Skip to main content Accessibility help
×
Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-24T02:38:41.043Z Has data issue: false hasContentIssue false

B - Research in Fetal Medicine

Published online by Cambridge University Press:  04 August 2017

P. M. Shaughn O'Brien
Affiliation:
Keele University School of Medicine
Fiona Broughton Pipkin
Affiliation:
University of Nottingham
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Polkinghorne, J. Review of the Guidance on the Research Use of Fetuses and Fetal Material. London: HMSO; 1989.Google Scholar
Human Tissue Act. London: HMSO; 2004. Human Tissue Authority. www.legislation.gov.uk/2004?title=Human%20tissue%20actGoogle Scholar
Human Tissue Authority. Code of Practice 1 – Consent. Version 14.0; July 2014. www.hta.gov.ukGoogle Scholar
Human Tissue Authority. Code of Practice 5 – Disposal of Human Tissue. Version 14.0; July 2014. www.hta.gov.ukGoogle Scholar
Human Tissue Authority. Guidance on the disposal of pregnancy remains following pregnancy loss or termination. www.hta.gov.uk/search?search_api_views_fulltext=Guidance+on+disposal+of+pregnancy+remains&sort_by=search_api_relevance&sort_by=search_api_relevanceGoogle Scholar
Royal College of Obstetricians and Gynaecologists. The Care of Women Requesting Induced Abortion. Evidence-based Clinical Guideline Number 7. London: RCOG Press 2011. www.rcog.org.uk/globalassets/documents/guidelines/abortion-guideline_web_1.pdfGoogle Scholar
Human Tissue Authority. Code of Practice 9 – Research. Version 14.0; July 2014. www.hta.gov.ukGoogle Scholar
Medical Research Council. Human Tissue and Biological Samples for Use in Research: Operational and Ethical Guidelines. London: MRC; 2014.Google Scholar
Chervenak, F McCullough, L. Ethics of Fetal Therapy. In: Fisk, NM, JrMoise, KJ., editors Fetal Therapy: Invasive and Transplacental. Cambridge: Cambridge University Press; 1997, pp. 345–56.Google Scholar
GRIT Study Group. A randomised trial of timed delivery for the compromised preterm fetus: Short term outcomes and Bayesian interpretation. BJOG 2003;110(1):2732.CrossRefGoogle Scholar
Unterscheider, J, Daly, S, Geary, MP, et al. Optimizing the definition of intrauterine growth restriction: The multicenter prospective PORTO Study. Am J Obstet Gynecol 2013;208(4):e291296.Google Scholar
Lees, C, Marlow, N, Arabin, B, et al. Perinatal morbidity and mortality in early-onset fetal growth restriction: Cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE). Ultrasound Obstet Gynecol 2013; 42(4):400–8.CrossRefGoogle ScholarPubMed
Lees, CC, Marlow, N, van Wassenaer-Leemhuis, A, et al. For the TRUFFLE study group. 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): A randomised trial. Lancet 2015 Mar 4 [published online].Google Scholar
Malone, FD, Canick, JA, Ball, RH, et al. First- and Second-Trimester Evaluation of Risk (FASTER) Research Consortium. First-trimester or second-trimester screening, or both, for Down’s syndrome. N Engl J Med 2005;353(19):2001–11.Google Scholar
Wald, NJ, Rodeck, C, Hackshaw, AK, Walters, J, Chitty, L, Mackinson, AM. First and second trimester antenatal screening for Down’s syndrome: The results of the Serum, Urine and Ultrasound Screening Study (SURUSS). J Med Screen 2003;10(2):56104.Google Scholar
Annual Report 2011–2. National Perinatal Epidemiology Unit, Oxford: NPEU 2013.Google Scholar
Calzolari, E, Barisic, I, Loane, M, et al.. Epidemiology of multiple congenital anomalies in Europe: A EUROCAT population-based registry study. Birth Defects Research (Part A) 2014;100:270–6.Google Scholar
Nair, M, Workman, M, Fitzpatrick, K, Peirsegaele, P, Kurinczuk, JJ, Knight, M. UKOSS Annual Report 2014. Oxford: National Perinatal Epidemiology Unit (2014).Google Scholar
Knight, M, Kenyon, S, Brocklehurst, P, Neilson, J, Shakespeare, J, Kurinczuk, JJ (Eds.) On Behalf of MBRRACE- UK. Saving Lives, Improving Mothers’ Care – Lessons Learned to Inform Future Maternity Care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009–12. Oxford: National Perinatal Epidemiology Unit, University of Oxford; 2014.Google Scholar
Andersen, SL, Olsen, J, Wu, CS, Laurberg, P. Spontaneous abortion, stillbirth and hyperthyroidism: A Danish population-based study. Eur Thyroid J 2014;3(3):164–72.Google Scholar
Kilic, D, Pedersen, H, Kjaersgaard, MI, et al. Birth outcomes after prenatal exposure to antiepileptic drugs – a population-based study. Epilepsia 2014;55(11):1714–21.Google Scholar
O’Neill, SM, Agerbo, E, Kenny, LC, et al. Cesarean section and rate of subsequent stillbirth, miscarriage, and ectopic pregnancy: a Danish register-based cohort study. PLoS Med 2014;11(7):e1001670.Google Scholar
Boers, KE, Vijgen, SM, Bijlenga, D, et al. DIGITAT study group. Induction versus expectant monitoring for intrauterine growth restriction at term: Randomised equivalence trial. BMJ 2010;341:c7087.CrossRefGoogle Scholar
Goncalves, LF, Lee, W, Espinoza, J, Romero, R. Examination of the fetal heart by four-dimensional (4D) ultrasound with spatio-temporal image correlation (STIC). Ultrasound Obstet Gynecol 2006;27:3648.CrossRefGoogle ScholarPubMed
Mari, G, for the collaborative group for Doppler assessment of the blood velocity in anemic fetuses. Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. N Engl J Med 2000;342:914.Google Scholar
Villa, CR, Habli, M, Votava-Smith, JK, et al. Assessment of fetal cardiomyopathy in early-stage twin-twin transfusion syndrome: comparison between commonly reported cardiovascular assessment scores. Ultrasound Obstet Gynecol 2014 Jun;43(6):646–51.CrossRefGoogle ScholarPubMed
Khalek, N, Johnson, MP, Bebbington, MW. Fetoscopic laser therapy for twin-to-twin transfusion syndrome. Seminars in Pediatric Surgery 2013; 22:1823.CrossRefGoogle ScholarPubMed
Lewi, L, Deprest, J, Hecher, K. The vascular anastomoses in monochorionic twin pregnancies and their clinical consequences. Am J Obstet Gynecol 2013;208(1):1930.Google Scholar
Royston, P. Constructing time-specific reference ranges. Stat Med 1991;10:675–90.CrossRefGoogle ScholarPubMed
Alfirevic, Z1, Stampalija, T, Gyte, GM. Fetal and umbilical Doppler ultrasound in high-risk pregnancies. Cochrane Database Syst Rev 2010.Jan 20;(1):CD007529. doi:10.1002/14651858.CD007529.pub2.Google Scholar
Unterscheider, J, Daly, S, Geary, MP, et al. Predictable Progressive Doppler Deterioration in IUGR – Does it really exist? Am J Obstet Gynecol 2013;209(6):539 e1–7.Google Scholar
Baschat, AA, Cosmi, E, Bilardo, CM, et al. Predictors of neonatal outcome in early-onset placental dysfunction. Obstet Gynecol 2007;109:253–61.CrossRefGoogle ScholarPubMed
Schuit, E, Amer-Wahlin, I, Ojala, K, et al. Effectiveness of electronic fetal monitoring with additional ST analysis in vertex singleton pregnancies at>36 weeks of gestation: an individual participant data metaanalysis. Am J Obstet Gynecol 2013, Mar;208(3):187 e1187.e13.Google Scholar
Saade, G. Fetal ECG analysis of the ST segment as an adjunct to intrapartum fetal heart rate monitoring: A randomized clinical trial. Am J Obstet Gynecol 2015;212(1 Suppl):S2.Google Scholar
Fisk, NM, Bower, S. Fetal blood sampling in retreat. BMJ 1993;307:143–4.Google Scholar
Maron, JL, Bianchi, DW. Prenatal diagnosis using cell-free nucleic acids in maternal body fluids: A decade of progress. Am J Med Genet 2007;145(1):517.Google Scholar
Campagnoli, C, Roberts, IA, Kumar, S, Bennet, PR, Bellantuono, I, Fisk, NM. Identification of mesenchymal stem/progenitor cells in human first trimester fetal blood, liver and bone marrow. Blood 2001;98:2396–402.CrossRefGoogle ScholarPubMed
Paiva, P, Whitehead, C, Saglam, B, Palmer, K, Tong, S. Measurement of mRNA transcripts of very high placental expression in maternal blood as biomarkers of preeclampsia. J Clin Endocrinol Metab 2011;96(11):1807–15.Google Scholar
Berry, S. Romero, R, Gomez, R, Ghezzi, F, Mazor, M, Tolosa, JE. Risks and ethical issues of the use of diagnostic cordocentesis in the evaluation of fetuses with preterm labor. Am J Obstet Gynecol 1997;176(Suppl 1):S20.Google Scholar
Tabor, A, Philip, J, Madsen, M, Bang, J, Obel, EB, Norgaard-Pederson, B. Randomised controlled trial of genetic amniocentesis in 4606 low-risk women. Lancet 1986; 1: 1287–93.Google Scholar
Hillman, SC, McMullan, DJ, Williams, D, Maher, ER and Kilby, MD. Microarray comparative genomic hybridization in prenatal diagnosis: a review. Ultrasound Obstet Gynecol 2012; 40: 385–91.Google Scholar
RCOG. Termination of Pregnancy for Fetal Abnormality – Report of a Working Party. RCOG London May 2010.Google Scholar
Lilford, R, Thornton, J, Braunholtz, D. Clinical trials and rare diseases: A way out of a conundrum. BMJ 1995; 311: 1621–5.Google Scholar
Deprest, J, Jani, J, Lewi, L, Ochsenbein-Kolble, N, Cannie, M, Done, E, Roubliova, X, Van Mieghem, T, Debeer, A, Debuck, F, Sbragia, L, Toelen, J, Devlieger, R, Lewi, P, Van de Velde M. Fetoscopic surgery: Encouraged by clinical experience and boosted by instrument innovation. Semin Fetal Neonatal Med 2006; 11: 398412.Google Scholar
Adzick, NS, Thom, EA, Spong, CY, Brock, JW 3rd, Burrows, PK, Johnson, MP, Howell, LJ, Farrell, JA, Dabrowiak, ME, Sutton, LN, Gupta, N, Tulipan, NB, D’Alton, ME, Farmer, DL; MOMS Investigators. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 2011; 364 (11): 9931004.Google Scholar
Deprest, et al. Changing Perspectives on the Perinatal Management of Isolated Congenital Diaphragmatic Hernia in Europe. Clin Perinatal 2009; 36: 329–47.Google Scholar
Morris, RK, Malin, GL, Quinlan-Jones, E, Middleton, LJ, Hemming, K, Burke, D, Daniels, JP, Khan, KS, Deeks, J, Kilby, MD. Percutaneous vesicoamniotic shunting in Lower Urinary Tract Obstruction (PLUTO) Collaborative Group. Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet 2013;382 (9903):1496–506.Google Scholar
Dhillon, RK, Hillman, SC, Pounds, R, Morris, RK, Kilby, MD. Comparison of Solomon technique against selective laser ablation for Twin-Twin Transfusion Syndrome: a systematic review. Ultrasound Obstet Gynecol. 2015; 46(5): 526–33.Google Scholar
Moldenhauer, JS, Soni, S, Rintoul, NE, Spinner, SS, Khalek, N, Martinez-Poyer, J, Flake, AW, Hedrick, HL, Peranteau, WH, Rendon, N, Koh, J, Howell, LJ, Heuer, GG, Sutton, LN, Johnson, MP, Adzick, NS. Fetal Myelomeningocele Repair: The Post-MOMS Experience at the Children’s Hospital of Philadelphia. Fetal Diagn Ther 2015; 37 (3): 235–40.Google Scholar
Kilby, MD and Morris, RK. An overview of the literature on congenital lower urinary tract obstruction and introduction to the PLUTO trial: Percutaneous shunting in lower urinary tract obstruction. Austr New Zeal J Obstet Gynaecol 2009; 49: 610.Google Scholar
Senat, MV, Deprest, J, Boulvain, M, Paupe, A, Winer, N, Ville, Y. Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome. N Engl J Med 2004; 351(2): 136–44.Google Scholar
Roberts, D, Neilson, JP, Kilby, MD, Gates, S. Interventions for the treatment of twin-twin transfusion syndrome. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD002073. doi:10.1002/14651858.CD002073.pub3.Google Scholar
Slaghekke, F, Lopriore, E, Lewi, L, Middeldorp, JM, van Zwet, EW, Weingertner, AS, Klumper, FJ, DeKoninck, P, Devlieger, R, Kilby, MD, Rustico, MA, Deprest, J, Favre, R, Oepkes, D. Fetoscopic laser coagulation of the vascular equator versus selective coagulation for twin-to-twin transfusion syndrome: An open-label randomised controlled trial. Lancet 2014 Jun 21; 383 (9935): 2144–51.CrossRefGoogle ScholarPubMed
Maxwell, D, Allan, L, Tynan, MJ. Balloon dilation of the aortic valve in the fetus: A report of two cases. Br Heart J. 1991; 65: 256–8.Google Scholar
Freud, LR, McElhinney, DB, Marshall, AC, Marx, GR, Friedman, KG, del Nido, PJ, et al. Fetal aortic valvuloplasty for evolving hypoplastic left heart syndrome: postnatal outcomes of the first 100 patients. Circulation. Aug 19 2014;130 (8):638–45.Google Scholar
Carpenter, R, Strasburger, JF, Garson, A, Smith, RT, Deter, RL, Englehardt, H. Fetal ventricular pacing for hydrops secondary to complete atrioventricular block. J Am Coll Cardiol. 1986; 8:1434–6.Google Scholar
Kumar, S, Paramasivam, G, Zhang, E, et al. Perinatal- and procedure-related outcomes following radiofrequency ablation in monochorionic pregnancy. Am J Obstet Gynecol 2014; 210:454 e16.Google Scholar
Bajoria, R, Oteng-Ntim, E, Fisk, NM. Transfer and metabolism of thyrotropin releasing hormone across the perfused human term placenta. J Clin Endocrinol Metab 1996; 81:3476–82.Google Scholar
Denbow, ML, Welsh, AW, Taylor, MJ, Blomley, MJ, Cosgrove, DO, Fisk, NM. Twin fetuses: Intravascular microbubble US contrast administration: early experience. Radiology 2000; 214: 724–8.Google Scholar
Ganzevoort, W1, Alfirevic, Z, von Dadelszen, P, Kenny, L, Papageorghiou, A, van Wassenaer-Leemhuis, A, Gluud, C, Mol, BW, Baker, PN. STRIDER: Sildenafil Therapy In Dismal prognosis Early-onset intrauterine growth Restriction–a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis. Syst Rev. 2014 Mar 11;3:23.Google Scholar
Fisk, NM, Atun, R. Market failure and the poverty of new drugs in maternal health. PLoS Med 2008 Jan 22; 5 (1): 22.Google Scholar
Fisk, NM, Shennan, A H Litigation and prescribing drugs for unlicensed indications. Lancet 1993; 341: 1218.Google Scholar
Finning, KM, Martin, PG, Soothill, PW, Advent, ND. Prediction of fetal D status from maternal plasma: introduction of a new non-invasive fetal RHD genotyping service. Transfusion 2002; 42:1079–85.Google Scholar
Greene, MF and Phimister, EG. Screening for Trisomies in Circulating DNA. New Engl J Med 2014; 370(9): 874–5.Google Scholar
Bianchi, DW, Platt, LD, Goldberg, JD, Abuhamad, AZ, Sehnert, AJ, Rava, RP; MatErnal BLood IS Source to Accurately diagnose fetal aneuploidy (MELISSA) Study Group. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol. 2012 May; 119 (5): 890901.Google Scholar
Palomaki, GE, Kloza, EM, Lambert-Messerlian, GM, Haddow, JE, Neveux, LM, Ehrich, M, et al. DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study. Genet Med 2011; 13: 913–20.CrossRefGoogle ScholarPubMed
Norton, ME, Jacobsson, B, Swamy, GK, Laurent, LC, Ranzini, AC, Brar, H, Tomlinson, MW, Pereira, L, Spitz, JL, Hollemon, D, Cuckle, H, Musci, TJ, Wapner, RJ. Cell-free DNA Analysis for Noninvasive Examination of Trisomy. N Engl J Med 2015 Apr; 372(17): 1589–97.Google Scholar
Royal College of Obstetricians and Gynaecologists Scientific Impact Paper No. 16. Non-invasive prenatal testing for Chromosomal abnormality using maternal plasma DNA. RCOG: March 2014.Google Scholar
Dickens, BM. Ethical and legal aspects of non-invasive prenatal genetic diagnosis. Int J Gynaecol Obstet 2014; 124(2):181–4.Google Scholar
Swanson, AM, David, AL. Animal models of fetal growth restriction: Considerations for translational medicine. Placenta 2015; 36: 623630.Google Scholar
Carr, DJ., Wallace, JM., Aitken, RP., Milne, JS., Mehta, V, Martin, JF., Zachary, IC., Peebles, DM., and David, AL.. Uteroplacental Adenovirus Vascular Endothelial Growth Factor Gene Therapy Increases Fetal Growth Velocity in Growth-Restricted Sheep Pregnancies. Human Gene Therapy 2014; 25:375–84.Google Scholar
Estampador, AC and Franks, PW. Genetic and epigenetic catalysts in early-life programming of adult cardiometabolic disorders. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014:7 575–86.Google ScholarPubMed
Ilic, D and Polak, JM. Stem cells in regenerative medicine: introduction. British Medical Bulletin 2011; 98: 117–26.Google Scholar
O’Donoghue, K, Fisk, NM. Fetal stem cells. Best Pract Res Clin Obstet Gynaecol 2004; 18(6): 853–75.Google Scholar
Chan, J, O’Donoghue, K, Fisk, NM. Developmental Stem Cells. In: Progress in Obstetrics and Gynaecology, 17. J Studd (ed) pp 1530. London: Churchill Livingstone, 2006.Google Scholar
Götherström, C, Westgren, M, Shaw, S, Åström, E, Biswas, A, Byers, PH, Mattar, CNZ, Graham, GE, Taslimi, J, Ewald, U, Fisk, NM, Yeoh, AEJ, Lin, JL, Cheng, PJ, Choolani, M, K Le Blanc and JKY Chan. Pre- and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta: A Two-Center Experience. Stem Cells Translational Medicine 2014; 3: 110.Google Scholar
Buckley, SMK, Rahim, AA, Chan, JK, Dabid, AL, Peebles, DM, Coutelle, C and Waddington, SN. Recent advances in gene therapy. Therapeutic Delivery 2011; 2 (4):461–9.Google Scholar
Mehta, V, Nader, KA, Waddington D and David AL. Organ targeted prenatal gene therapy – how far are we? Prenat Diagn 2011; 31:720–34.Google Scholar
Coutelle, C, Themis, M, Waddington, SN, Buckley, SM, Gregory, LG, Nivsarkar, MS, David, AL, Peebles, D, Weisz, B, Rodeck, C. Gene therapy progress and prospects: fetal gene therapy-first proofs of concept-some adverse effects. Gene Ther 2005; 12: 1601–7.Google Scholar
MacKenzie, TC., David, AL., Flake, AW. and Almeida-Porada, G. Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy. Front. Pharmacol 2015; 6(15):12.Google Scholar
Hui, L and Bianchi, BW. Cell free fetal nucleic acids in amniotic fluid. Human Reproduction Update 2011; 17 (3):362–71.Google Scholar
Zwemer, LM and Bianchi, DW. The Amniotic Fluid Transcriptome as a Guide to Understanding Fetal Disease. Cold Spring Harb Perspect Med 2015; 5:a023101.Google Scholar
Vambergue, A and Fajardy, I. Consequences of gestational and pre-gestational diabetes on placental function and birth weight. World J Diabetes 2011; 2 (11):196203.Google Scholar
Desai, M, Jellyman, KJ and Ross, MG. Epigenomics, gestational programming and risk of metabolic syndrome. Int J Obes (Lond) 2015; 39(4): 633–41.Google Scholar
Bianchi, DW. Gross Lecture, Robert E.. Fetomaternal cell trafficking: A story that begins with prenatal diagnosis and may end with stem cell therapy. J Pediatr Surg 2007; 42(1):12–8.Google Scholar
O’Donoghue, K, Chan, J, de la Fuente, J, Kennea, N, Sandison, A, Anderson, JR, Roberts, IA, Fisk, NM. Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem cell trafficking in pregnancy. Lancet 2004; 364:179–82.Google Scholar
Lee, ESM, Bou-Gharios, G, Seppenan, E, Khosrotehrani, K and Fisk, NM. Fetal stem cell microchimerism: natural born healers or killers. Mol Hum Reprod, 2010; 16(11):869–78.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×