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In 1893 Clara Lindow sang the ballad Dreamtide to her own guitar accompaniment in the Cumbrian hamlet of Lowick. A writer for the local newspaper not only admired her 'marked skill and ability' but also considered the concert to be a sign of 'the onward march of light and learning in our time'. Amateurs like Miss Lindow were at the heart of a Victorian revival of guitar playing, especially for accompanying the voice, which has never been fully acknowledged and has often been denied. This book is a ground-breaking history of the guitar and its players during the era when the Victorians were making modern Britain. The abundant newspaper record of the period, much of which is now searchable with digital tools, reveals an increasingly buoyant guitar scene from the 1860s onwards. No part of Victorian life, from palace to pavement, remained untouched by the revival.
For the trust game, recent models of belief-dependent motivations make opposite predictions regarding the correlation between back transfers and second-order beliefs of the trustor: while reciprocity models predict a negative correlation, guilt-aversion models predict a positive one. This paper tests the hypothesis that the inconclusive results in the previous studies investigating the reaction of trustees to their beliefs are due to the fact that reciprocity and guilt aversion are behaviorally relevant for different subgroups and that their impact cancels out in the aggregate. We find little evidence in support of this hypothesis and conclude that type heterogeneity is unlikely to explain previous results.
The replication crisis across several disciplines raises challenges for behavioural sciences in general. In this report, we review the lessons for experimental economists of these developments. We present the new research methods and practices which are being proposed to improve the replicability of scientific studies. We discuss how these methods and practices can have a positive impact in experimental economics and the extent to which they should be encouraged.
Super-resolution of turbulence is a term used to describe the prediction of high-resolution snapshots of a flow from coarse-grained observations. This is typically accomplished with a deep neural network and training usually requires a dataset of high-resolution images. An approach is presented here in which robust super-resolution can be performed without access to high-resolution reference data, as might be expected in an experiment. The training procedure is similar to data assimilation, wherein the model learns to predict an initial condition that leads to accurate coarse-grained predictions at later times, while only being shown coarse-grained observations. Implementation of the approach requires the use of a fully differentiable flow solver in the training loop to allow for time-marching of predictions. A range of models are trained on data generated from forced, two-dimensional turbulence. The networks have reconstruction errors which are similar to those obtained with ‘standard’ super-resolution approaches using high-resolution data. Furthermore, the methods are comparable to the performance of standard data assimilation for state estimation on individual trajectories, outperforming these variational approaches at initial time and remaining robust when unrolled in time where performance of the standard data-assimilation algorithm improves.
Health technology assessment (HTA) agencies assess the value of innovative therapies and publish recommendations for practice. However, is publishing HTA products sufficient to generate value in the real world? The objectives of our work were to: (i) determine whether innovative therapies for lung cancer produce the expected results in the real-world setting; and (ii) assess whether recommendations are followed in real-world practice.
Methods
Clinical administrative data were used in this two-phase project. In the first phase, a descriptive portrait of the use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for treating lung cancer was produced. Their value was assessed by comparing overall survival of treated patients observed in the province of Québec to the published literature. The second phase focused on the initial evaluation of patients diagnosed with lung cancer and treated first by surgery. The delay between first evidence of cancer and surgery was assessed, and the utilization of 27 healthcare services was analyzed and assessed according to our recommendations (algorithms) for lung cancer management.
Results
From the date the first EGFR-TKI was listed, it took about five years before these drugs were fully integrated into clinical practice. The median overall survival of patients in Québec who used an EGFR-TKI (three indications) was similar to that in most published studies, supporting previous reimbursement decisions. The median delay between first evidence of cancer and surgery was longer than the 60-day consensus target. Utilization of most healthcare services was heterogeneous between regions. Bronchoscopy on its own seemed overused in many regions, whereas non-surgical approaches as a first method for invasive mediastinal evaluation should have been more systematically applied.
Conclusions
At a relatively low cost, real-world evidence can serve as a powerful tool to validate reimbursement decisions and measure the state of clinical practice. By sharing results with stakeholders, it will enable clinical teams to reflect upon their practice and implement local improvement strategies.
We aim to estimate school value-added dynamically in time. Our principal motivation for doing so is to establish school effectiveness persistence while taking into account the temporal dependence that typically exists in school performance from one year to the next. We propose two methods of incorporating temporal dependence in value-added models. In the first we model the random school effects that are commonly present in value-added models with an auto-regressive process. In the second approach, we incorporate dependence in value-added estimators by modeling the performance of one cohort based on the previous cohort’s performance. An identification analysis allows us to make explicit the meaning of the corresponding value-added indicators: based on these meanings, we show that each model is useful for monitoring specific aspects of school persistence. Furthermore, we carefully detail how value-added can be estimated over time. We show through simulations that ignoring temporal dependence when it exists results in diminished efficiency in value-added estimation while incorporating it results in improved estimation (even when temporal dependence is weak). Finally, we illustrate the methodology by considering two cohorts from Chile’s national standardized test in mathematics.
Tall evergreen trees with bright-green, uniformly presented, overlapping and relatively large scale-like leaves of slightly fleshy appearance, which resemble lizard scales above and are prominently figured with bright-white markings within hollowed scale centres beneath.
Tall, and always remarkably erect, eventually large, dioecious evergreen, long-lived, resiniferous trees. When young and often throughout life they have very strongly whorled and stout, more or less level to typically somewhat ascending branch systems, usually with upturning tips, with the lower branch whorls either retained or eventually shed to leave clean trunks which sometimes bear further foliar episodes of crown reiteration from middle to higher portions of the trunk. Tree crowns generally highly symmetric.
A small tree of yew-like appearance, but differing mainly in having a spike of pollen cones with small scale leaves positioned between whorls of sporophylls, and females with yew-like arils which are white, rather than red, at maturity.
Moderate to large in size, tall and usually long-lived evergreen trees, with multiple slender, widely spaced branch and branchlet systems bearing typically willow-like (salignoid) leaves, which are dorsiventrally flattened to form distinctive upper and lower surfaces, each with a raised midrib along the dorsal side. The whole forms, when mature, usually broad open crowns borne from smoothly thin-barked trunks.
Tall, long-lived forest trees with rough-barked trunks, mostly developing a broad-crowned habit with age, bearing massive boughs and widely spreading flattened branch systems, giving mature trees a particularly stately and majestic habit with age, especially when growing in open park-like landscapes. Distinguished from Picea by the presence of short shoots with clustered leaves, and female cones which are stiffly erect, never pendulous, throughout life to maturity.
Medium-sized to tall and slender, evergreen trees of rather pine-like initial appearance, of slender habit and with slender horizontally spreading branches, with leaves of more Pseudotsuga-like habit, and the foliage bright green and relatively short-lived.
Moderate to large-sized, fast-growing, evergreen trees, mostly with dense, narrow, tapering pyramidal crowns. Leaves are ultimately shed cleanly by basal abscission zones which leave smooth, nearly circular scars to their shoots. Unlike Picea, leaves remain persistent on their shoots when branches are dried. Female cones are erect and seed liberation is by dismemberment of cone scales from the central columella, allowing both seed and scales to fall individually in the wind.
Cupressoid evergreen trees, the fresh branchlets with foliage are mostly held in vertical planes. The leaves are collectively somewhat spanner-like in shape, each etched across one or both surfaces with conspicuous white detailed markings. The pellucid foliage and characteristic white markings particularly distinguishes Austrocedrus.
Tall, pyramidal and often massive evergreen trees, typically with straight trunks and often irregularly protruding main branch systems, distinguished from Abies by their more irregular foliar habit and pendulous female cones with exerted trifid bracts.
Monopodial evergreen, mostly tall, long-lived forest trees with pillar-like trunks and canopy-emergent crowns. The foliage is bright green, of two types with few intermediates mixed together on the same shoot or mostly of one type predominant on different shoots. Leaves are small, symmetric, triangular, basally adpressed, spreading scale-like to awl-shaped, or larger, non-scale-like and bilaterally flattened, obliquely spreading into two opposite comb-like pectinate rows forming frond-like branchlet sprays. Foliage develops a billowing appearance en-masse.