the Immigration and Nationality Act of 1965, and subsequent extensions and contractions in citizenship rights provided at the national and state levels along lines of race, gender, immigrant status, and sexual orientation.
outlines the history of citizenship as a political concept, showing that the dominant view of citizenship today is still primarily seen as nationally provided and tied inextricably to legal status, despite global and urban scholars challenging its claims of exclusivity and immigration scholars challenging its singular focus on legal status. The limited power of these critiques is due, in part, to the fuzziness of claims regarding rights and identities. The authors make a fresh start in the systematic conceptualization of citizenship, showing that legal status is not the gateway to rights as is often assumed. In its place, they develop a concept of federated citizenship as a parallel set of rights along five key dimensions, with the provision of those rights varying by jurisdiction – federal, state, and local. They also lay out important differences between progressive citizenship, regressive citizenship, and reinforcing citizenship. Finally, they move from concept formation to the development of indicators for state citizenship regimes, which sets the stage for the empirical analysis is subsequent chapters on Black citizenship rights and immigrant citizenship rights.
The United States is entering a new era of progressive state citizenship, with California leading the way. A growing number of states are providing expanded rights to undocumented immigrants that challenge conventional understandings of citizenship as binary, unidimensional, and exclusively national. In Citizenship Reimagined, Allan Colbern and S. Karthick Ramakrishnan develop a precise framework for understanding and measuring citizenship as expansive, multi-dimensional, and federated - broader than legal status and firmly grounded in the provision of rights. Placing today's immigration battles in historical context, they show that today's progressive state citizenship is not unprecedented: US states have been leaders in rights expansion since America's founding, including over the fight for black citizenship and women's suffrage. The book invites readers to rethink how American federalism relates to minority rights and how state laws regulating undocumented residents can coexist with federal exclusivity over immigration law.