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In the frame of the IAEA-CRP (Coordinated Research Projects): Enhancing Nuclear Analytical Techniques to Meet the Needs of Forensic Sciences, an intercomparison exercise was organized between three AMS laboratories. Aim of the program is to promote the use of nuclear and accelerator-based techniques in routine forensics practice. In this view, one of the key points is the assessment of the precision and accuracy levels achievable on material of forensic interest. We review the general structure and status of the project, with emphasis on results obtained in the analysis of wines of different grape varieties and grounded coffee beans from different locations such as Brazil, Spain, and Italy. The three laboratories processed the samples according to different chemical protocols and performed the 14C measurements using different systems: MICADAS in Zurich and Debrecen and a HVEE 4130HC 3 MV Tandetron in Lecce. Within the quoted uncertainty, the results showed good reproducibility, indicating that uncertainty level of the order of 0.3% are achieved by AMS on a single sample while multiple sample analyses results in precision down to 0.1–0.2%. The measured 14C concentrations on coffee and wine samples resulted to be consistent with atmospheric 14C levels in the growing years.
OBJECTIVES/GOALS: Despite a disproportionate impact of COVID-19 on minority and under-resourced communities, nearly all COVID-19 resources have only been online in English. A statewide coalition of community and academic partners used community-engaged strategies to provide tailored outreach to diverse populations. METHODS/STUDY POPULATION: The STOP COVID-19 CA statewide team had a workgroup focused on communications. Members of this group represented different sectors, racial/ethnic groups, disciplines, and regions across the state. They had regular meetings to discuss and strategize how to overcome the impact of historic and structural racism on access to COVID-19 resources, including testing, vaccines, and protective equipment. The team also shared regular updates about changes in community concerns and needs as well as new, tailored resources. RESULTS/ANTICIPATED RESULTS: Together, the team has been able to reach diverse populations across the state, including providing information about COVID-19 in multiple languages and formats, from radio to virtual town halls to local health fairs. The multiple sites also increased access to vaccines and testing through trusted community leaders and locations, including church-based locations to bringing vaccines and testing directly to workplaces. These community pop-up vaccination sites have helped to vaccinate large numbers of diverse populations, some of whom were initially unsure about getting the vaccine, which has helped to reduce the gaps in community vaccination rates by race/ethnicity. DISCUSSION/SIGNIFICANCE: This network of community-engaged strategies utilized for rapid COVID-19 response could also be used to for responses to future public health emergencies, addressing chronic diseases (e.g., diabetes, hypertension), or even other complex issues that affect society and health (e.g., climate change).
In this work, a semianalytic solution for the acoustic streaming phenomenon, generated by standing waves in Maxwell fluids through a two-dimensional microchannel (resonator), is derived. The mathematical model is non-dimensionalized and several dimensionless parameters that characterize the phenomenon arise: the ratio between the oscillation amplitude of the resonator and the half-wavelength ($\eta =2A/\lambda _{a}$); the product of the fluid relaxation time times the angular frequency known as the Deborah number ($De=\lambda _{1}\omega$); the aspect ratio between the microchannel height and the wavelength ($\epsilon =2 H_{0}/\lambda _{a}$); and the ratio between half the height of the microchannel and the thickness of the viscous boundary layer ($\alpha =H_{0}/\delta _{\nu }$). In the limit when $\eta \ll 1$, we obtain the hydrodynamic behaviour of the system using a regular perturbation method. In the present work, we show that the acoustic streaming speed is proportional to $\alpha ^{2.65}De^{1.9}$, and the acoustic pressure varies as $\alpha ^{6/5}De^{1/2}$. Also, we have found that the growth of inner vortex is due to convective terms in the Maxwell rheological equation. Furthermore, the velocity antinodes show a high dependency on the Deborah number, highlighting the fluid's viscoelastic properties and the appearance of resonance points. Due to the limitations of perturbation methods, we will only analyse narrow microchannels.
The National Institute of Mental Health's Research Domain Criteria (RDoC) framework has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally based tools for clinical decision making has limited the real-world impact of the RDoC. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between the RDoC multiple units of analysis and developmental science.
A laboratory intercomparison project was carried out on 20 annually resolved late-wood samples from the Danish oak record. The project included the following three laboratories: (1) the University of Arizona AMS Laboratory, University of Arizona, USA (AA); (2) HEKAL AMS Laboratory, MTA Atomki, Hungary (DeA); and (3) Aarhus AMS Centre (AARAMS), Aarhus University, Denmark (AAR). The large majority of individual data points (96%) lie within ±2σ of the weighted mean. Further assessment of the accuracy associated with the individual laboratories showed good agreement, indicating that consistent and reliable 14C measurements well in agreement with each other are produced at the three laboratories. However, the quoted analytical uncertainties appear to be underestimated when compared to the observed variance of differences from the geometric mean of the samples. This study provides a general quality check of the single-year tree-ring 14C measurements that are included in the new calibration curve.
Migration is a highly defining life event which can lead to mental distress. It constitutes an overall risk factor for psychiatric disorders. However, psychotherapeutic treatment in immigrant patients is considered to be more complex, and the outcome appears to be less favorable than in patients without a migration background.
Objectives
The aim of this study is to compare psychotherapy assessment between immigrant and non-immigrant psychotic patients in Barcelona.
Methods
Patients who have presented, according DSM-V criteria, one or more non-affective psychotic episodes, were recruited in Acute and Chronic inpatients units at Hospital del Mar (Barcelona), leading to a total sample of 77 patients. Demographic characteristics of patients, clinical data and main pharmacological treatment were recorded through a questionnaire. Database information was completed with electronic medical records. Comparative analysis was performed with IBM SPSS using Chi-Square and t-Student test
Results
From a total of 77 patients, 43 were immigrants and 34 were non-immigrants. From the total immigrants only 30,2% received psychotherapy compared to 79,4% from the non-immigrants. The most prevalent therapy received in both groups was cognitive behavioural therapy. From the immigrants group only 2,3% received psychoeducation compared to 11,8% from the non-immigrant group.
Conclusions
According to our results, there are important and significant differences in psychotherapy assessment in migrant psychotic patients. In order to improve the mental health treatment of immigrant patients, the reasons for this poor outcome need to be investigated. These results should be considered by clinicians in order to design assessment program for this population.
Meta-analytic evidence suggests that migrants have higher risk for psychotic disorders. Likewise, growing evidence relate developmental trauma (emotional, sexual, physical abuse and neglect in childhood or adolescence) as a causal factor for psychotic symptoms. However, few studies examine developmental trauma in migrant populations.
Objectives
The aim of this study is to describe and compare developmental trauma exposure prevalence between immigrant and non-immigrant psychotic patients in Barcelona.
Methods
Patients who have presented, according DSM-V criteria, one or more non-affective psychotic episodes, were recruited in Acute and Chronic inpatients units at Hospital del Mar (Barcelona), leading to a total sample of 77 patients. Demographic characteristics of patients, clinical data and main pharmacological treatment were recorded through a questionnaire. Developmental trauma exposure was assessed by Childhood Trauma Questionnaire (CTQ). Comparative analysis was performed with IBM SPSS using Chi-Square Test and t-Student test.
Results
From a total of 77 patients, 43 were immigrants and 34 were non-immigrants. Exposure to traumatic events showed significant differences between immigrants and non-immigrant in Child emotional abuse (64,4% immigrants, 35,3% non-immigrant), Child physical abuse (51,2% immigrants, 14,7% non-immigrant), Child Sexual Abuse (41,9% immigrants, 11,8% non-immigrant) and physical neglect (62,8% immigrants, 26,5% non-immigrant). Emotional neglect exposure was no significant between both groups. Total mean CTQ score was 37,53 in immigrants group and 52,60 in non-immigrant group.
Conclusions
According to our results, there are important and significant differences in developmental trauma exposure between immigrant and non-immigrant psychotic patients. These results should be considered by clinicians in order to design assessment program for this population.
Adolescents living with HIV (ALWH) are disproportionally impacted by depression, experiencing worse HIV outcomes. Integrated depression and HIV care may support antiretroviral adherence. This study pilot tested for proof of concept a basic depression care pathway for ALWH to inform depression care integration with HIV services in Peru.
Methods
ALWH were screened for depression with the Patient Health Questionnaire-9 (PHQ-9). Participants with PHQ-9 scores of ⩾10 or suicidal ideation (SI) were eligible for Psychological First Aid (PFA) delivered by non-mental health specialists. Participants with PHQ-9 re-assessments of ⩾20 or SI were referred to specialized services.
Results
Twenty-eight (11 female, 17 male) ALWH aged 15–21 years participated; n = 20 (71%) identified as heterosexual. Most (18/28) acquired HIV at birth. Baseline PHQ-9 scores were 0–4, n = 3 (11%); 5–9, n = 9 (32%); 10–14, n = 10 (36%); 15–19, n = 4 (14%); and 20–27, n = 2 (7%). Eleven participants (40%) reported SI. Among participants with PHQ-9 > 4, 92% (23/25) were not severe. Of the 21 (75%) of participants eligible for PFA, n = 9 (32%) accepted at least one session, of which n = 3 (33%) were linked to specialized care.
Conclusions
A simple care pathway operationalizing depression screening and non-specialist delivered emotional support is a first step toward integrated depression and HIV care for ALWH.
Previous research has shown that individuals suffering from depression and generalized anxiety disorder (GAD) seem to have inhibitory control deficits compared with healthy controls. However, few studies have been conducted in Spanish-speaking countries. Thus, this study aims to analyze the performance on the Stroop Color and Word Test (SCWT) between groups of Colombian participants with clinical levels of depression and GAD symptoms and a nonclinical control group. According to previous research, we expected to find significant differences in inhibitory control among groups. An ex post facto design was implemented. The SCWT was administered to a total sample of 105 individuals (64.8% women, M = 22.94 years, SD = 4.62), including 27 depressed and 15 anxious participants according to their scores on the Personal Health Questionnaire–9 and the Generalized Anxiety Disorder–7, respectively. Bayesian t-tests showed that depressed participants showed the same processing speed but lower scores on inhibitory control than healthy controls, BF = 13.70, δ = 0.50, 95% CI [0.08, 0.94]. Conversely, anxious participants showed deficits in processing speed, SCWT-Word: BF = 16.19, δ = 0.68, 95% CI [0.15, 1.24]; SCWT-Color: BF = 5.98, δ = 0.50, 95% CI [–0.01, 1.04], but not in inhibitory control compared with the nonanxious counterparts. This study provides preliminary evidence concerning the inhibitory control deficits in Colombian depressed individuals and processing speed deficits in those experiencing clinical levels of GAD symptoms.
Let C be a hyperelliptic curve of genus
$g \geq 3$
. In this paper, we give a new geometric description of the theta map for moduli spaces of rank 2 semistable vector bundles on C with trivial determinant. In order to do this, we describe a fibration of (a birational model of) the moduli space, whose fibers are GIT quotients
$(\mathbb {P}^1)^{2g}//\text {PGL(2)}$
. Then, we identify the restriction of the theta map to these GIT quotients with some explicit degree 2 osculating projection. As a corollary of this construction, we obtain a birational inclusion of a fibration in Kummer
$(g-1)$
-varieties over
$\mathbb {P}^g$
inside the ramification locus of the theta map.
Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.
Annually resolved radiocarbon (14C) measurements on tree rings led to the discovery of abrupt variations in 14C production attributed to large solar flares. We present new results of annual and subannual 14C fluctuations in tree rings from a middle-latitude sequoia (California) and a high-latitude pine (Finland), analyzed for the period 1030–1080 CE, to trace a possible impact of the Crab supernova explosion, occurring during the Oort minimum of solar activity. Our results indicate an increase of Δ14C around 1054/55 CE, which we estimate is higher in magnitude than the cyclic variability due to solar activity at a 2σ significance level. The net signal appears to be synchronized in the studied locations. Several sources of this event are possible including γ-rays from the Crab supernova, an unusually weak solar minimum or a solar energetic particle incident. More data are needed to provide more insight into the origin of this 14C event.
This work presents updates in the diagnostics systems, magnetohydrodynamics (MHD) calculations and simulations of microwave heating scenarios of the small modular Stellarator of Costa Rica 1 (SCR-1). Similarly, the design of a flexible bolometer and magnetic diagnostics (a set of Mirnov coils, Rogowski coils and two diamagnetic loops) are introduced. Furthermore, new MHD equilibrium calculations for the plasma of the SCR-1 device were performed using the VMEC code including the poloidal cross-section of the magnetic flux surfaces at different toroidal positions, profiles of the rotational transform, magnetic well, magnetic shear and total magnetic field norm. Charged particle orbits in vacuum magnetic field were computed by the magnetic field solver BS-SOLCTRA (Vargas et al. In 27th IAEA Fusion Energy Conference (FEC 2018), 2018. IAEA). A visualization framework was implemented using Paraview (Solano-Piedra et al. In 23rd IAEA Technical Meeting on the Research Using Small Fusion Devices (23rd TM RUSFD), 2017) and compared with magnetic mapping results (Coto-Vílchez et al. In 16th Latin American Workshop on Plasma Physics (LAWPP), 2017, pp. 43–46). Additionally, simulations of microwave heating scenarios were performed by the IPF-FDMC full-wave code. These simulations calculate the conversion of the ordinary waves to extraordinary waves and allow us to identify the location where the conversion takes place. Finally, the microwave heating scenarios for the $330^{\circ }$ toroidal position are presented. The microwave heating scenarios showed that the O–X–B mode conversion is around 12–14 %. It was possible to identify the spatial zone where the conversion takes place (upper hybrid frequency).
Technological and mathematical advances have provided opportunities to investigate new approaches for the holistic quantification of complex biological systems. One objective of these approaches, including the multi-inverse deterministic approach proposed in this paper, is to deepen the understanding of biological systems through the structural development of a useful, best-fitted inverse mechanistic model. The objective of the present work was to evaluate the capacity of a deterministic approach, that is, the multi-inverse approach (MIA), to yield meaningful quantitative nutritional information. To this end, a case study addressing the effect of diet composition on sheep weight was performed using data from a previous experiment on saccharina (a sugarcane byproduct), and an inverse deterministic model (named Paracoa) was developed. The MIA successfully revealed an increase in the final weight of sheep with an increase in the percentage of corn in the diet. Although the soluble fraction also increased with increasing corn percentage, the effective nonsoluble degradation increased fourfold, indicating that the increased weight gain resulted from the nonsoluble substrate. A profile likelihood analysis showed that the potential best-fitted model had identifiable parameters, and that the parameter relationships were affected by the type of data, number of parameters and model structure. It is necessary to apply the MIA to larger and/or more complex datasets to obtain a clearer understanding of its potential.
Social cognition is presently an important focus in rehabilitation of patients wish schizophrenic psychoses. Emotion recognition in one of its different components, the Training of Affect Recognition (TAR) is a therapy program specifically developed aiming at improving affect recognition.
Objectives
To test if the material of the TAR program in terms a series of facial affect cards is reliable for emotion recognition in a Spanish control population.
Methods
A sample of Spanish control subjects were shown the TAR's series of facial affect cards. It includes the following emotions: happiness, sadness, surprise, fear, angry and disgust, and the neutral facial affect. Reliability was assessed by means of the kappa coefficient. Kappa values higher than 0.4 were considered reliable, the following criterion was accepted: kappa values < 0.4, low reliability; 0.4 to 0.75, moderate reliability; > 0.76, strong reliability.
Results
The sample was formed by subjects from the general population with no previous history of psychiatric disorders (n = 20). The following kappa values were obtained: happiness, 0.8406 (CI 0.7744–0.9068), sadness, 0.6171 (CI 0.5377–0.6964), surprise, 0.6582 (CI 0.5859–0.7304), fear, 0.4509 (CI 0.3569–0.5448), angry, 0.6252 (CI 0.5464–0.7040), disgust, 0.7700 (CI 0.6943–0.8456), neutral, 0.5534 (CI 0.4663–0.6404).
Conclusions
In a preliminary study in a sample of 20 Spanish control subjects using the TAR's series of facial affect cards, the six basic emotions and the neutral facial affect were recognized with at least a moderate reliability. A strong reliability was obtained in happiness and disgust, and a moderate reliability in surprise, angry, sadness, neutral, fear.
NGC 7469 is a well-known type 1 AGN with a cirumnuclear star formation ring. It has previous detections of X-rays warm absorbers and an infrared biconical outflow. We analysed archival MUSE/VLT observations of this galaxy in order to look for an optical counterpart of these outflows. We report spatially resolved winds in the [O III] λ5007 emission line in two regimes: a high velocity regime possibly associated with the AGN and a slower one associated with the massive star formation of the ring. This slower regime is also detected with Hβ.
Like other Latin American countries, Colombia witnessed the rise of guerrilla movements in the 1960s and 1970s. However, unlike the rest of the region, armed opposition is still active to date and it is largely represented by the Revolutionary Armed Forces of Colombia (hereafter FARC from its acronym in Spanish). In addition to the guerillas the conflict features another illegal armed group since the early 1980s— the paramilitary forces. These rightwing militias were originally formed by local elites, landowners and drug lords to counteract guerrilla extortion and ransom tactics of the guerrillas. The Colombian conflict has been especially harmful for the civilian population. Both guerrillas and paramilitaries have specialized in victimizing civilians which includes the forced displacement of a large share of the population (Vargas, 2016). In fact, violence-driven internal migration has become the most dramatic social consequence of the conflict, affecting up to 90 percent of the country's municipalities. Many municipalities that receive internally displaced people (IDP) lack the capacity to handle the inflow of refugees. Moreover, 98 percent of displaced households live below the poverty line and face unemployment rates much higher than the rest of the population (Ibanez and Moya, 2010). IDP are among the most vulnerable populations in Colombia. For this reason, the United Nations classified this situation as “the biggest humanitarian crisis in Western Hemisphere” (UN, 2004).
According to Acción Social, Colombia's governmental agency in charge of social policy and humanitarian aid, by the end of 2009 approximately 3.5 million people had been forcibly displaced from their homes. This represents almost 9 percent of the nation's total population and roughly 8 percent of all IDP worldwide. According to statistics from the UN High Commissioner for Refugees (UNHCR, 2009), Colombia is one of the countries with the highest numbers of IDP worldwide, together with Iraq and Sudan.
Land disputes are the main driver of forced displacement: up to 4 million acres of land have been abandoned by the original owners. Colombia has today the most unequal land distribution of Latin America (Ibanez, 2009). The illegal expropriation of large amounts of acreage is also attributed to the need for arable land for the cultivation of coca, the main element used in the production of cocaine. Estimates show that Colombia exports approximately 70 percent of the world's supply (Mejia and Restrepo, 2010).
Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine whether exercise can lower depressive symptoms among women who began pregnancy at risk for depression using both a statistical significance and reliable and clinically significant change criteria.
Methods
This study is a secondary analysis of two randomized controlled trials that followed the same exercise protocol. Pregnant women were allocated to an exercise intervention group (IG) or control group (CG). All participants completed the Center for Epidemiological Depression (CES-D) scale at gestational week 9–16 and 36–38. Women with a baseline score ⩾16 were included. A clinically reliable cut-off was calculated as a 7-point change in scores from pre- to post-intervention.
Results
Thirty-six women in the IG and 25 women in the CG scored ⩾16 on the CES-D at baseline. At week 36–38 the IG had a statistically significant lower CES-D score (14.4 ± 8.6) than the CG (19.4 ± 11.1; p < 0.05). Twenty-two women in the IG (61%) had a clinically reliable decrease in their post-intervention score compared to eight women in the CG (32%; p < 0.05). Among the women who met the reliable change criteria, 18 (81%) in the IG and 7 (88%) in the CG had a score <16 post-intervention, with no difference between groups (p > 0.05).
Conclusions
A structured exercise program might be a useful treatment option for women at risk for prenatal depression.