Exploring space is one of the most attractive goals that humanity ever set, notwithstanding, there are some psychological and psychopathological risks that should be considered. Several studies identified some possible hazards of space travels and related physical and psychological consequences on astronauts. If some psychological reactions are obviously inherent to the characteristics of the spaceships (habitability, confinement, psychological, and interpersonal relationships), other (disturbances of sleep-wake cycle, personality changes, depression, anxiety, apathy, psychosomatic symptoms, neurovestibular problems, alterations in cognitive function, and sensory perception) represent a clear warning of possible central nervous system (CNS) alterations, possibly due to microgravity and cosmic radiation. Such conditions and eventual CNS changes might compromise the success of missions and the ability to cope with unexpected events and may lead to individual and long-term impairments. Therefore, further studies are needed, perhaps, requiring the birth of a novel branch of psychology/psychiatry that should not only consider the risks related to space exploration, but the implementation of targeted strategies to prevent them.

Background: Post-stroke depression (PSD) is the most frequent psychiatric complication following ischemic stroke. It affects up to 60% of all patients and is associated with increased morbidity and mortality following ischemic stroke. The pathophysiology of PSD remains elusive and appears to be multifactorial, rather than “purely” biological or psychosocial in origin. Thus, valid animal models of PSD would contribute to the study of the etiology (and treatment) of this disorder. Methods: The present study depicts a rat model for PSD, using middle cerebral artery occlusion (MCAO). The two-way shuttle avoidance task, Porsolt forced-swim test, and sucrose preference test were employed to assess any depression-like behavior. Localized brain expressions of brain-derived neurotrophic factor (BDNF) protein levels were evaluated to examine the possible involvement of the brain neuronal plasticity in the observed behavioral syndrome. The raw data were subjected to unsupervised fuzzy clustering (UFC) algorithms to assess the sensitivity of bio-behavioral measures indicative of depressive symptoms post MCAO. Results: About 56% of the rats developed significant depressive-like behavioral disruptions as a result of MCAO compared with 4% in the sham-operated control rats. A pattern of a depressive-like behavioral response was common to all affected MCAO animals, characterized by significantly more escape failures and reduced number of total avoidance shuttles, a significant elevation in immobility duration, and reduced sucrose preference. Significant downregulations of BDNF protein levels in the hippocampal sub-regions, frontal cortex, and hypothalamus were observed in all affected MCAO animals. Conclusion: The UFC analysis supports the behavioral analysis and thus, lends validity to our results.

The world's natural freshwater resources available for human use are more scarce than is generally assumed. This statement has already become a cliche, yet the truth it reveals is getting more apparent every day, just as is the case with other global problems which require solutions above and beyond the parochial and short term interests of individual nation states. Water scarcity has two important aspects, both with political connotations at different levels, with worldwide maldistribution of economic and natural resources being at the core of the problem.

In this paper we consider a class of single-server queueing systems with compound Poisson arrivals, in which, at service completion epochs, the server has the option of taking off for one or several vacations of random length. The cost structure consists of a holding cost rate specified by a general non-decreasing function of the queue size, fixed costs for initiating and terminating service, and a variable operating cost incurred for each unit of time that the system is in operation. We show under some weak conditions with respect to the holding cost rate function and the service time, vacation time and arrival batch size distributions that it is either optimal among all feasible (stationary and non-stationary) policies never to take a vacation, or it is optimal to take a vacation when the system empties out and to resume work when, upon completion of a vacation, the queue size is equal to or in excess of a critical threshold. These optimality results are generalized for several variants of this model.

We consider a single-server queueing system with Poisson arrivals and general service times. While the server is up, it is subject to breakdowns according to a Poisson process. When the server breaks down, we may either repair the server immediately or postpone the repair until some future point in time. The operating costs of the system include customer holding costs, repair costs and running costs. The objective is to find a corrective maintenance policy which minimizes the long-run average operating costs of the system. The problem is formulated as a semi-Markov decision process. Under some mild conditions on the repair time and service time distributions and the customer holding cost rate function, we prove that there exists an optimal stationary policy which is characterized by a single threshold parameter: a repair is initiated if and only if the number of customers in the system exceeds this threshold. We also show how the average cost under such policies may be computed and how an optimal policy may efficiently be determined.

Manuscript libraries, the items collected in them, their location, and something of their history can be classified as follows (previous work on this subject was described in Lütfü Eroğiu’s “Istanbul Kütüphaneleri”):

1. 1. Ministry of Culture and Tourism’s libraries under the auspices of the General Directorate of Libraries.

2. 2. Ministry of Culture and Tourism’s libraries under the auspices of the General Directorate of Monuments and Museums.

3. 3. University libraries.

4. 4. Public libraries.

5. 5. Libraries under the auspices of the General Directorate of Foundations.

6. 6. Private libraries, such as those associated with banks or newspapers.