Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

44 results

Page 1 of 3

  • Relationship between CAINS negative symptoms and cognition, psychosocial functioning and quality of life in patients with a first psychotic episode of schizophrenia

  • R. Rodriguez-Jimenez, L. García-Fernández, V. Romero-Ferreiro, M. Valtueña García, A. I. Aparicio, J. M. Espejo-Saavedra, L. Sánchez-Pastor, A. Nuñez-Doyle, M. Dompablo, O. Jiménez-Rodríguez, D. Rentero, P. Fernández-Sotos, I. Martínez-Gras, J. L. Santos
  • Journal:
    European Psychiatry / Volume 66 / Issue S1 / March 2023
    Published online by Cambridge University Press:
    19 July 2023, pp. S641-S642
    • Article
      • You have access
      • Open access
    • PDF
    • Export citation
  • Introduction

    Negative symptoms has been classically associated with cognition, psychosocial functioning and quality of life in patients with schizophrenia. But negative symptoms are not a unitary construct, encompassing two different factors: diminished expression, and motivation and pleasure. Few works have studied the relationship between these two different negative symptoms factors and cognition (neuro and social cognition), psychosocial functioning and quality of life, jointly, in patients with a first psychotic episode of schizophrenia.

    Objectives

    The objective of the present work was to study, in a sample of patients with a first psychotic episode of schizophrenia, the relationship between the negative symptoms (diminished expression and motivation and pleasure) and neurocognition, social cognition, functioning and quality of life.

    Methods

    The study was carried out with 82 outpatients with a first psychotic episode of schizophrenia from two Spanish hospitals (“12 de Octubre” University Hospital, Madrid and “Virgen de la Luz” Hospital, Cuenca). The patients were assessed with the Clinical Assessment Interview for Negative Symptoms (CAINS) for evaluating diminished expression (EXP) and motivation and pleasure (MAP) symptoms, the MATRICS Consensus Cognitive Battery (MCCB) for evaluating neurocognition and social cognition, the Social and Occupational Functioning Assessment Scale (SOFAS), and the Quality of Life Scale (QLS).

    Results

    A negative correlation was found between neurocognition and the two negative symptoms subscales: CAINS-EXP (r=-0.458, p<0.001) and CAINS-MAP (r=-0.374, p<0.001); but with social cognition only CAINS-EXP was correlated (r=-0.236, p=0.033). Also, it was found a high negative correlation between SOFAS scores and CAINS-MAP (r=-0.717, p<0.001); and a medium negative correlation with CAINS-EXP (r=-0.394, p<0.001). Finally, QLS score was high correlated with both CAINS subscales: CAINS-EXP (r=-0.681, p<0.001) and CAINS-MAP (r=-0.770, p<0.001).

    Conclusions

    This study found a relationship between negative symptoms and neurocognition, social cognition, functioning and quality of life in a sample of patients with a first psychotic episode of schizophrenia. But the two different negative symptom factors, diminished expression, and motivation and pleasure, are associated differently with psychosocial functioning, but especially with social cognition where the relationship was only found with diminished expression symptoms.

    Disclosure of Interest

    None Declared

  • P.204 Integration of patient directed approach in pituitary tumor management – The Ottawa Hospital experience

  • I Druce, M Doyle, A Arnaout, C Agbi, E Keely, J Malcolm, F Alkherayf
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 48 / Issue s3 / November 2021
    Published online by Cambridge University Press:
    05 January 2022, p. S78
    • Article
      • You have access
    • PDF
    • Export citation

  • Background: Pituitary adenomas are common and often require complex multidisciplinary care with multiple specialists. This may result in a health care system that is challenging for patients to navigate. Audits of care at our institution revealed opportunities for improvement to better align care with patients’ needs. Methods: A quality improvement initiative that incorporated a patient advisory committee of patients who had received treatment for pituitary adenoma at our center and their family members was used to help identify opportunities for improvement. The patient-identified gaps in care included the need to coordinate and minimize appointments and the desire for better communication and education. Based on this information, changes were implemented to the pituitary program, including increasing access to the multidisciplinary clinic and developing a standardized and centralized triage process. Results: A pre and post-intervention analysis consisting of retrospective chart reviews revealed that these changes had an impact on wait times for first assessment, and a significant shift in location of this first visit – with a larger proportion of patients being seen in the multidisciplinary clinic after intervention. Conclusions: We demonstrate that patient involvement, beyond individual patient-physician interactions, can lead to meaningful and observable changes, and can improve the quality of care for pituitary adenoma.

  • The Doyle–Saleh blink reflex

  • P W Doyle, I Beegun, H A Saleh
  • Journal:
    The Journal of Laryngology & Otology / Volume 131 / Issue 4 / April 2017
    Published online by Cambridge University Press:
    23 January 2017, pp. 347-349
    Print publication:
    April 2017
  • Objectives:

    When performing septoplasty or septorhinoplasty, we have observed that patients blink on injection of local anaesthetic (lidocaine 1 per cent with adrenaline 1:80 000) into the nasal mucosa of the anterior septum or vestibular skin, despite appropriate general anaesthesia. This study sought to quantify this phenomenon by conducting a prospective audit of all patients undergoing septoplasty or septorhinoplasty.

    Methods:

    Patients were observed for a blink reflex at the time of local anaesthetic infiltration into the nasal vestibule. Also measured at this point were propofol target-controlled infusion levels, remifentanil rate, bispectral index, blood pressure, heart rate, pupil size and position, and patient movement.

    Results:

    There were 15 blink reflexes in the 30 patients observed. The average bispectral index value was 32.75 (range, 22–50) in the blink group and 26.77 (range, 18–49) in the non-blink group. No patients moved on local anaesthetic injection.

    Conclusion:

    The blink reflex appears to occur in 50 per cent of patients, despite a deep level of anaesthesia. Without an understanding and appreciation of the blink reflex, this event may result in a request to deepen anaesthesia, but this is not necessary and surgery can proceed safely.

  • Preface

  • Edited by Carol M. Meale, Senior Research Fellow at the University of Bristol, Derek Pearsall, Professor Emeritus at Harvard University and Honorary Research Professor at the University of York
  • Book:
    Makers and Users of Medieval Books
    Published by:
    Boydell & Brewer
    Published online:
    05 May 2014
    Print publication:
    17 July 2014, pp xi-xiv

  • Summary

    We must begin with names. ‘Tony Edwards’ is the person to whom this volume is dedicated, but it is not a name that everyone will immediately recognize, particularly those who know him only from his published work, for he has made himself known in public, from the first, as A. S. G. Edwards. When he began his career, this was the manner in which most scholars, most men at least, named themselves. Fashions have changed, and given names, one, two, or more, are now almost universal. But Tony has held on tenaciously to his initials, perhaps because he has three of them. We do not believe that he did so in any spirit of emulation of or desire to align himself with ‘Edwards A. S. G.’, the Edwards Active Strain Gauge well known to Google, an advanced form of technical engineering equipment which guarantees the vacuum conditions needed for the manufacture of certain precision instruments, such as aircraft engine turbine blades. It seems strangely apt as an analogous form of ‘A. S. G.’, whether one thinks of the ‘active strain’ involved as what he exerts upon himself or upon other people. The analogy fails, of course, when one comes to the creation of vacuum, where it works back to front, for Tony's work has essentially been to fill the vacuum that once existed in the study of manuscript history.

Makers and Users of Medieval Books
  • Essays in Honour of A.S.G. Edwards
  • Edited by Carol M. Meale, Derek Pearsall
  • Published by:
    Boydell & Brewer
    Published online:
    05 May 2014
    Print publication:
    17 July 2014
  • Late medieval manuscripts and early modern print history form the focus of this volume. It includes new work on the compilation of some important medieval manuscript miscellanies and major studies of merchant patronage and of a newly revealed woman patron, alongside explorations of medieval texts and the post-medieval reception history of Langland, Chaucer and Nicholas Love. It thus pays a fitting tribute to the career of Professor A.S.G. Edwards, highlighting his scholarly interests and demonstrating the influence of his achievements. Carol M. Meale is Senior Research Fellow at the University of Bristol; Derek Pearsall is Professor Emeritus at Harvard University and Honorary Research Professor at the University of York. Contributors: Nicolas Barker, J.A. Burrow, A.I. Doyle, Martha W. Driver, Susanna Fein, Jane Griffiths, Lotte Hellinga, Alfred Hiatt, Simon Horobin, Richard Linenthal,Carol M. Meale, Orietta Da Rold, John Scattergood, Kathleen L. Scott, Toshiyuki Takamiya., John J. Thompson.

Page 1 of 3