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Introduction and Objectives: Cognitive impairment-dementia is an increasing health concern with a major economic and social impact. This study aims to examine how it is currently approached in primary care practices in the Autonomous Community of Galicia, Spain.
Methods: A working group was formed between two scientific societies, which developed a survey that was sent online to 2206 primary care doctors, subsequently analysing the responses received.
Results: A total of 124 primary care doctors (5.3%) responded to the survey, 69.4% of which were women, with a mean age of 54 years. Out of these doctors, 92 (80%) have been working for more than 10 years, 30 (24.2%) have never received any training on the topic of study and only 31 (25%) have received some training in the last 5 years. The initial complaint derives from close relatives (76.6%) and this complaint usually entails memory problems (59.7%). The screening test used by 77.4% of the professionals is the MMSE with a higher prevalence among younger doctors (p-value 0.04). In the case of suspected cognitive impairment, doctors perform a cognitive assessment scale (96%), order a blood test (83.9%) and perform functional assessment scales (77.4%). They do so on a scheduled basis (79%). In total, 42.7% recognise that they reach the diagnosis in moderate dementia stages, hindered as a result of care-based reasons (66.9%). Doctors have difficulties in detecting the pathology associated with cognitive impairment in 52.4% of cases. In dementia management, 66.1% have difficulties in providing caregiver support and 42.7% with pharmacological treatment. In cases of advanced dementia, the problem is the lack of support from social services (47.6%), hospital specialists (45.2%) and the difficulty of pharmacological treatment (43.5%).
Conclusions: Primary care doctors report that the main barriers in the care for cognitive impairment-dementia are: training, healthcare organization, social, management of specific dementia treatments and associated pathologies and coordination with hospital care.
Key words: Primary care, cognitive impairment, dementia, screening, survey, attitudes
Long-term care facilities, such as nursing homes and other assisted living facilities, have been hit particularly hard by the COVID-19. The overall pandemic created an enormous pressure on long-term care workers (LTCWs), making them particularly vulnerable to mental disorders. However, most of the existing evidence regarding the well-being of care professionals has predominantly focused on frontline healthcare workers.
Objectives
This study aimed to identify long-term psychological needs of LTCWs derived from the COVID-19 pandemic, as part of a project that is developing an intervention to reduce psychological distress in this population group.
Methods
We performed a qualitative study with a rapid research approach. Participants were recruited from long-term care facilities located in Catalonia, Spain. Between April and September 2022, we conducted semi-structured interviews inquiring about the most psychologically challenging stages of the pandemic, perceived emotions during those stages, main determinants of those emotions, and their emotional state at the time of the interview. We used a qualitative content analysis method with an inductive-deductive approach.
Results
Thirty LTCWs participated in the study. Mean age was 44 (SD=11,4), 87% were females and one third were from foreign nationalities. The period of the pandemic with highest mental health burden was the outbreak, with almost every worker having experienced some form of emotional distress. Emotional distress persisted over time in more than half of participants, with fatigue and nervousness being the main emotions expressed at the time of the interview. High workload, feeling that pandemic times are not over and poor working conditions that have remained since then, have been the most frequently expressed determinants of such emotions.
Conclusions
Long after the pandemic outbreak, emotional distress is still relevant. The persistent burden of psychological distress points to a need for institutions to take action to improve working conditions and promote employees’ wellbeing.
Assess effects on waist circumference from diet with or without cereal grains and with or without long-term physical exercise.
Background:
Elevated waist circumference is an indicator of increased abdominal fat storage and is accordingly associated with increased cardiovascular mortality. This is likely due to the association between lifestyle-induced changes in waist circumference and cardiovascular risk factors. Reductions in waist circumference may be facilitated by diet without cereal grains combined with long-term physical exercise.
Methods:
Two-year randomised controlled trial with factorial trial design in individuals at increased risk of cardiovascular disease with increased waist circumference. Participants were allocated diet based on current Swedish dietary guidelines with or without cereal grains (baseline diet information supported by monthly group sessions) and with or without physical exercise (pedometers and two initial months of weekly structured exercise followed by written prescription of physical activity) or control group. The primary outcome was the change in waist circumference.
Findings:
The greatest mean intervention group difference in the change in waist circumference among the 73 participants (47 women and 26 men aged 23–79 years) was at one year between participants allocated a diet without cereal grains and no exercise and participants allocated a diet with cereal grains and no exercise [M = −5.3 cm and −0.9 cm, respectively; mean difference = 4.4 cm, 4.0%, 95% CI (0.0%, 8.0%), P = 0.051, Cohen’s d = 0.75]. All group comparisons in the change in waist circumference were non-significant despite the greatest group difference being more than double that estimated in the pre-study power calculation. The non-significance was likely caused by too few participants and a greater than expected variability in the change in waist circumference. The greatest mean intervention group difference strengthens the possibility that dietary exclusion of cereal grains could be related to greater reduction in waist circumference.
Key tipping points of history are rarely found directly in the archaeological record, not least because an event's significance often lies in the perception of the participants. This article documents an early-ninth-century ritual fire-burning event at the Maya site of Ucanal in Guatemala and argues that it marked a public dismantling of an old regime. Rather than examine this event as part of a Classic period Maya collapse, the authors propose that it was a revolutionary pivot point around which the K'anwitznal polity reinvented itself, ushering in wider political transitions in the southern Maya Lowlands.
To investigate the impact of early vs. late palliative care (PC) on the frequency of admissions to acute hospital settings and the utilization of end-of-life (EoL) interventions in cancer decedents.
Methods
In this single-center, cross-sectional study, we examined the frequency of intensive care unit (ICU) and emergency department (ED) admissions among adult cancer decedents between 2018 and 2022 in a referral hospital in México. Additionally, we assessed EoL medical interventions, categorizing patients into 3 groups: those who received early PC (EPC), late PC (LPC), and those who did not receive PC (NPC).
Results
We analyzed data from 1762 patients, averaging 56 ± 16.3 years old, with a predominant representation of women (56.8%). PC was administered to 45.2% of patients, but EPC was limited to only 12.3%. The median time from the initiation of PC to death was 5 days (interquartile range: 2.0–31.5). Hematological malignancies were the most prevalent, affecting 21.5% of patients. EPC recipients demonstrated notable reductions in ICU and ED admissions, as well as diminished utilization of chemotherapy, radiotherapy (RT), antibiotics, blood transfusions, and surgery when compared to both LPC and NPC groups. EPC also exhibited fewer medical interventions in the last 14 days of life, except for RT.
Significance of results
The findings of this study indicate that a significant proportion of EoL cancer patients receive PC; however, few receive EPC, emphasizing the need to improve accessibility to these services. Moreover, the results underscore the importance of thoughtful deliberation regarding the application of EoL medical interventions in cancer patients.
Across three studies, we explored the link between an abstract mindset and subjective well-being (SWB) in participants with real and/or perceived financial scarcity. In Studies 1 and 2, samples presented real objective financial vulnerability: Adolescents from lower-middle income districts (Study 1; N = 256), and adults without higher education and with very low incomes (Study 2; N = 210). In Studies 1 and 2 participants completed a survey including measures of thinking style and SWB. In Studies 2 and 3 perception of financial difficulty and SWB were also measured. Study 3 (N = 161) used a sample of university students and employed an experimental design manipulating participants’ thinking style (i.e., concrete versus abstract mindset conditions); additionally, all participants were induced to perceive financial scarcity. Correlations revealed a significant and positive relationship between an abstract thinking style and SWB (Studies 1 and 2). Thus, these results showed that a relatively more abstract thinking style was associated with greater life satisfaction. In Studies 2 and 3 mediation analyses indicated that adults who presented a more abstract thinking style, perceived lower financial difficulties and then reported greater SWB. Overall, given that an abstract thinking style can be induced, these results offer a new intervention approach for improving the SWB of people living in situations of financial scarcity.
Transcutaneous spinal cord stimulation (TSCS) is gaining popularity as a noninvasive alternative to epidural stimulation. However, there is still much to learn about its effects and utility in assisting recovery of motor control. In this study, we applied TSCS to healthy subjects concurrently performing a functional training task to study its effects during a training intervention. We first carried out neurophysiological tests to characterize the H-reflex, H-reflex recovery, and posterior root muscle reflex thresholds, and then conducted balance tests, first without TSCS and then with TSCS. Balance tests included trunk perturbations in forward, backward, left, and right directions, and subjects’ balance was characterized by their response to force perturbations. A balance training task involved the subjects playing a catch-and-throw game in virtual reality (VR) while receiving trunk perturbations and TSCS. Balance tests with and without TSCS were conducted after the VR training to measure subjects’ post-training balance characteristics and then neurophysiological tests were carried out again. Statistical comparisons using t-tests between the balance and neurophysiological data collected before and after the VR training intervention found that the immediate effect of TSCS was to increase muscle activity during forward perturbations and to reduce balance performance in that direction. Muscle activity decreased after training and even more once TSCS was turned off. We thus observed an interaction of effects where TSCS increased muscle activity while the physical training decreased it.
An estimated 17.9 million people died from cardiovascular diseases (CVDs) in 2019, which is 32 percent of all global deaths and 85 percent were due to heart attack and stroke. Chest pain is one of the most common reasons for presenting to the emergency department (ED). It is increasingly recognized that artificial intelligence (AI) will have a significant impact on the practice of medicine in the near future and may help with diagnosis and risk stratification. We aim to estimate a diagnostic prediction of acute myocardial infarction by the development and validation of an AI model.
Methods
Data on 134 variables of 3,986 consecutive patients who presented to the ED with non-traumatic chest pain were included in the analysis. Using AI tools, a neural network model was developed to establish the risk of acute myocardial infarction (AMI) to achieve n=150 patients over 18 years of age attending the ED.
Results
The mean age was 65.5 (±13.7) years and 63.6 percent were male. Most (60.1%) patients were admitted to hospital, with only 20.3 percent diagnosed at hospital discharge with ischemic heart disease (IHD). All patients were followed up for two months, and 6.3 percent were readmitted to the ED, but none presented with an episode of IHD. In the data analysis of the entire sample we obtained a probability of diagnosing IHD by the SmartHeart model (S=93.1%, E=47.3%, PPV=31.0%, and NPV=96.4%). When we analyzed the sample of patients with no history of IHD (n=104), the diagnosis accuracy was as follows (S=100%, E=77.5%, PPV=42.8%, and NPV=100%).
Conclusions
Our AI model provides information to predict patients who are suffering from acute IHD. AI has been reported to outperform emergency physicians and current risk stratification tools to diagnose IHD, but has rarely been integrated into practice. This study highlights the diagnostic applicability and accuracy of this type of tool and that is why studies should be implemented to see its effectiveness in routine practice in EDs.
Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances.
Methods
We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis–Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups.
Results
FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio.
Conclusions
Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.
En este trabajo se discute un conjunto de indicios de poblamiento humano en diferentes locus de la Pampa Occidental: el sitio 1 de la localidad Tapera Moreira, El Carmel y Casa de Piedra. El poblamiento inicial de este territorio ha estado restringido a un solo dato cronológico correspondiente al Holoceno temprano, proveniente del sitio Casa de Piedra 1 (8620 ± 190 años aP) que no ha sido replicado en ese u otros sitios de la región. Por ello no ha sido incorporado en la agenda de la discusión sobre esta temática en publicaciones recientes. Sin embargo, en años posteriores a su publicación se han suscitado diversos hallazgos cuyos contextos señalan gran potencial informativo en relación con la ocupación humana inicial de paisajes sin historia previa. Se presentan indicadores de cultura material (puntas de tipo cola de pescado, litos discoidales y materias primas muy seleccionadas y con tratamiento térmico) recuperados en asociación en diferentes locus pampeanos, que se relacionan con las expectativas generadas para una etapa de ocupación inicial del paisaje. Se propone un modelo de exploración lenta y discontinua que utilizó vías de transitabilidad de distinto rango en el proceso de conocimiento y colonización de estos ambientes desérticos.
In this article, we offer a framework for understanding the role that racial group consciousness (RGC) plays in influencing Black Americans’ engagement in costly political action. Attempting to add clarity to decades of inconsistent and at times contradictory findings, we argue that the effect of RGC at inspiring political action among Black Americans is conditional on (1) the relevance of the political activity to achieving a well-recognized racial group outcome and (2) individual capacity to assume the cost of engaging in the activity. Analyzing data from the ANES and two behavioral experiments, we find that RGC exhibits a consistently strong relationship with engagement in low-cost political behavior, regardless of whether the behavior has some explicit group-relevant outcome. When engagement becomes more costly, however, Blacks high in RGC are only willing to assume these costs if the engagement has some clear potential for racial group benefit.
This Element challenges prevailing views of boredom as a modern phenomenon and as an experience occurring inside our minds. It discusses the changing perspectives on boredom within psychology, psychiatry and psychoanalysis on both sides of the Atlantic in the last 100 years. It also analyzes visual and textual material from France, Germany, Britain, Argentina and Spain, which illustrates the kinds of social situations, people and interactions that have been considered tedious or boring in the past five centuries. Examining the multidirectional ways in which words like ennuyeux, 'tedious', langweilig, aburrido and 'boring' have been transferred between different cultural contexts (to denote a range of interrelated feelings that include displeasure, unease and annoyance), it demonstrates how the terms, concepts and categories through which individuals have experienced their states of mind are not simply culture-bound. They have also travelled across geographical and linguistic barriers, through translation, imitation and adaptation. This title is also available as Open Access on Cambridge Core.
Mood Disorder (MD) affects more than 300 million people globally, and its etiology is unknown. In recently published data, MD has been correlated with inflammation and the immune system. Circulating monocytes have been proposed to play a role in the pathophysiology of depression.
Objectives
To determine if there is a specific activation profile of monocytes in patients with MD that differentiates them from healthy control (HC).
Methods
Study Design: Case-control study matched by sex and age. The study was approved by IRB and carried out in three hospitals in Argentina.Participants between 18 and 55 years old from both genders, were evaluated by psychiatrists using the International Psychiatry Interview (MINI) to diagnose Mood Disorder (MD), and the Hamilton Depression Rating Scale (HADRS) to define active disease (AD), non-active disease (NAD) or healthy control (HC). The three monocyte subtypes were directly stained and analyzed in a drop of 100 uL of blood sample based on our validated monocyte cocktail including CD11b, HLA-DR, CD86, CD14 and CD16 expression by flow cytometry. To define normality Kolmogorov-Smirnov test was employed. A parametric T-test with Welch´s correction was employed for normal distribution and a non-parametric Mann Whitney test was used when comparing populations that do not pass the normality test.
Results
The sample characteristics were shown in Table 1. Patients with AD (Hamilton >7) (n: 37), patients with NAD (Hamilton <7) (n: 38), and HC (n: 39) were recruited. The percentage of classical monocytes decreased in AD vs NAD (p=0.04), both AD, and NAD have significantly lower levels of classical monocytes than HC (****p<0.001) (Image 1). The percentage of intermediate monocytes is higher in AD vs NAD (p=0.05), both AD, and NAD have significantly higher levels of intermediate monocytes than HC (****p<0.001) (Image 2). The percentage of non-classical monocytes is higher in AD vs NAD (p=0.05), both AD, and NAD have significantly higher levels of non-classical monocytes than HC (****p<0.001) (Image 3).Table 1.
General characteristics of the sample
Active disease
Non-active disease
Healty control
n
37
38
39
Age (SD)
42.95 (11.78)
42 (12.02)
40.67 (11.42)
Women (%)
76.3
64.9
76.9
BD I
15.8
54.1
0.0
BD II
26.3
5.4
0.0
BD (non specified)
0.0
2.7
0.0
MDD
57.9
37.8
0.0
HAM-D 17 items mean (SD)
14.13 (4.89)
3.11 (2.35)
0.49 (0.85)
Image:
Image 2:
Image 3:
Conclusions
While comparing percentages of three different monocyte subsets, clear differences in their distribution among the control and patient groups were appreciated. After comparing the subset frequencies between active patients (AD) and patients who were in remission (NAD), significant differences among the subsets were found although without reaching values of the HC, indicating that even patients in remission show an activated monocyte profile.
This paper deals with the phenomenon of poverty-trap regimes in Mexico, that is, self-reinforcing mechanisms in which municipalities which start poor remain poor. We develop a coordination game of poverty traps driven by strategic interactions of economic agents: people choose to complete or not their education levels since it might be excessively costly and unprofitable. A one-shot game is constructed and then converted into a system of differential equations in which strategies that perform relatively better become more abundant in the population. Applying evolutionary games and symbolic-regimes dynamics (nonparametric and nonlinear techniques), we show that Mexican regions are in poverty-trap regimes (stable and dynamically evolving low-level equilibria) characterized by incomplete education and low income since initial conditions (education and income per capita) are such (very precarious) that poverty is the stable steady-state situation. We examine scenarios to show that to overcome the high-poverty regime by the year 2030, it is necessary to reduce incomplete education by 10% in the 5-year periods 2020–2025 and 2025–2030 and increase per-capita income by 10% in both periods.
Two species of Teiichispira Yochelson and Jones reported from the Early/Middle Ordovician marine deposits of the San Juan Formation in the Argentine Precordillera are described. The new species Teiichispira teresae n. sp. is a component of the Early/Middle Ordovician marine gastropod assemblage in the studied region; Teiichispira argentina (Kayser), previously known from the San Juan Formation, is described with a complete teleoconch and associated operculum. The opercula of both Teiichispira species are complete and preserved in life position associated with the shell of T. argentina. The unguiculate morphology of the operculum is here interpreted as a mechanism for increasing the shell weight and ensuring anchoring to the substrate in a more or less fixed mode of life for Teiichispira, and as protection. The new occurrence of Teiichispira provides new taxonomic data on early Paleozoic marine gastropods in Argentina and testifies to a wide paleobiogeographical distribution for the genus, restricted to tropical and subtropical regions during the Early/Middle Ordovician.
In order to enhance genetic potential of chickpea materials from the National University of Córdoba Breeding Programme and Germplasm collection (Argentina), a study for a comprehensive understanding of the amount and pattern of genetic variation within and between genotypes was carried out by applying a multivariate analysis form single simple repeats (SSR) and morphological data. Molecular data were also used to determine the discriminating power for genotype identification, and to find the optimal primer combination to ensure unambiguous identification. With the analysis of 15 SSR markers on 53 genotypes, a total of 58 alleles were detected with individual values ranging from one to nine alleles per locus. High values of discriminating power (Dj ⩾ 0.7, PIC ⩾ 0.7), and low values of confusion probability (Cj ⩽ 0.23) were obtained for at least four evaluated markers. The combination of TA113 + TA114 + H1B09 + TA106 primers was effective for discriminating the 53 chickpea genotypes with a cumulative confusion probability value (Ck) of 9.60 × 10−4. Except for some exceptions, individual chickpea genotypes within a cluster in the consensus tree were definitely more closely related with each other by the origin or pedigree. The results confirmed that both multivariate data analysis methods, ordination and clustering, were complementary. In most genotypes, discriminant principal component analysis classification was consistent with the original clusters defined by molecular data. Differences in results from molecular and morphological data indicate that they provide complementary and relevant information for establishing genetic relationships among chickpea materials and a better description and interpretation of the available variability in the germplasm collection.
Marine ecotourism has undergone worldwide expansion in recent years, leading to increased concern regarding the impact on the environment. Despite this, however, few studies into the potential effect of tourist boats on dolphin welfare, have been carried out. In order to evaluate the impact of these activities on the presence and foraging behaviour of the threatened marine tucuxis (Sotalia fluviatilis), we observed them: 1) prior to the arrival of a boat in the bay; 2) for the duration of a vessel's stay in the bay and 3) after the boat's departure: ie pre-exposure, exposure and post-exposure phases. Both the average number of dolphins and the foraging activity were significantly reduced while a vessel was in the bay. Marine tucuxis are exclusively coastal and show fidelity to the site where they choose to live which makes any environmental disturbance of particular importance. Moreover, our findings are further evidence of the need for motorboat activity to be regulated and monitored to protect marine tucuxis as well as other coastal and estuarine dolphins.
This paper illustrates the results of research carried out at the archaeological site of Puig Castellar de Biosca (Catalonia, Spain), located in the northeast of the Iberian Peninsula. This Republican military fortress, a castellum, is exceptional due both to its early chronology, which ranges between 180 and 120 BCE, and to the fact that it acted as a long-lasting military installation situated in a pacified area on the periphery of the Celtiberian conflict zone. Work at the site has uncovered a central building on the top of a hill, which due to its Italian features has been identified as the headquarters of the military fortress. If this interpretation is correct, this might be one of the first examples of a Republican military headquarters building documented to date. It could then be considered a predecessor of later praetoria and principia, which have been recorded in the Numantine camps and on the Roman western limes.