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3 - Schizophrenia and schizophrenia-like disorders

Published online by Cambridge University Press:  06 August 2009

Andrew F. Clark
Affiliation:
Prestwich Hospital, Manchester, UK
Christopher Gillberg
Affiliation:
Göteborgs Universitet, Sweden
Richard Harrington
Affiliation:
University of Manchester
Hans-Christoph Steinhausen
Affiliation:
Universität Zürich
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Summary

Introduction

Approximately 20 per cent of people with a lifetime diagnosis of schizophrenia date the first onset of their psychotic symptoms to before the age of 20 years. One of the key tasks therefore, of the child and adolescent psychiatrist is early recognition and treatment of the disorder notwithstanding its rarity in their overall practice. A much larger number of young people, however, are referred to child and adolescent mental health services with the key question ‘might this young person be developing or suffering from the early stages of schizophrenia or some other psychotic disorder?’. The clinician must also therefore, possess expert knowledge of both its typical and atypical presentations and its differential diagnoses.

Other psychotic disorders presenting during adolescence (and more rarely during childhood) are those of acute or transient psychotic disorders not lasting long enough for a diagnosis of schizophrenia, schizoaffective disorders, delusional disorders, psychotic episodes occurring as part of an underlying affective disorder and psychotic disorders secondary to substance misuse or to general medical conditions.

In many instances the clinician will be able to arrive at a clear formulation and diagnostic understanding and to develop a specific treatment plan. In others, however, diagnostic uncertainty will remain despite a full and careful assessment, even one lasting over a period of weeks. In these cases it is important that the clinician is able to tolerate this uncertainty whilst continuing to take a problem-focused approach to the young person's difficulties.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2006

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References

American Academy of Child and Adolescent Psychiatry, Practice parameter for the assessment and treatment of children and adolescents with schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 40(7) (2001), Suppl. 4S–23S. Standards and evidence base for current good practice in the assessment and treatment of children and adolescents with schizophrenia.
C. Barrowclough & N. Tarrier, Families of schizophrenic patients: cognitive behavioural intervention. In A practical guide to family intervention strategies. Cheltenham: Stanley Thornes, 1997).
Clark, A. F. & Lewis, S. W., Practitioner review: treatment of schizophrenia in childhood and adolescence. Journal of Child Psychology and Psychiatry, 39 (1998), 1071–81. Practical overview of current treatment issues for young people with schizophrenia, albeit becoming dated in respect of advice regarding use of atypical antipsychotics.Google Scholar
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National Institute for Clinical Excellence, Technology Appraisal No. 43: Guidance on the use of newer (atypical) antipsychotic drugs for the treatment of schizophrenia (London: NICE, 2002). UK-based guidance derived from a systematic review of clinical and cost effectiveness of antipsychotic drugs in treatment of schizophrenia.
Pilling, S., Bebbington, P., Kuipers, E.et al., Psychological treatments in schizophrenia: 1. Meta-analysis of family intervention and cognitive behaviour therapy. Psychological Medicine, 32 (2002), 763–82. Concludes that both family interventions and CBT have proven efficacy and should be routinely offered as part of treatment programme.Google Scholar
Pilling, S., Bebbington, P., Kuipers, E.et al., Psychological treatments in schizophrenia: 2. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation. Psychological Medicine, 32 (2002), 783–91. Concludes that neither social skills training nor cognitive remediation have yet been shown as effective for routine clinical practice.Google Scholar
, H. Remschmidt, Schizophrenia in Children and Adolescents (Cambridge: Cambridge University Press, 2001). Comprehensive overview of all aspects of schizophrenia in children and adolescents.
, D. Taylor, , H. McConnell, , D. McConnell & , R. Kerwin, The Maudsley 2001 Prescribing Guidelines (London: Martin Dunitz, 2001). Regularly updated guidelines with useful algorithms. Specific section on psychosis but not to treatment of children and adolescents.
, T. Wykes, , N. Tarrier & , S. Lewis, Outcomes and Innovation in the Psychological Treatment of Schizophrenia (Chichester: Wiley, 1998). Overview of range of psychological interventions appropriate to treatment of schizophrenia in adults.

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