Bilayer lipid membranes (BLMs), especially self-assembled bilayer lipid membranes on solid supports (s-BLMs), have been used in the last three years as lipid bilayer-based biosensors. In this paper, we will describe as well as review briefly our work on s-BLMs and closely related systems including the preparation and characterization of s-BLMs, hydrogen peroxide-sensitive electrodes based on s-BLMs, alkaline-pretreated aluminum electrodes as pH sensors, immobilization of ferrocene on a s-BLM as anamperometric sensor of Fe(CN)63-/4- ions, cyclic voltanmmetry studies of s-BLMs modified with electron mediators, TCPBQ/TCOBQ modified s-BLMs for pH measurements, TCNQ-modified s-BLMs for glucose detection, and s-BLMs on interdigital electrodes prepared by microelectronic techniques.