This year is the 100th anniversary of the Nobel Prizes. On 10 December 1901, Röntgen received the first prize. Since then, some 700 Nobel Laureates have received the same honour. No prize in the world, at least no prize for science, has reached the same level of glory. How did it come to be so?

We are beginning to understand how the brain is organized and works, how it evolved in the remote past and how it continually forms during the embryonic development of individual organisms. The study of the brain and its activity has recently advanced at an accelerating pace thanks to the convergence of a number of research strategies. At least three research lines occupy a particular position among these strategies: genetics and the molecular biology of neural cells and the central nervous system; cognitive science; and brain imaging. If the brain is the subject of biological studies at the cellular, intercellular and circuitry levels, the approach to the study of mind should be more subtle. Nonetheless, science has progressed a long way in this direction. Some recent advances in this field are briefly reviewed here, with particular emphasis on brain evolution and development, the role of sensory organs, coding and the processing of sensorial information, memory, rationality, meaning and consciousness.

One of the discernible trends in the historiography of recent decades – especially in that which concerns the early modern centuries – has been the emergence of a literature that describes itself as Atlantic History. This paper seeks to identify positive and negative reasons why the once-popular history of exploration and discovery has given way to this new subject, it identifies some fresh meanings that may be drawn from some well-known sources when they are reappraised in an Atlantic context, and it suggests some possibly fruitful lines of enquiry that would lead to a better understanding of how an Atlantic world was fashioned and functioned during the sixteenth, seventeenth and eighteenth centuries. Finally, the paper draws a distinction between Atlantic history and Global history and suggests that the latter is a subject that belongs more properly to the nineteenth and subsequent centuries.

The definition of the term culture has become so vague as to be almost synonymous with human life; as an analytic term it has become nearly valueless. Of course, it can be used as a description of artistic activity, but this also becomes dubious when applied to popular mass culture. Culture often carries a sense of superior ethical values, but this too declines into confusion when multiculturism is opposed to culture as a whole.

However valuable as a term defining – by a shared language – a grouping of nations, ‘la Francophonie’ proves imprecise and divisive on closer analysis. In the field of literature, ‘Francophone’, despite its etymology (and the consequent absurdity of the phrase ‘Francophone literature’), has paradoxically come to exclude white writers from metropolitan France. At a time when the population of France is becoming increasingly multi-ethnic, any exclusion tainted with racism is particularly inappropriate. The centralizing mentality of France, politically motivated in the seventeenth century and entrenched over the years, is at odds with the ambition of universality except in terms of an assumed superiority through conquest or paternalism. The ‘mission civilisatrice’ has become the more insinuating ‘présence française’. For the literary scholar alert both to postcolonial discourses and to the heretofore marginalized texts of French literature dealing with blacks as well as to the dynamic contribution by black writers to literature in French, a new term is proposed: ‘la Francographie’. To replace the binary polarisation of French and Francophone, which fosters oppositional stances, comes a new model appropriate for our computer age: the net.

The Dead Sea area is unique in the sense that it is a natural laboratory in which key topics in several scientific disciplines can be studied in situ. Processes that take place during continental break-up, geochemistry and dynamics of the hypersaline Dead Sea water, paleoclimate and paleoseismic records in sediments and the survival mechanisms of halophilic micro-organisms are among the topics being studied there. Active tectonic processes control all aspects of the Dead Sea and have created an environment that has also influenced the course of human history.

In the 20th century, European countries had marked declines in mortality rates, initially at younger ages, and subsequently at older ages. This resulted in ‘rectangularization’ of the survival curve: large proportions of the population surviving to older ages, at which point mortality rates increase sharply. The extent to which this will be accompanied by increases in the proportions of older people suffering morbidity has been debated. There are marked differences in life expectancy at older ages among European countries. France, Italy, Spain, and Sweden have better than average life expectancy at age 65. Denmark, Germany, the UK and the Netherlands have lower. Within countries, there are marked socio-economic differences in morbidity and mortality at older ages. The impact of illness is also likely to differ according to an individual's social circumstances. It is essential to have longitudinal studies examining the determinants and impact of health and well-being in ageing populations. Ideally, these should be carried out in a way that facilitates international comparisons

An individual's personal sense of well-being (SWB) is an indicator of psychological adjustment and successful ageing. Health and functional capacity are viewed as important sources of life quality in old age but very little is known about their effects on SWB over time. Can older individuals maintain SWB despite declining health? Longitudinal data from the Berlin Aging Study, a locally representative sample of men and women aged 70 to 100+, indicate that cumulative health-related chronic life strains that characterize the Fourth Age set a constraint on the potential of the older individual to experience the positive side of life.

Studies of self-reported health on large cohorts in Sweden indicate that men and women in lower social classes in this country report considerably worse health than men and women in the upper classes. This is in line with many other research findings in many countries. What is interesting in Swedish data, however, is that self-reported health improved during the ten-year period after retirement. This was particularly pronounced during the years of financial crisis during the 1990s. Low decision latitude at work seems to account for part of the poor health in the lower social classes. An important task in future research will be to tie the epidemiological findings on ageing to endocrine factors strongly correlated with ageing, such as female and male sex hormones as well as their precursor, DHEA.

This paper highlights the role of chronic psychosocial stress in accelerated ageing and age-associated degenerative diseases, referring to the free radical theory of ageing. Chronic work stress in midlife provides an illustrative case to explore these associations, with an emphasis on cardiovascular disease and its subclinical precursors. It is argued that lack of control at work and the experience of an imbalance between efforts spent and rewards received at work trigger continued stress reactions with adverse long term effects on health. These conditions impair the working person's successful self-regulation in a core social role in adult life – the work role. Self-efficacy and self-esteem, two important psychological components of well-being and health, are compromised if personal control and social reward are lacking. Selected empirical results derived from epidemiological and experimental investigations are reported to illustrate this argument. In particular, otherwise healthy middle-aged employees suffering from stress at work are twice as likely to report a new cardiovascular disease in a five year period compared with their less stressed colleagues. In another study, an increase in average ambulatory systolic blood pressure and heart rate is observed in a group of workers characterized by an imbalance between effort and reward at work. The implications of this research for improved quality of life and healthy ageing in early old age concern the provision of adequate social roles, which offer opportunities for experiencing continued personal control and social reward. At the socio-political level, new forms of social productivity in economic and non-monetarized sectors need to be developed.

Retirement behaviour has been the focus of attention of much microeconomic research in recent years. At the same time, most industrialized countries are struggling with reforming their retirement systems to counteract adverse demographic shocks. Early retirement is an important aspect both in explaining retirement behaviour and in forecasting the future of welfare systems. In particular, early retirement is related to an important policy puzzle: it may be optimal to increase the legal retirement age, however we do not know enough of the behavioural response of workers to policy changes and whether these would be effective measures to counteract future fiscal imbalances. Social security systems (and many private pension plans) in Europe have encouraged early exits. This paper reviews the empirical literature on early retirement, with particular reference to OECD countries. The basic message emerging from our work is that much could be learnt by having better quality data, in particular micro-level data that could be used to estimate behavioural responses having under control the many factors affecting retirement decisions, including institutional factors and allowing for full cross country comparability.