Christian transnational advocacy networks (TANs) are the largest and oldest, continually functioning global networks. They are the leading providers of humanitarian aid and development assistance to Christian communities facing repression in all the world’s worst violators of international religious freedom, except Saudi Arabia. How are these Christian TANs, including women of faith, responding to Christian persecution? Women are more religious than men; thus religious repression and persecution disproportionately impacts women, and women of faith are frequently the first networks to respond. Christian TANs work to strengthen persecuted communities to stay in their home communities, but they also help refugees who flee, causing some to charge they “aid persecution.” Most Christian TANs adhere to humanitarian aid neutrality, providing assistance to all and hiring all “based on need, not creed.” They explicitly prohibit proselytizing, out of religious principles, but also for practical reasons, to increase social cohesion. Some seek converts, and are skeptical about the possibilities for peace between Christians and non-Christians. Christian TANs engage in governmental advocacy. They have succeeded in the passage of genocide resolutions against IS, but have been less successful in advocacy for refugee aid and resettlement.