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Chapter 9 - Hemolytic Disease of the Fetus and Newborn

Maternal Antibody Mediated Hemolysis

from Section III - Erythrocyte Disorders

Published online by Cambridge University Press:  30 January 2021

By
Mary Elizabeth Ross ,
Stephen P. Emery ,
Pedro A. de Alarcón  and
Jon F. Watchko
Edited by
Pedro A. de Alarcón ,
Eric J. Werner ,
Robert D. Christensen  and
Martha C. Sola-Visner
Pedro A. de Alarcón
Affiliation:
University of Illinois College of Medicine
Eric J. Werner
Affiliation:
Children's Hospital of the King's Daughters
Robert D. Christensen
Affiliation:
University of Utah
Martha C. Sola-Visner
Affiliation:
Harvard University, Massachusetts
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Summary

Hemolytic disease of the fetus and newborn (HDFN) is the immune mediated destruction of fetal and neonatal red blood cells by maternal antibody. HDFN occurs when the fetal red blood cells express a paternally inherited antigen not present on maternal red blood cells. The spectrum of illness ranges from clinically insignificant to that of a critically ill, anemic, hydropic, and jaundiced infant at risk for bilirubin-induced brain damage (kernicterus).

Type
Chapter
Information
Neonatal Hematology
Pathogenesis, Diagnosis, and Management of Hematologic Problems
 , pp. 133 - 154
Publisher: Cambridge University Press
Print publication year: 2021

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