During the late nineteenth century, contests over prohibition gripped hundreds of American towns and cities, nowhere with greater consequences than in the post-Reconstruction South. This article examines those effects in Greenville, South Carolina, a small marketing and manufacturing center in the white-majority upcountry. During the 1880s, prohibition split white Democrats who had “redeemed” Greenville's town government just a few years before and led to a surge in voter registration and participation among African Americans. The liquor question's repercussions for politics in the Gilded Age South have been largely neglected, both by social historians of prohibition and by political historians, who have failed to see it as one of the issues that roiled the region's politics between Reconstruction and the Populist rebellion. This article also emphasizes the overlooked importance of municipal elections and governance—even in so small a place as Greenville—as an arena for African Americans’ political activity. Greenville's black voters used their influence during the 1880s to achieve modest but tangible gains in education and municipal services and to erect at least a partial bulwark against the tide of white supremacy. These developments were part of a region-wide revival in African Americans’ municipal power, which Southern Democrats were careful to target in their disfranchising campaigns as the century drew to close.