Although individuals born at extremely low birth weight (ELBW; ≤1000 g) are known to be at greater risk for mental health problems than individuals born at normal birth weight (NBW; ≥2500 g), contributions of postnatal growth to these relations have not been fully explored. We compared individual differences in the Ponderal Index [(PI; weight(kg)/height(m3)] and head circumference (HC) in predicting internalizing and externalizing behaviors in childhood and adolescence in a cohort of ELBW survivors (N = 137) prospectively followed since birth. Baseline models indicated that infants who were born thinner or with smaller HC showed greater PI or HC growth in the first 3 years. Latent difference score (LDS) models showed that compensatory HC growth in the first year (ΔHC = 20.72 cm), controlled for birth HC, predicted ADHD behaviors in adolescence in those born with smaller HC. LDS models also indicated that the PI increased within the first year (ΔPI = 1.568) but decreased overall between birth and age 3 years (net ΔPI = −4.597). Modeling further showed that larger increases in the PI in the first year and smaller net decreases over 3 years predicted more internalizing behaviors in adolescence. These findings suggest early growth patterns prioritizing weight over height may have negative effects on later mental health in ELBW survivors, consistent with developmental programming theories.

Background: We aim to assess the role of quantitative electroencephalography (QEEG) derived indices to predict post-stroke disability. Methods: We included observational studies (sample-size≥10) of patients with stroke who underwent EEG and a follow-up outcome assessment was available either in form of a modified Rankin scale (mRS) or National Institute of stroke scale (NIHSS) or Fugl-Meyer scale (FMA). QEEG indices analyzed were delta-alpha ratio (DAR), delta-theta-alpha-beta ratio (DTABR), brain symmetry (BSI) and pairwise derived brain symmetry (pdBSI). Results: Twelve studies (11 had only ischemic stroke, and one had both ischemic and hemorrhagic stroke), including 513 participants were included for meta-analysis. Higher DAR was associated with worse mRS (n=300, Pearson’s r 0.26, 95% CI 0.21-0.31). Higher DTABR was associated with worse mRS (n=337, r 0.32, 95% CI 0.26-0.39). Higher DAR was associated with higher NIHSS (n=161, r 0.42, 95% CI0.24-0.6). Higher DTABR was associated with higher NIHSS (n=172, r 0.49, 95% CI 0.31-0.67). pdBSI was inversely associated with FMA (n=20, r-0.50 95% CI -0.86-(-0.14)) and BSI was not associated with FMA (n=21, r -0.3 95% CI -0.81-0.22). Conclusions: QEEG-derived indices have the potential to assess post-stroke disability. Adding QEEG to the clinical and imaging biomarkers may help in better prediction of post-stroke recovery.

PROSPERO 2022 CRD42022292281

The Royal Asiatic Society in London houses a collection of magic lantern slides of China dating from the late nineteenth and early twentieth centuries. By investigating a selection of lantern slides, this article explores their epistemological nature and their wider relations to socio-cultural and political systems of power. These lantern slides highlight the complexity of our ways of seeing and representing that are embedded into particular historical and ideological systems in which meaning is both shaped and negotiated. This article argues that images are powerful conduits in disseminating and, if unchallenged, maintaining particular notions and ideas.

Effects of stresses associated with extremely preterm birth may be biologically “recorded” in the genomes of individuals born preterm via changes in DNA methylation (DNAm) patterns. Genome-wide DNAm profiles were examined in buccal epithelial cells from 45 adults born at extremely low birth weight (ELBW; ≤1000 g) in the oldest known cohort of prospectively followed ELBW survivors (Mage = 32.35 years, 17 male), and 47 normal birth weight (NBW; ≥2500 g) control adults (Mage = 32.43 years, 20 male). Sex differences in DNAm profiles were found in both birth weight groups, but they were greatly enhanced in the ELBW group (77,895 loci) versus the NBW group (3,424 loci), suggesting synergistic effects of extreme prenatal adversity and sex on adult DNAm profiles. In men, DNAm profiles differed by birth weight group at 1,354 loci on 694 unique genes. Only two loci on two genes distinguished between ELBW and NBW women. Gene ontology (GO) and network analyses indicated that loci differentiating between ELBW and NBW men were abundant in genes within biological pathways related to neuronal development, synaptic transportation, metabolic regulation, and cellular regulation. Findings suggest increased sensitivity of males to long-term epigenetic effects of extremely preterm birth. Group differences are discussed in relation to particular gene functions.

Extremely low birth weight (ELBW; <1000 g) infants have been exposed to stressful intrauterine and early postnatal environments. Even greater early adversity has been experienced by ELBW survivors who were also born small for gestational age (SGA; <10th percentile for GA) compared to those born appropriate for GA (AGA). ELBW survivors, particularly those born SGA, face increased risk for internalizing problems compared to normal BW (NBW; ≥2500 g) controls. Internalizing problems are related to allelic variations in the promoter region of the serotonin transporter linked polymorphic region gene (5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology.

Over a period of one year from March 1967, the 24-inch rotatable telescope at Siding Spring Observatory was used to make polarization measurements for about 1400 stars, most of which were within 400 pc of the Sun. It was found that the E vectors of the polarization formed quite definite patterns on the sky which could only be produced if the magnetic field has a helical structure. Results of model-making showed that the magnetic lines of force form tightly wound right-handed helices of pitch angle 7°. They lie on the surface of tubes which have elliptical cross-sections of axial-ratio 3 with semi-major axes parallel to the galactic plane.

Results of recent surveys of high velocity HI clouds with the 80-ft reflector at Dwingeloo and with the 260-ft x 80-ft standing paraboloid of the Ohio State University are combined. They show that clouds with high negative radial velocities occur mainly in the longitude range 50° to 220° from N. to S. galactic poles. However, nearly three times as many clouds are found north than south of the galactic plane. Clouds with high positive radial velocities are much less numerous than the negative velocity clouds. They have been found between longitudes 260° to 350° and scattered around lII = 75°, bII = +45°.

This review concentrates on observations of neutral hydrogen in the Magellanic System, and what they reveal about the structure, dynamics, evolution and ultimate fate of the LMC and SMC. Some recent observations of 161 Cepheid variables in the SMC are used together with the HI observations to determine the geometry of the SMC. These show that it has an amazing depth of at least 30 kpc. To explain the results it is proposed that the SMC had a close encounter with the LMC which has warped the disk of the LMC, produced the bridge between the two galaxies and tidally fissioned the SMC. The SMC is in the process of irreversible disintegration. It is believed that the Magellanic Clouds are not bound to our Galaxy and approached us from the direction of Andromeda. They may have had a close encounter with Andromeda 3 x 109 years ago, which may explain the massive starburst which occurred in the LMC and SMC at that time. It is believed that the Magellanic Stream has been swept out of the inter-Cloud region by the ram pressure of the gaseous halo of our Galaxy. If dynamic friction is sufficient for the Clouds to be captured and to eventually collide with our Galaxy, a polar ring will be formed similar to that observed in some other galaxies. The polar ring of dwarf spheroidals and outlying globular clusters at present encircling our Galaxy may be the remnants of a previous collision with some other galaxy 6 x 109 years ago.

It is believed that the splitting of the SMC into two fragments and the production of the Inter-Cloud gas and the Magellanic Stream occurred in the one event 4 × 108 years ago. This event was a collision between the LMC and SMC. This time is too short for the Stream to be tidal, or be the result of stripping of the Inter-Cloud gas by a diffuse gaseous halo. It is proposed that the clouds in the Stream are the results of collisions between the Inter-Cloud gas and HVCs in the Galactic halo. A model of this process accounts for all of the observational features of the Stream. Observations of HVCs in the path of the Magellanic Clouds are used to predict the development of the Stream. The HVCs in our halo are thought to be a result of a collision of a galaxy with our Galaxy 6 × 109 years ago.

New observations of the Magellanic Stream were made in December 1976 with the 64-m radio telescope at the Parkes Observatory of CSIRO. The ridges of H I emission of the Stream were traced from near its tip at ℓ = 90°, b = -40° to the Magellanic Clouds. This was the first time that the total length of the Stream was observed with the one system (only possible from the southern hemisphere) and with high spatial (15’ of arc) and velocity (4 km s-1) resolution. The results of this survey are presented in Figures 1 and 2 and the main features are listed below.

This document is the final Phase A Science Report of the Australian LYMAN Science Working Group, and describes in detail the scientific objectives, technical feasibility, and engineering implementation of the LYMAN mission as developed in the Australian studies.

I shall briefly outline some observational aspects of the Magellanic Stream before discussing the pros and cons of the two conflicting theories of its origin: a) that the Stream was pulled out of the Clouds by tidal forces produced by a close encounter with our Galaxy and b) that the gas clouds of the Stream are primordial and in the same orbit as theMagellanic Clouds.

The initial results of a southern sky survey of the peculiar velocities of 1355 spiral galaxies by a group at Mount Stromlo and Siding Spring Observatories (MSSSO) are discussed against the background of past work in this area. The most important result is that the Great Attractor does not exist; rather, there is bulk flow relative to the cosmic microwave background (CMB) of amplitude 600 km s−1 and scale greater than 130 h−1 Mpc in the Supergalactic plane. This is generated by the assumption that the CMB dipole is Doppler induced by our Galaxy moving at 622 km s−1 relative to the CMB. This may be incorrect, in which case there is no bulk flow and the radiation dipole is cosmological in origin with important implications for the early Universe.

Studies on reproduction in a colony of albino mice before and after length of daylight was made constant show no change in litter size. However, there was an increase in the number of post-partum pregnancies after light was made constant and, during the first month thereafter, females were older at first parturition than in previous months.

The complex pathogen–host–vector system of the tick-borne louping-ill virus causes economic losses to sheep and red grouse in upland United Kingdom. This paper examines the spatial distribution, incidence and effect of control measures on louping-ill virus in the Bowland Fells of Lancashire. Seroprevalence in sheep at the beginning of the study varied within the area and was affected significantly by the frequency of acaricide treatment. There was a clear decrease over 5 years in the effective force of infection on farms implementing a vaccination programme, irrespective of acaricide treatment regime, however, only one third of farms apparently eliminated infection. On farms where vaccination did not occur or where vaccination was carried out intermittently, the estimated force of infection was variable or possibly increased. Thus, as befits a complex host–pathogen system, reductions in prevalence were not as dramatic as predicted; we discuss the potential explanations for these observations.