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Case 27 - Frontotemporal lobar dementia vs. solvent intoxication: A piece that does not fit the puzzle

Published online by Cambridge University Press:  16 May 2011

Serge Gauthier
Affiliation:
McGill University, Montréal
Pedro Rosa-Neto
Affiliation:
McGill University, Montréal
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Summary

This chapter talks about a 43-year-old male who was referred to a Memory Clinic by a psychiatrist to evaluate the possibility of Frontotemporal Lobar Dementia. Neuropsychological evaluation revealed a general cognitive functioning within normal limits, but weaknesses in some executive functions such as abstraction, attention/concentration, and working memory. The patient was taken out of his job environment. On the follow-up visit 11 months later, he felt improved significantly, but still complained of lack of energy and attention difficulties. When he tried returning to his previous professional duties doing mechanics and paint, he experienced readily mild acute intoxication symptoms. This is probably caused by hypersensitivity to chemicals associated with chronic solvent intoxication. Solvents are widely used in many industrial processes in our society. Since these agents are used to dissolve fatty substances, they easily penetrate cell membranes and they cross the blood-brain barrier.
Type
Chapter
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Case Studies in Dementia
Common and Uncommon Presentations
, pp. 201 - 207
Publisher: Cambridge University Press
Print publication year: 2011

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