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Depression is highly prevalent in children and adolescents in Pakistan, yet, factors affecting depression have not been widely studied. This study aims to assess the demographic and clinical characteristics of depression in children and adolescents and identify associations between parental marital status and confounding factors for depression.
A descriptive retrospective study was undertaken at the Aga Khan University Hospital in Karachi, Pakistan. Patient records of children and adolescents (aged under 18 years), presenting to the psychiatry clinic with depression from 2015-2019 were reviewed. The diagnosis of clinical depression was made based on clinical assessment according to international guidelines. Patients whose medical records had missing information were excluded. Data were analysed using IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, N.Y., USA). Continuous data are presented as mean +/- standard deviation, whereas categorical data are presented as percentages (%). Pearson Chi-square test of association has been used to assess the association between parental factors and confounding factors. In instances where Pearson's Chi-square test could not be applied, Fisher's exact test is used instead. Associations at p <0.05 (95% confidence limit) are considered statistically significant.
A total of 133 participants were included, of which 78 (58.6%) were female, and 55 (41.4%) were male, with a mean age of 15.5 +/- 2.4 (Range: Ages 4–18). The population had a 50.4% prevalence of suicidal ideation, 21.1% of self-harm, 15% of substance abuse and 14.3% of suicide attempts. Academic stress (54.9%), inter-parental conflict (30.1%) and child abuse (29.3%) were the most common confounding factors reported. Other confounding factors include a family history of depression (20.3%), experience of bullying (16.5%) witnessing domestic violence (16.5%), substance abuse (15.0%) and experiencing sexual abuse (6.0%). There is a statistically significant association between children having parents with non-intact marriages and experiencing sexual abuse (p < 0.001, Odds Ratio (OR) = 21.48), having a family history of depression (p < 0.001, OR = 7.04), child abuse (OR = 3.78). Children of non-traditional (not living with both parents) families were more likely to witness domestic violence (p < 0.001, OR = 4.28), have a family history of depression (p < 0.001, OR = 3.44), abuse substances (OR = 3.20) and experience child abuse (OR = 2.48).
This study identifies factors that may put children at an increased risk of developing depression and performing high-risk behaviours. The findings can help develop better screening programs and counselling for children and adolescents, allowing prevention and ensuring early diagnosis and care.
After the WHO declaration of the COVID-19 pandemic intense scuffling against novel coronavirus was observed and established fatal in most regions of the world. High fatality rate and socioeconomic downfall affected the health of non victimized individuals and consequently, health care measures, scheduled clinical and hospital visits avoided by the population hence the adaptation of self-medication proved as the mere troubleshooter for the general population as a swift safeguard for the further possible vulnerable situation. The present study is designed to observe the adaptability of self-medication with pros and cons due to the involved factors of fear of coronavirus, among the general population and for purpose, a questionnaire on the Zenodo-scale was developed and asked to respond from adults and teens after taking consensus, that further analyzed through IBM SPSS Statistics Version 26.
The outcome study was amazingly found with high compliance with self-medication among the focused population during the period of COVID. Estimated results showed highly significant correlation 0.000, p< 0.05 between the adaptation of self-medication and pandemic situation, which was estimated from Chi-square and Fisher tests. However, the fear of coronavirus made the practice or malpractice a survival of fittest, an embedded ability of human nature.
High levels of stress are expected when crises affect people’s lives. Therefore, this Web-based, cross-sectional study was conducted among university students from Pakistan to investigate the psychological impairment and coping strategies during the coronavirus disease 2019 (COVID-19) pandemic. Google Forms were used to disseminate the online questionnaire to assess anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-9), and coping strategies (Brief-COPE). A total of 1134 responses (age, 21.7 ± 3.5 y) were included. The frequency of students having moderate-severe anxiety and depression (score ≥ 10) were ≈ 34% and 45%, respectively. The respondents’ aged ≥ 31 y had significantly lower depression score than those ≤ 20 y (P = 0.047). Males had significantly less anxiety (6.62 ± 5.70 vs 7.84 ± 5.60; P = 0.001) and depression (8.73 ± 6.84 vs 9.71 ± 7.06; P = 0.031) scores. Those having family members, friends, or acquaintances infected with disease had significantly higher anxiety scores (8.89 ± 5.74 vs 7.09 ± 5.56; P < 0.001). Regarding coping strategies, the majority of respondents were found to have adopted religious/spiritual coping (6.45 ± 1.68) followed by acceptance (5.58 ± 1.65), self-distraction (4.97 ± 1.61), and active coping (4.81 ± 1.57). In conclusion, COVID-19 caused significant impairment on mental health of the students. The most frequent coping strategies adopted by students were religious/spiritual and acceptance coping. During epidemics, mental health of students should not be neglected.
Understanding differences in social-emotional behavior can help identify atypical development. This study examined the differences in social-emotional development in children at increased risk of an autism spectrum disorder (ASD) diagnosis (infant siblings of children diagnosed with the disorder). Parents completed the Brief Infant-Toddler Social-Emotional Assessment (BITSEA) to determine its ability to flag children with later-diagnosed ASD in a high-risk (HR) sibling population. Parents of HR (n = 311) and low-risk (LR; no family history of ASD; n = 127) children completed the BITSEA when their children were 18 months old and all children underwent a diagnostic assessment for ASD at age 3 years. All six subscales of the BITSEA (Problems, Competence, ASD Problems, ASD Competence, Total ASD Score, and Red Flags) distinguished between those in the HR group who were diagnosed with ASD (n = 84) compared to non-ASD-diagnosed children (both HR-N and LR). One subscale (BITSEA Competence) differentiated between the HR children not diagnosed with ASD and the LR group. The results suggest that tracking early social-emotional development may have implications for all HR children, as they are at increased risk of ASD but also other developmental or mental health conditions.
It is reported recently that sK-channels have implications in learning and memory processes and may serve as a potential target of memory impairment. Till now there is no in vitro data available on effect of sK-channel with respect to network oscillation that regulates consciousness based learning and memory tasks. In the present study we have test the effect of CyPPa on kainate-induced gamma oscillations.
For induction of gamma oscillations in acute hippocampal slices from adult rats bath application of kainic acid 100 nM is used. Once the gamma oscillations have been stabilized, CyPPa is added into kainte solution to test its effect at 20 and 100 μM concentration.
CyPPa (100 μM, n=6) blocked gamma oscillations in 25 ± 3min, increased in peak power is observed within 15 ± 3min of CyPPa application. Whereas, CyPPa (20 μM, n=6) blocked gamma oscillations induced by kainate 100 nM in 38 ± 5min. Further we have analyzed the effect of CyPPa on total peak power and power of dominant frequencies in bands (p < 0.05).
We may conclude the network activity is altered by sK-channel agosnit Cyppa and resulted in overall reduction of network oscillatory activity in hippocampus.
The seventh chapter, ‘A Dream Deferred’, explores how the dream and utopian promise of interwar internationalism faded during the upheavals of the Second World War and a violent decolonization. The Left in India was forced to choose between internationalism and nationalism. Through the lives and politics of those involved in this fateful choice, I examine the CPI’s position with respect to the ‘People’s War’ waged by the Soviet Union against Nazi Germany and the demand for Pakistan by the All India Muslim League (AIML). As its political choices narrowed in the run-up to independence, I trace how the communists’ internationalist loyalties placed it in a mutually acrimonious relationship with the presumptive heirs of the Raj in India and Pakistan. In a far cry from its heyday in the early years of the interwar period, when there seemed little to separate internationalism and nationalism, the manifold possibilities imagined by Communist Internationalism seemed at an end in the devastation wrought by Partition.
The fifth chapter, ‘Entangled Histories’, starts from the question of erasure. I examine how the memorialization of revolutionary pasts in India and Pakistan has erased a history of entanglements between the Left and other political and intellectual strands. Specifically, I take the case of Darshan Singh Pheruman, remembered today as a martyr who gave his life for the Sikh Panth. Through his life, I examine how the Akali movement, a Sikh socio-religious political movement in the 1920s, blended in with the communist movement in the Punjab. These intersections provide a reminder of how ideas did not observe strict ideological boundaries, boundaries that only seem unbridgeable in nationalist and communitarian erasures of revolutionary pasts. This chapter offers a portrait of the relative fluidity between ‘communist’, ‘communitarian’, and ‘nationalist’ politics of the interwar era. In doing so, it sketches an era of political possibilities that later gave way to a bitterly contested and fractured landscape with hardened political and ideological boundaries.
The third chapter, ‘Break with the Old World’ uses memoirs, intelligence accounts, and hitherto unused sources from the Comintern archives, to follow the journeys of Indian revolutionaries to and through Moscow. For revolutionaries from the colonized world, Moscow offered support, sustenance, and a vision for a liberated future. It was also a site of wonder and amazement, where a new world and a new human was being inaugurated. For those who learnt their communism in the Soviet Union, Moscow was both a physical embodiment of a break with History and a vision of a utopic world within reach. Through the lifeworlds (Lebenswelt) of ‘Moscow graduates’, I trace the history of the varied and multilayered engagements between the Communist International (Comintern) and communist groups in India from the heady and millenarian days of the Leninist moment to its calamitous Stalinist successor.
The second chapter, ‘Travellers, Migrants, Rebels’, traces Indian networks that forged a radical anti-imperialist politics in the diaspora. These networks later fed into the development and evolution of the leftist movement in British India. Through the lives of key figures, I trace how networks of radicalism emerged and thrived in the global arena. Along with networks of labourers, migrants, and lascars, I focus primarily on the Ghadar and the Khilafat movements. Through these circuits and the figures involved in them, I sketch how an itinerant life provided a foray into revolutionary politics and was in turn intimately connected to a revolutionary ethic. In doing so, I also examine an oft-neglected question of how political radicalism was deeply wedded to distinct spaces and spatial imaginaries. In tracing how ideas and lived experiences – and thereby intellectual and social histories – were co-constitutive of each other, I chart the antecedents of the communist movement in British India.
The next chapter, ‘This Time Is Ours’, looks at a regional expression of leftist politics. I examine how the politics and ethics of communist internationalism acquired a distinctly regional flavour through a case study of the Kirti Kisan Party and its successors in the Punjab. Partly financed, supported, and constituted by the Ghadar Party, the Kirti Party was the most prominent communist network in British Punjab. Alongside the Communist Party of India (CPI), it was also the only communist group in India to have direct relations with the Comintern. Not only is this chapter an attempt to move beyond CPI-centred histories of the Left, it is also an examination of how intimately communism was woven in with localized idioms. At the same time, it is also a reminder of how deeply local politics was tied to global developments and the politics of Communist Internationalism. In tracing this trajectory, I explore what communism meant to those involved in it. I also explore the kinds of ethical subjects inaugurated, in person as much as in imagination, by the communist movement in India.
In the Epilogue, ‘Utopias Lost’, I provide a brief overview of what decolonization and ‘independence’ meant for a partitioned Left on both sides of the Radcliffe line. For many, not much had changed. If anything, both post-colonial states persecuted communists with an equal, if not greater, alacrity than their colonial predecessor. The freedom that had been attained was not the freedom that many had imagined and fought for. This was the starting point for communist politics in both India and Pakistan. Using the communists’ social–economic, political, and ethical conceptions of a post-imperial and post-national azadi (freedom), I ask what revolutionary pasts have to offer us in our present moment when the spectre of parochial and exclusionary nationalism seems to be on the ascendant in South Asia and beyond. At the very least, I argue, a history of the Left encourages a re-envisioning of ethical possibilities and subjectivities in modern South Asia. In doing so, the Left also provides a salutary reminder of how it was, and still is, an essential and integral part of the cultural, social, and political fabric of South Asia. As Overstreet and Windmiller argued in Communism in India, no understanding of Indian history since the First World War is possible without an examination of the communist movement and its relation to world communism and Indian nationalism.
The sixth chapter, ‘Red Scare’, examines how the British Raj dealt with the communist threat. Viewed merely as a proxy of the Soviet Union, communist movements were relentlessly persecuted by the state. In an examination of the colonial state’s evolving response to the communist movement through an analysis of ‘conspiracy cases’ and other legislative, executive, and coercive mechanisms, I trace how the colonial state was instrumental in casting ‘communism’ and leftist politics in the subcontinent as essentially alien to India. Central to this argument was the way that ‘communism’ had been imagined by the state. Viewed from its very inception as ‘unnatural’ and ‘foreign’, and frequently likened to a ‘virus’ that could spread controllably if left unchecked, the state’s approach to communism provides significant insights into not just the nature of the state but also how it viewed the Indian political sphere. More importantly, it also shows how the state’s arguments were later appropriated by the nationalist movement and other forces inimical to the Left to delegitimize the latter’s politics. I argue that it was the Colonial State that was instrumental in fracturing the Left and its alliances with the other political movements. This explained in large measure how the Left came to be excised from histories of national liberation.