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Chapter 26 - Neurodevelopmental Consequences of Neonatal Hypoglycemia

from Section 4 - Specific Conditions Associated with Fetal and Neonatal Brain Injury

Published online by Cambridge University Press:  13 December 2017

David K. Stevenson
Affiliation:
Stanford University, California
William E. Benitz
Affiliation:
Stanford University, California
Philip Sunshine
Affiliation:
Stanford University, California
Susan R. Hintz
Affiliation:
Stanford University, California
Maurice L. Druzin
Affiliation:
Stanford University, California
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Print publication year: 2017

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References

Tamaki, M, Fujitani, Y, Hara, A, et al. The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 2013; 123(10): 4513–24.CrossRefGoogle ScholarPubMed
Thorsson, AV, Hintz, RL. Insulin receptors in the newborn: increase in receptor affinity and number. N Engl J Med 1977; 297(17): 908–12.Google Scholar
Chernausek, SD, Beach, DC, Banach, W, Sperling, MA. Characteristics of hepatic receptors for somatomedin-C/insulin-like growth factor I and insulin in the developing human. J Clin Endocrinol Metab 1987; 64(4): 737–43.Google Scholar
Harken, AH, Filler, RM, AvRuskin, TW, Crigler, JF Jr. The role of “total” pancreatectomy in the treatment of unremitting hypoglycemia of infancy. J Pediatr Surg 1971; 6(3): 284–9.Google Scholar
Menni, F, de Lonlay, P, Sevin, C, et al. Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia. Pediatrics 2001; 107(3): 476–9.Google Scholar
Meissner, T, Wendel, U, Burgard, P, et al. Long-term follow-up of 114 patients with congenital hyperinsulinism. Eur J Endocrinol 2003; 149(1):4351.CrossRefGoogle ScholarPubMed
Steinkrauss, L, Lipman, TH, Hendell, CD, et al. Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism. J Pediatr Nurs 2005; 20(2): 109–18.CrossRefGoogle ScholarPubMed
Avatapalle, HB, Banerjee, I, Shah, S, et al. Abnormal neurodevelopmental outcomes are common in children with transient congenital hyperinsulinism. Front Endocrinol (Lausanne) 2013; 4:60.Google Scholar
Lord, K, Radcliffe, J, Gallagher, PR, et al. High risk of diabetes and neurobehavioral deficits in individuals with surgically treated hyperinsulinism. J Clin Endocrinol Metab 2015; 100(11): 4133–9.Google Scholar
Hoe, FM, Thornton, PS, Wanner, LA, et al. Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. J Pediatr 2006; 148(2): 207–12.CrossRefGoogle ScholarPubMed
Hume, R, McGeechan, A, Burchell, A. Failure to detect preterm infants at risk of hypoglycemia before discharge. J Pediatr 1999; 134(4):499502.Google Scholar
Lucas, A, Morley, R, Cole, TJ. Adverse neurodevelopmental outcome of moderate neonatal hypoglycemia. BMJ 1988; 297(6659): 1304–8.Google Scholar
Cornblath, M, Schwartz, R. Outcome of neonatal hypoglycaemia: complete data are needed. BMJ 1999; 318(7177): 194–5.CrossRefGoogle ScholarPubMed
Tin, W, Brunskill, G, Kelly, T, Fritz, S. 15-year follow-up of recurrent “hypoglycemia” in preterm infants. Pediatrics 2012; 130(6): e1497–503.Google Scholar
Kerstjens, JM, Bocca-Tjeertes, IF, de Winter, AF, et al. Neonatal morbidities and developmental delay in moderately preterm-born children. Pediatrics 2012:130(2): e265–72.Google Scholar
McIntyre, S, Taitz, D, Keogh, J, et al. A systemic review of risk factors for cerebral palsy in children born at term in developed countries. Dev Med Child Neurol 2013; 55(6): 499508.Google Scholar
Tam, EW, Haeusslein, LA, Bonifacio, SL, et al. Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy. J Pediatr 2012; 161(1): 8893.Google Scholar
Kaiser, JR, Bai, S, Gibson, N, et al. Association between transient newborn hypoglycemia and fourth-grade achievement test proficiency: a population-based study. JAMA Pediatr 2015; 169(10): 913–21.Google Scholar
McKinlay, CJ, Harding, JE. Revisiting transitional hypoglycemia: only time will tell. JAMA Pediatr 2015; 169(10): 892–4.Google Scholar
Boluyt, N, van Kempen, A, Offringa, M. Neurodevelopment after neonatal hypoglycemia: a systemic review and design of an optimal future study. Pediatrics 2006; 117(6): 2231–43.CrossRefGoogle Scholar
Waisbren, SE, Landau, Y, Wilson, J, Vockley, J. Neuropsychological outcomes in fatty acid oxidation disorders: 85 cases detected by newborn screening. Dev Disabil Res Rev 2013; 17(3): 260–8.CrossRefGoogle ScholarPubMed
Signorini, SG, Decio, A, Fedeli, C, et al. Septo-optic dysplasia in childhood: the neurological, cognitive and neuro-ophthalmological perspective. Dev Med Child Neurol 2012; 54(11): 1018–24.Google Scholar
Stanley, CA, Rozance, PJ, Thornton, PS, et al. Re-evaluating “transitional neonatal hypoglycemia”: mechanism and implications for management. J Pediatr 2015; 166(6): 1520–5.CrossRefGoogle ScholarPubMed
Thornton, PS, Stanley, CA, De León, DD, et al. Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children. J Pediatr 2015; 167(2): 238–45.Google Scholar
Bier, DM, Leake, RD, Haymond, MW, et al. Measurement of “true” glucose production rates in infancy and childhood with 6,6-dideuteroglucose. Diabetes 1977; 26(11): 1016–23.Google Scholar
Kalhan, SC, D’Angelo, LJ, Savin, SM, Adam, PA. Glucose production in pregnant women at term gestation: sources of glucose for human fetus. J Clin Invest 1979; 63(3): 388–94.Google Scholar
Bougneres, PF, Lemmel, C, Ferré, P, Bier, DM. Ketone body transport in the human neonate and infant. J Clin Invest 1986; 77(1): 42–8.CrossRefGoogle ScholarPubMed
Boardman, JP, Hawdon, JM. Hypoglycemia and hypoxic-ischaemic encephalopathy. Dev Med Child Neurol 2015; 57(Suppl 3):2933.Google Scholar
Sperling, MA, DeLamater, PV, Phelps, D, et al. Spontaneous and amino acid-stimulated glucagon secretion in the immediate postnatal period: relation to glucose and insulin. J Clin Invest 1974; 53(4): 1159–66.CrossRefGoogle ScholarPubMed
Guemes, M, Rahman, SA, Hussain, K. What is a normal blood glucose? Arch Dis Child 2016; 101(6): 569–74.CrossRefGoogle ScholarPubMed
Dekelbab, BH, Sperling, MA. Recent advances in hyperinsulinemic hypoglycemia of infancy. Acta Paediatr 2006; 95(10): 1157–64.Google Scholar
McKinlay, CJ, Alsweiler, JM, Ansell, JM, et al. Neonatal glycemia and neurodevelopmental outcomes at 2 years. N Engl J Med 2015; 373(16): 1507–18.Google Scholar
Auer, RN. Hypoglycemic brain damage. Metab Brain Dis 2004; 19(3–4): 169–75.Google Scholar
Turner, CP, Blackburn, MR, Rivkees, SA. A1 adenosine receptors mediate hypoglycemia-induced neuronal injury. J Mol Endocrinol 2004; 32(1): 129–44.Google Scholar
Kim, M, Yu, ZX, Fredholm, BB, Rivkees, SA. Susceptibility of the developing brain to acute hypoglycemia involving A1 adenosine receptor activation. Am J Physiol Endocrinol Metab 2005; 289(4): E562–9.Google Scholar
Mujsce, DJ, Christensen, MA, Vannucci, RC. Regional cerebral blood flow and glucose utilization during hypoglycemia in newborn dogs. Am J Physiol 1989; 256(6 Pt 2): H1659–66.Google Scholar
Karaoğlu, P, Polat, AI, Yiş, U, Hiz, S. Parieto-occipital encephalomalacia in children: clinical and electrophysiological features of twenty-seven cases. J Pediatr Neurosci 2015; 10(2): 103–7.CrossRefGoogle ScholarPubMed
LaManna, JC, Harik, SI. Regional comparisons of brain glucose influx. Brain Res 1985; 326(2): 299305.Google Scholar
Sperling, MA, Menon, RK. Differential diagnosis and management of neonatal hypoglycemia. Pediatr Clin North Am 2004; 51(3): 703–23.CrossRefGoogle ScholarPubMed
Duvanel, CB, Fawer, CL, Cotting, J, et al. Long-term effects of neonatal hypoglycemia on brain growth and psychomotor development in small-for-gestational-age preterm infants. J Pediatr 1999; 134(4): 492–8.Google Scholar
Rozance, PJ. Update on neonatal hypoglycemia. Curr Opin Endocrinol Diabetes Obes 2014; 21(1):4550.Google Scholar
Ferrara, C, Patel, P, Becker, S, et al. Biomarkers of insulin for the diagnosis of hyperinsulinemic hypoglycemia in infants. J Pediatr 2016; 168: 212–9.Google Scholar
Kelly, A, Tang, R, Becker, S, Stanley, CA. Poor specificity of low growth hormone and cortisol levels during fasting hypoglycemia for the diagnoses of growth hormone deficiency and adrenal insufficiency. Pediatrics 2008; 122(3): e522–8.CrossRefGoogle ScholarPubMed
Cornblath, M, Parker, ML, Reisner, SH, et al. Secretion and metabolism of growth hormone in premature and full-term infants. J Clin Endocrinol Metab 1965; 25: 209–18.Google Scholar
Kaplan, SL, Grumbach, MM, Shepard, TH. The ontogenesis of human fetal hormones. I. Growth hormone and insulin. J Clin Invest 1972; 51(12): 3080–93.Google Scholar
Lanes, R, Nieto, C, Bruguera, C, et al. Growth hormone release in response to growth hormone-releasing hormone in term and preterm neonates. Biol Neonate 1989; 56(5): 252–6CrossRefGoogle ScholarPubMed
Secco, A, di lorgi, N, Napoli, F, et al. The glucagon test in the diagnosis of growth hormone deficiency in children with short stature younger than 6 years. J Clin Endocrinol Metab 2009; 94(11): 4251–7.Google Scholar
Finegold, DN, Stanely, CA, Baker, L. Glycemic response to glucagon during fasting hypoglycemia: an aid in the diagnosis of hyperinsulinism. J Pediatr 1980; 96(2): 257–9.Google Scholar
Rahman, SA, Nessa, A, Hussain, K. Molecular mechanisms of congenital hyperinsulinism. J Mol Endocrinol 2015; 54(2): R119–29.Google Scholar
Barkovich, AJ, Ali, FA, Rowley, HA, Bass, N. Imaging patterns of neonatal hypoglycemia. AJNR Am J Neuroradiol 1998; 19(3): 523–8.Google Scholar
Alkalay, AL, Flores-Sarnat, L, Sarnat, HB, et al. Brain imaging findings in neonatal hypoglycemia: case report and review of 23 cases. Clin Pediatr (Phila) 2005; 44(9): 783–90.Google Scholar
Alkalay, AL, Flores-Sarnat, L, Sarnat, HB, et al. Plasma glucose concentrations in profound neonatal hypoglycemia. Clin Pediatr (Phila) 2006:45(6): 550–8.Google Scholar
Wong, DS, Poskitt, KJ, Chau, V, et al. Brain injury patterns in hypoglycemia in neonatal encephalopathy. AJNR Am J Neuroradiol 2013; 34(7): 1456–61.Google Scholar
Burns, CM, Rutherford, MA, Boardman, JP, Cowan, FM. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia. Pediatrics 2008; 122(1): 6574.Google Scholar
Bozzola, M, Adamsbaum, C, Biscaldi, I, et al. Role of magnetic resonance imaging in the diagnosis and prognosis of growth hormone deficiency. Clin Endocrinol (Oxf) 1996; 45(1): 21–6.Google Scholar
Kornreich, L, Horev, G, Lazar, L, et al. MR findings in growth hormone deficiency: correlation with severity of hypopituitarism. AJNR Am J Neuroradiol 1998; 19(8): 1495–9.Google Scholar
Dutta, P, Bhansali, A, Singh, P, et al. Congenital hypopituitarism: clinico-radiological correlation. J Pediatr Endocrinol Metab 2009; 22(10): 921–8.Google Scholar
Saudubray, JM, Martin, D, de Lonlay, P, et al. Recognition and management of fatty acid oxidation defects: a series of 107 patients. J Inherit Metab Dis 1999; 22(4): 488502.Google Scholar
Shulman, DI, Palmert, MR, Kemp, SF, Lawson Wilkins Drug and Therapeutics Committee. Adrenal insufficiency: still a cause of morbidity and death in childhood. Pediatrics 2007; 119(2): e484–94.CrossRefGoogle Scholar
Grimberg, A, DiVall, SA, Polychronakos, C, et al.; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society. Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency. Horm Res Paediatr. 2016; 86(6): 361–97.Google Scholar
Tas, E, Mahmood, B, Garibaldi, L, Sperling, M. Liver injury may increase the risk of diazoxide toxicity: a case report. Eur J Pediatr 2015; 174(3): 403–6.Google Scholar
Sperling, MA, Menon, R. Hypoglycemia in the Newborn. In Stevenson, DK, Cohen, RS, Sunshine, P, eds., Neonatology: Clinical Practice and Procedures, 1st ed. New York: McGraw-Hill Education, 2015: 649–64.Google Scholar
Palladino, AA, Bennett, MJ, Stanley, CA. Hyperinsulinism in infancy and childhood: when an insulin level is not always enough. Clin Chem 2008; 54(2): 256–63.Google Scholar
Laje, P, Halaby, L, Adzick, NS, Stanley, CA. Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism. Pediatr Diabetes 2010; 11(2): 142–7.Google Scholar
Demirbilek, H, Shah, P, Arya, VB, et al. Long-term follow-up of children with congenital hyperinsulinism on octreotide therapy. J Clin Endocrinol Metab 2014; 99(10): 3660–7.Google Scholar
Senniappan, S, Alexandrescu, S, Tatevian, N, et al. Sirolimus therapy in infants with severe hyperinsulinemic hypoglycemia. N Engl J Med 2014; 370(12): 1131–7.Google Scholar
Gopal-Kothandapani, JS, Hussain, K. Congenital hyperinsulinism: role of fluorine-18 L-3,4 hydroxyphenylalanine positron emission tomography scanning. World J Radiol 2014; 6(6): 252–60.Google Scholar
Suchi, M, MacMullen, CM, Thornton, PS, et al. Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism. Mod Pathol 2006; 19(1): 122–9.Google Scholar
Adzick, NS, Thornton, PS, Stanley, CA, et al. A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy. J Pediatr Surg 2004; 39(3): 270–5.CrossRefGoogle Scholar
Laje, P, Stanley, CA, Palladino, AA, et al. Pancreatic head resection and roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism. J Pediatr Surg 2012:47(1): 130–5.Google Scholar

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